N-4'-(3",5"-dibromophenoxy)butylphthalimide | 1048041-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-4'-(3",5"-dibromophenoxy)butylphthalimide
• 英文别名: 1-(4'-phthalimidobutoxy)3,5-dibromobenzene；2-[4-(3,5-dibromophenoxy)butyl]isoindole-1,3-dione
• CAS: 1048041-76-4
• 化学式: C₁₈H₁₅Br₂NO₃
• 分子量: 453.13
• InChiKey: QRUPFRDIUNLAQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-4'-(3",5"-dibromophenoxy)butylphthalimide 在 盐酸 、 一水合肼 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 生成 Tert-butyl 4-(3,5-dibromophenoxy)butylcarbamate
  参考文献：
  名称：

  Novel reagents for directed biomarker signal amplification

  摘要：

  本文描述了涉及中性共轭聚合物的方法、组合物和制造物品，包括合成具有连接物的中性共轭水溶性聚合物的方法，连接物沿聚合物主链结构和末端封端单元。这种聚合物可用于制备新型光电子器件，并在高效生物传感器的开发中发挥作用。该发明进一步涉及这些聚合物在测定方法中的应用。

  公开号：

  US20110256549A1
• 作为产物：
  描述：

  N-(4-溴丁基)邻苯二甲酰亚胺 、 3,5-二溴苯酚 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以87%的产率得到N-4'-(3",5"-dibromophenoxy)butylphthalimide
  参考文献：
  名称：

  FLUORESCENT METHODS AND MATERIALS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION

  摘要：

  公开号：

  EP2164988B1

文献信息

• Fluorescent Methods and Materials for Directed Biomarker Signal Amplification
  申请人：Gaylord Brent S.

  公开号：US20080293164A1

  公开（公告）日：2008-11-27

  Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

  提供了包括多色团和/或多色团复合物的方法和组合物，用于识别目标生物分子。例如，传感器生物分子（如抗体）可以与多色团共价连接。此外，信号色团可以与多色团共价连接。排列是这样的，即在多色团激发时，信号色团能够从多色团接收能量。由于传感器生物分子能够与目标生物分子相互作用，因此多色团和/或多色团复合物可以为目标生物分子提供增强的检测信号。
• Fluorescent methods and materials for directed biomarker signal amplification
  申请人：Sirigen, Inc.

  公开号：US08158444B2

  公开（公告）日：2012-04-17

  Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

  本发明提供了一种包括多色团和/或多色团复合物的方法和组合物，用于识别目标生物分子。例如，可以共价连接传感器生物分子（如抗体）到多色团上。此外，信号色团可以共价连接到多色团上。排列使信号色团能够在多色团被激发时从多色团接收能量。由于传感器生物分子能够与目标生物分子相互作用，因此多色团和/或多色团复合物可以为目标生物分子提供增强的检测信号。
• SIGNAL AMPLIFIED BIOLOGICAL DETECTION WITH CONJUGATED POLYMERS
  申请人：Liu Bin

  公开号：US20120252986A1

  公开（公告）日：2012-10-04

  The devices and method are provided for detecting labeled and label-free analytes, such as nucleic acids and proteins, employing conjugated cationic, anionic and neutral polymers. The analytes can be immobilized on a solid support material. The solid support material can be disposed in the pre-fabricated patterns on a substrate. The chemical structures of the polymers employed by the various embodiments of the present invention are described herein.

  本发明提供了用于检测标记和非标记分析物（如核酸和蛋白质）的装置和方法，采用共轭阳离子、阴离子和中性聚合物。分析物可以固定在固体支撑材料上。固体支撑材料可以放置在衬底上的预制图案中。本发明的各种实施方式所采用的聚合物的化学结构在此处描述。
• Novel Reagents for Directed Biomarker Signal Amplification
  申请人：Gaylord Brent S.

  公开号：US20110257374A1

  公开（公告）日：2011-10-20

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述了涉及中性共轭聚合物的方法、组合物和制造品，包括合成带有连接物的中性共轭水溶性聚合物的方法，以及端基封闭单元。这些聚合物可用于制造新型光电器件，以及开发高效的生物传感器。本发明进一步涉及这些聚合物在测定方法中的应用。
• Reagents for directed biomarker signal amplification
  申请人：Gaylord Brent S.

  公开号：US08362193B2

  公开（公告）日：2013-01-29

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述了涉及中性共轭聚合物的方法、组合物和制造品，包括合成带有连接物的中性共轭水溶性聚合物的方法，以及端基覆盖单元。这种聚合物可以用于制造新型光电器件和高效生物传感器的开发。本发明还涉及这些聚合物在测定方法中的应用。