2-[(4-Methoxyphenyl)sulfanyl]benzamide | 89114-62-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[(4-Methoxyphenyl)sulfanyl]benzamide
• 英文别名: 2-(4-methoxyphenyl)sulfanylbenzamide
• CAS: 89114-62-5
• 化学式: C₁₄H₁₃NO₂S
• 分子量: 259.329
• InChiKey: BZYBGTXJKCGFRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[(4-Methoxyphenyl)sulfanyl]benzamide 在 lithium aluminium tetrahydride 、 吡啶盐酸盐 作用下， 以 乙醚 为溶剂， 反应 6.5h， 生成 4-[2-(Aminomethyl)phenyl]sulfanylphenol
  参考文献：
  名称：

  Jilek, Jiri; Sindelar, Karel; Pomykacek, Josef, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 12, p. 3294 - 3338

  摘要：

  DOI：
• 作为产物：
  描述：

  2-((4-methoxyphenyl)thio)benzoic acid 在 吡啶 、 氯化亚砜 作用下， 以 甲醇 、 苯 为溶剂， 反应 10.5h， 生成 2-[(4-Methoxyphenyl)sulfanyl]benzamide
  参考文献：
  名称：

  异羟肟酸的光化学

  摘要：

  已经研究了异羟肟酸的光化学反应。根据在光化学条件下用DCA进行的氧化，推测RCONH自由基的中间体。

  DOI：

  10.1016/s0040-4020(01)87717-6

文献信息

• Photochemistry of hydroxamic acids
  作者：B.D. Hosangadi、P.N. Chhaya、M.M. Nimbalkar、N.R. Patel

  DOI：10.1016/s0040-4020(01)87717-6

  日期：1987.1

  Photochemical reactions of hydroxamic acids have been studied. The intermediacy of a RCONH radical is postulated, based on oxidations achieved with DCA under photochemical conditions.

  已经研究了异羟肟酸的光化学反应。根据在光化学条件下用DCA进行的氧化，推测RCONH自由基的中间体。
• Synthesis of Diaryl Ethers, Diaryl Thioethers, and Diarylamines Mediated by Potassium Fluoride−Alumina and 18-Crown-6:  Expansion of Scope and Utility¹
  作者：J. Scott Sawyer、Elisabeth A. Schmittling、Jayne A. Palkowitz、William J. Smith

  DOI：10.1021/jo980800g

  日期：1998.9.1

  An efficient alternative to the Ullmann ether synthesis of diaryl ethers, diaryl thioethers, and diarylamines involving the SNAr addition of a phenol, thiophenol, or aniline to an appropriate aryl halide, mediated by potassium-fluoride alumina and 18-crown-6 in acetonitrile or DMSO, is described. Expansion of the reaction conditions to include DMSO as solvent has resulted in a far greater range of substitution patterns permitted on the electrophile. For example, it was found that electronically unfavorable S-chlorobenzonitrile could be condensed with 3-methoxyphenol to form the corresponding diaryl ether in 66% yield, a combination not normally amenable to Ullmann coupling. Electron-withdrawing groups present on the electrophile may be as diverse as nitro, cyano, formyl, acetyl, ester, amide, and even aryl. The method features a simple reaction procedure that provides products in generally good to excellent purified yields.
• Photochemical reactions of benzohydroxamic acids
  作者：Pradeep Chhaya、Manmohan Nimbalkar、Bhaskar Hosangadi

  DOI：10.1016/s0040-4039(00)94138-8

  日期：1983.1
• HOSANGADI, B. D.;CHHAYA, P. N.;NIMBALKAR, M. M.;PATEL, N. R., TETRAHEDRON, 43,(1987) N 22, 5375-5380
  作者：HOSANGADI, B. D.、CHHAYA, P. N.、NIMBALKAR, M. M.、PATEL, N. R.

  DOI：——

  日期：——
• SYSTEM AND METHOD FOR HOMOGENOUS GPCR PHOSPHORYLATION AND IDENTIFICATION OF BETA-2 ADRENERGIC RECEPTOR POSITIVE ALLOSTERIC MODULATORS
  申请人：Duke University

  公开号：EP3787637A1

  公开（公告）日：2021-03-10