indolo[3,2-b]carbazole-6-carboxylic acid | 744207-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: indolo[3,2-b]carbazole-6-carboxylic acid
• 英文别名: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxylic acid；5,11-dihydroindolo[3,2-b]carbazole-12-carboxylic acid
• CAS: 744207-11-2
• 化学式: C₁₉H₁₂N₂O₂
• 分子量: 300.316
• InChiKey: LCYJXEOHLAEURY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.9
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以93%的产率得到indolo[3,2-b]carbazole-6-carboxylic acid
  参考文献：
  名称：

  Ah受体配体6-甲酰吲哚[3,2-b]咔唑代谢物的合成

  摘要：

  描述了芳烃受体高亲和力配体 6-甲酰基吲哚并 [3,2-b] 咔唑的五种单羟基化和二羟基化代谢物的合成。代谢物的结构是...

  DOI：

  10.1002/ejoc.200400087

文献信息

• Detection method and kit
  申请人：The European Union, represented by the European Commission

  公开号：EP3064946A1

  公开（公告）日：2016-09-07

  Uses of ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate as a fluorescent ligand probe, preferably in a binding assay for quantitative analysis in combination with a recombinant aryl hydrocarbon receptor (AhR) protein. A method for detection or quantitative analysis of suspected aryl hydrocarbon receptor (AhR) ligands in a sample, the method comprising the steps of: (a) providing a sample possibly containing at least one known or unknown AhR ligand; (b) mixing said sample with a composition comprising a recombinant AhR protein bound to ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate; and (c) determining the presence or the total amount of said at least one known or unknown AhR ligand in the sample by fluorescence spectroscopy. Use e.g. for screening of unknown compounds to determine their binding ability to AhR; for analyzing unknown chemical mixtures to assess the presence of ligands able to bind to AhR; for screening of Polycyclic Aromatic Hydrocarbon (PAHs) from water, food or sediment; for screening of PAHs or dioxin-like compounds in water, food or sediment; for testing for pollutant removal in water and waste water treatment plants; for testing for water reuse; for testing the presence of dioxin-like compounds in incinerator plants; or for testing of bodily fluids of humans or animals exposed to PAHs or dioxin-like compounds.

  5,11-二氢吲哚并[3,2-b]咔唑-6-羧酸乙酯作为荧光配体探针的用途，优选与重组芳基烃受体（AhR）蛋白结合进行定量分析的结合测定。一种检测或定量分析样品中可疑芳基烃受体（AhR）配体的方法，该方法包括以下步骤(a) 提供可能含有至少一种已知或未知 AhR 配体的样品；(b) 将所述样品与包含与 5,11-二氢吲哚并[3,2-b]咔唑-6-羧酸乙酯结合的重组 AhR 蛋白的组合物混合；以及 (c) 通过荧光光谱测定样品中所述至少一种已知或未知 AhR 配体的存在或总量。例如筛选未知化合物，确定其与 AhR 的结合能力；分析未知化学混合物，评估是否存在能够与 AhR 结合的配体；筛选水、食物或沉积物中的多环芳香烃（PAHs）；筛选水、食物或沉积物中的多环芳香烃或二恶英类化合物；用于检测水和废水处理厂的污染物去除情况；用于检测水的再利用情况；用于检测焚化炉中是否存在二恶英类化合物；或用于检测暴露于多环芳烃或二恶英类化合物的人类或动物的体液。
• DETECTION METHOD AND KIT
  申请人：The European Union, represented by the European Commission

  公开号：EP3265816A1

  公开（公告）日：2018-01-10
• WNT MODULATORS FOR THE PROTECTION, MITIGATION AND TREATMENT OF RADIATION INJURY
  申请人：University of Southern California

  公开号：US20160074400A1

  公开（公告）日：2016-03-17

  Provided are composition and methods for treating radiation-induced cell damage, and in particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced induced depletion of tissue stem cells and injury to the supportive stem cell niche, and in even more particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced gastrointestinal syndrome (RIGS), comprising sequential administration of a Wnt pathway activator/agonist (e.g., Rspo1 or a small molecule inducer thereof) that amplifies the surviving intestinal stem cell (ISC) pool post-radiation exposure, followed by a selective antagonist of the β-Catenin-CBP interaction (e.g., ICG-001 or other exemplary compounds disclosed herein) that accelerates differentiation of the stimulated (e.g., Rspo1-stimulated) ISC in crypt-villi axis, promoting villous regeneration and intestinal restitution, thereby mitigating RIGS. Adjunctive and combination therapy embodiments are encompassed.
• [EN] DETECTION METHOD AND KIT<br/>[FR] MÉTHODE ET KIT DE DÉTECTION
  申请人：EUROPEAN UNION REPRESENTED BY THE EUROPEAN COMMISSION

  公开号：WO2016142252A1

  公开（公告）日：2016-09-15

  Uses of ethyl 5,11-dihydroindolo[3,2-b]carbazole-6-carboxylate as a fluorescent ligand probe, preferably in a binding assay for quantitativeanalysis in combination with a recombinant aryl hydrocarbon receptor (AhR) protein. A method for detection or quantitative analysis of suspected aryl hydrocarbon receptor (AhR) ligands in a sample, the method comprising the steps of: (a) providing a sample possibly containing at least one known or unknown AhR ligand; (b) mixing said sample with a composition comprising a recombinant AhR protein bound to ethyl,511-dihydroindolo[3,2-b]carbazole-6-carboxylate; and (c) determining the presence or the total amount of said at least one known or unknown AhR ligand in the sample by fluorescence spectroscopy. Use e.g. for screening of unknown compounds to determine their binding ability to AhR; for analyzing unknown chemical mixtures to assess the presence of ligands able to bind to AhR; for screening of Polycyclic Aromatic Hydrocarbon (PAHs) from water, foodor sediment; for screening of PAHs or dioxin-like compounds in water, food or sediment; for testing for pollutant removal in water and waste water treatment plants; for testing for water reuse; for testing the presence of dioxin-like compounds in incinerator plants; or for testing of bodily fluids of humans or animals exposed to PAHs or dioxin-like compounds.
• Synthesis of Metabolites of the Ah Receptor Ligand 6-Formylindolo[3,2-b]carbazole
  作者：Niklas Wahlström、Ivan Romero、Jan Bergman

  DOI：10.1002/ejoc.200400087

  日期：2004.6

  Synthesis of the five mono- and di-hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6-formylindolo[3,2-b]carbazole is described. The structures of the metabolites were ...

  描述了芳烃受体高亲和力配体 6-甲酰基吲哚并 [3,2-b] 咔唑的五种单羟基化和二羟基化代谢物的合成。代谢物的结构是...