1-(4-bromophenyl)-4-(4-methylpiperazin-1-yl)phthalazine | 1351858-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(4-bromophenyl)-4-(4-methylpiperazin-1-yl)phthalazine
• 英文别名: 1-(4-Bromophenyl)-4-(4-methylpiperazin-1-yl)phthalazine
• CAS: 1351858-32-6
• 化学式: C₁₉H₁₉BrN₄
• 分子量: 383.291
• InChiKey: LZYGFQUQJLFFSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(4-溴苯基)-1(2H)-酞嗪酮 在 三氯氧磷 作用下， 以 正丁醇 为溶剂， 反应 5.0h， 生成 1-(4-bromophenyl)-4-(4-methylpiperazin-1-yl)phthalazine
  参考文献：
  名称：

  Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

  摘要：

  A series of new phthalazine derivatives 3a-i and 4a-c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a-c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 mu mol.

  DOI：

  10.1007/s00044-011-9874-z