| 400031-76-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• CAS: 400031-76-7
• 化学式: C₁₈H₁₃BrClN₃O
• 分子量: 402.678
• InChiKey: UDHDOOUDUZIVBH-UHFFFAOYSA-N

物化性质

• 沸点：
  522.1±50.0 °C(Predicted)
• 密度：
  1.534±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.51
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.0
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 ammonium sulfate 作用下， 以 二苯醚 、 甲苯 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  SYNTHESIS OF SOME 2-THIOXOPYRIDO[2,3-d]PYRIMIDINE RIBOFURANOSIDES AND THEIR ANTIMICROBIAL ACTIVITY

  摘要：

  2-Thioxo-3,5,7-trisubstituted-1-[2',3',5'-tri-O-benzoyl-beta -D-ribofuranosyl]pyrido [2,3-d]pyrimidin-4(1H)-ones have been prepared by the condensation of trimethylsilyl derivative of w2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with P-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by JR, H-1 NMR and elemental analysis. These derivatives, have been screened for their antimicrobial activity.

  DOI：

  10.1080/10426500108040270
• 作为产物：
  描述：

  1-(4-溴苯基)-3-(4-氯苯基)-2-丙烯-1-酮 在 乙酸铵 、 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  SYNTHESIS OF SOME 2-THIOXOPYRIDO[2,3-d]PYRIMIDINE RIBOFURANOSIDES AND THEIR ANTIMICROBIAL ACTIVITY

  摘要：

  2-Thioxo-3,5,7-trisubstituted-1-[2',3',5'-tri-O-benzoyl-beta -D-ribofuranosyl]pyrido [2,3-d]pyrimidin-4(1H)-ones have been prepared by the condensation of trimethylsilyl derivative of w2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with P-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by JR, H-1 NMR and elemental analysis. These derivatives, have been screened for their antimicrobial activity.

  DOI：

  10.1080/10426500108040270

文献信息

• Focused microwave-assisted efficient and convenient synthesis of new pyrido[2,3-<i>d</i>]pyrimidinone derivatives
  作者：Zheng-Jun Quan、Jun-Ling Liang、Lin Bai、Zhang Zhang、Yu-Xia Da、Xi-Cun Wang

  DOI：10.1515/hc-2012-0131

  日期：2012.12.1

  Abstract A rapid and efficient method for the preparation of new pyrido[2,3-d]pyrimidinone derivatives by the condensation of 2-amino-4-aryl-6-arylnicotinamides with carbon disulfide or cycloalkanones under focused microwave irradiation is described.

  摘要 描述了一种通过 2-氨基-4-芳基-6-芳基烟酰胺与二硫化碳或环烷酮在聚焦微波辐射下缩合制备新型吡啶并[2,3-d]嘧啶酮衍生物的快速有效方法。
• Molecular Iodine Promoted Synthesis of New Pyrido[2,3-d]pyrimidin-4-ols
  作者：Xicun Wang、Junling Liang、Zhengjun Quan、Lin Bai

  DOI：10.1002/cjoc.201180294

  日期：2011.8

  A highly ef?cient synthesis of novel pyrido[2,3‐d]pyrimidin‐4‐ols was developed via an iodine‐catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3‐d]pyrimidin‐4‐ols were obtained from easily available 2‐amino‐4‐aryl‐6‐arylnicotinamides and benzylic amines with good to excellent yields.

  在聚焦微波辐射下，通过碘催化的串联氧化环化反应开发了高效的新型吡啶并[2,3 - d ]嘧啶-4-醇。从容易获得的2-氨基-4-芳基-6-芳基烟酰胺和苄基胺中制得Pyrido [2,3 - d ]嘧啶-4-醇，收率好至极好。