2-(1-chloro-ethyl)-fluorene | 42914-78-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-(1-chloro-ethyl)-fluorene
• 英文别名: 2-(1-Chlor-aethyl)-fluoren；2-(1-chloroethyl)-9H-fluorene；1-Fluoren-2-yl-aethylchlorid
• CAS: 42914-78-3
• 化学式: C₁₅H₁₃Cl
• 分子量: 228.721
• InChiKey: KTAMXLCAEMVOKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  二氧化碳 、 2-(1-chloro-ethyl)-fluorene 在 salcomine 、 四丁基高氯酸铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 5.0 ℃ 、101.32 kPa 条件下， 以84%的产率得到环洛芬
  参考文献：
  名称：

  Electrosynthesis of 2‐Arylpropionic Acids from α‐Methylbenzyl Chlorides and Carbon Dioxide by [Co(Salen)]

  摘要：

  The electrochemical synthesis of the 2-arylpropionic acid group of nonsteroidal anti-inflammatory agents such as ibuprofen, naproxen, indoprofen, biprofen, cicloprofen, and fenoprofen has been carried out in dimethylformamide (DMF) containing tetra-n-butylammonium perchlorate (nBu(4)NClO(4)) by electrochemical carboxylation of alpha-methylbenzyl chlorides catalyzed by a schiff-base complex [Co(salen)] in an undivided cell equipped with a platinum cathode and magnesium anode under constant current density of 10 mA/cm(2) in good yields. Cyclic voltammetric studies have also been carried out to investigate the mechanism by which [Co(salen)] catalyzes the cathodic reaction of a-methylbenzyl chlorides in presence Of CO2 by taking alpha-phenylethylchloride as the model compound.

  DOI：

  10.1081/scc-200054748
• 作为产物：
  描述：

  2-乙酰芴 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-(1-chloro-ethyl)-fluorene
  参考文献：
  名称：

  替代效应。十三、1-(7-取代的 2-芴基)乙基氯化物的溶剂分解和 7-取代的 2-芴羧酸乙酯的碱水解

  摘要：

  (i) 1-(7-取代 2-芴基)乙基氯在 90% 和 80% 丙酮水溶液中的溶剂分解和 (ii) 7-取代 2-芴羧酸乙酯在 85% 乙醇水溶液中的碱水解的两组速率常数已经确定。两种取代基效应都与 LArSR 关系密切相关；在相同条件下，所得 r+ 值（分别为 0.82 和 0.47）与相应联苯基系统中的 r+ 值相当。ρπ+ 值的比较清楚地表明芴基比联苯基系统更有效地传递π电子效应（1:0.75）。这可以归因于后一个 pi 系统中的扭曲因素。发现 Pi 效应传输的衰减是独立于反应的介入 pi 系统的特征：1。

  DOI：

  10.1246/bcsj.51.601

文献信息

• Chlorination of Benzylic and Allylic Alcohols with Trimethylsilyl Chloride Enhanced by Natural Sodium Montmorillonite
  作者：Makoto Onaka、Michael Tandiary、Yoichi Masui

  DOI：10.1055/s-0034-1379226

  日期：——

  method for the efficient chlorination of tertiary, secondary, and primary benzylic and allylic alcohols is described. The method is characterized by the formation of hydrogen chloride from trimethylsilyl chloride and trace water, the formation of a carbenium ion through the protonation of an alcohol and subsequent dehydration, and the chlorination of the carbenium ion. During the process, sodium ion-exchanged

  描述了一种有效氯化叔、仲和伯苄醇和烯丙醇的新的实用方法。该方法的特点是三甲基氯硅烷与微量水生成氯化氢，醇质子化后脱水生成碳鎓离子，碳鎓离子氯化。在此过程中，钠离子交换蒙脱石在捕获生成的氯化氢、稳定碳鎓中间体以及促进氯化方面起着至关重要的作用。
• One-step syntheses of macrocyclic compounds: A short review
  作者：Krzysztof E. Krakowiak、Reed M. Izatt、Jerald S. Bradshaw

  DOI：10.1002/jhet.5570380601

  日期：2001.11

  reactions involving the formation of four to twenty or more new covalent bonds. The new macrocycles reviewed include cyclophanes, biscrown ethers, cryptands, macrolides, cage compounds, calixarenes, homocalixarenes, cucubiturils, and supercryptands all prepared by one-step syntheses.

  大环配体已经通过各种一步环寡聚方法制备。这篇简短的综述涵盖了一步式环化反应，涉及形成四到二十个或更多个新的共价键。审查的新的大环化合物包括环烷，双冠醚，穴状配体，大环内酯类，笼状化合物，杯芳烃，高杯芳烃，cububiturils和supercryptands，均通过一步合成制备。
• Azole derivative and pharmaceutical composition thereof
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US05807880A1

  公开（公告）日：1998-09-15

  An azole derivative represented by the following general formula (I) ##STR1## (symbols in the formula have the following meanings; R.sup.1 and R.sup.2 : the same or different from each other and each represents a hydrogen atom, a lower alkyl group or a phenyl group which may be substituted with a halogen atom, A, B and D: the same or different from one another and each represents a group represented by the formula ##STR2## or a nitrogen atom, X and Y: the same or different from each other and each represents a single bond, a methylene group, an oxygen atom, a group represented by a formula S(O).sub.n, or a group represented by the formula ##STR3## R.sup.3 and R.sup.4 : the same or different from each other and each represents a hydrogen atom or a lower alkyl group, and n: 0, 1 or 2), a salt thereof, a hydrate thereof or a solvate thereof. This compound has a function to inhibit steroid 17-20 lyase and is useful as preventive and treating agents for prostatic cancer, prostatic hypertrophy, virilism, breast cancer, mastopathy, histeromyoma, and endometriosis.

  以下是一种由下列通式（I）表示的唑类衍生物 ##STR1## （式中符号的含义如下：R.sup.1和R.sup.2：相同或不同，每个代表氢原子，低级烷基或苯基，可以用卤原子取代；A、B和D：相同或不同，每个代表由以下公式表示的基团##STR2##或氮原子；X和Y：相同或不同，每个代表单键，亚甲基基团，氧原子，由公式S（O）.sub.n表示的基团，或由以下公式表示的基团##STR3##；R.sup.3和R.sup.4：相同或不同，每个代表氢原子或低级烷基；n：0、1或2），其盐、水合物或溶剂化物。该化合物具有抑制类固醇17-20裂解酶的作用，并可用作前列腺癌、前列腺肥大症、男性化、乳腺癌、乳房病、子宫肌瘤和子宫内膜异位症的预防和治疗剂。
• AZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0721943A1

  公开（公告）日：1996-07-17

  An azole derivative represented by the following general formula (I) a salt thereof, a hydrate thereof or a solvate thereof. This compound has a function to inhibit steroid 17-20 lyase and is useful as preventive and treating agents for prostatic cancer, prostatic hypertrophy, virilism, breast cancer, mastopathy, histeromyoma, and endometriosis.

  由以下通式（I）代表的唑衍生物 其盐、水合物或溶液。 该化合物具有抑制类固醇 17-20 裂解酶的功能，可作为前列腺癌、前列腺肥大症、男性化 症、乳腺癌、乳腺增生症、子宫内膜异位症的预防和治疗药物。
• BOKOVA, A. I.;BADZYU, M., SINTEZ, SVOJSTVA I MODIF. SINTET. I PRIROD. ORGAN. SOED. SB. NAUCH. TR., +
  作者：BOKOVA, A. I.、BADZYU, M.

  DOI：——

  日期：——