Fmoc-Pro-OH | 1175902-42-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-Pro-OH
• 英文别名: 9H-fluoren-9-ylmethyl (2S)-2-acetylpyrrolidine-1-carboxylate
• CAS: 1175902-42-7
• 化学式: C₂₁H₂₁NO₃
• 分子量: 335.403
• InChiKey: WOBPMDDAYOEQGQ-FQEVSTJZSA-N

物化性质

• 沸点：
  504.4±43.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Fmoc-L-丙氨酸 、 N-芴甲氧羰基-O-beta-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-alpha-D-吡喃半乳糖基)-L-苏氨酸 、 ¹⁵N-ammonium chloride 、 Fmoc-Pro-OH 在 哌啶 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 、 N-甲基吡咯烷酮 为溶剂， 反应 0.29h， 生成
  参考文献：
  名称：

  Antifreeze glycopeptide analogues: microwave-enhanced synthesis and functional studies

  摘要：

  Antifreeze glycoproteins enable life at temperatures below the freezing point of physiological solutions. They usually consist of the repetitive tripeptide unit (-Ala-Ala-Thr-) with the disaccharide alpha-D-galactosyl(1-3)-beta-N-acetyl-D-galactosamine attached to each hydroxyl group of threonine. Monoglycosylated analogues have been synthesized from the corresponding monoglycosylated threonine building block by microwave-assisted solid phase peptide synthesis. This method allows the preparation of analogues containing sequence variations which are not accessible by other synthetic methods. As antifreeze glycoproteins consist of numerous isoforms they are difficult to obtain in pure form from natural sources. The synthetic peptides have been structurally analyzed by CD and NMR spectroscopy in proton exchange experiments revealing a structure as flexible as reported for the native peptides. Microphysical recrystallization tests show an ice structuring influence and ice growth inhibition depending on the concentration, chain length and sequence of the peptides.

  DOI：

  10.1007/s00726-008-0229-0

文献信息

• Bead diffusion assay for discovering antimicrobial cyclic peptides
  作者：Viviana S. Fluxà、Noélie Maillard、Malcolm G. P. Page、Jean-Louis Reymond

  DOI：10.1039/c0cc04670a

  日期：——

  A combinatorial library of 15,536 cyclic decapeptide analogues of tyrocidine A and gramicidin S was prepared on photocleavable TentaGel beads. The beads were photolyzed without solvent, and spread onto an agar plate inoculated with bacterial lawn. Clear zones were formed around beads carrying antimicrobially active peptides such as E18 c(kVOrnLfThiYOrnLq), which inhibited growth of B. subtilis and

  在光可裂解的TentaGel珠上制备了酪氨酸A和短杆菌肽S的15,536个环状十肽类似物的组合文库。将珠子在无溶剂的情况下光解，并铺在接种有细菌性草坪的琼脂平板上。在带有抗微生物活性肽（例如E18 c（kVOrnLfThiYOrnLq））的珠子周围形成了清晰的区域，该肽可抑制枯草芽孢杆菌和某些MRSA菌株的生长。
• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。