3-isothiocyanato-benzopyran-2-one | 1207840-62-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-isothiocyanato-benzopyran-2-one
• 英文别名: Coumarin isothiocyanate；3-isothiocyanatochromen-2-one
• CAS: 1207840-62-7
• 化学式: C₁₀H₅NO₂S
• 分子量: 203.221
• InChiKey: XURBASQTEDKTKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二硫化碳 、 3-氨基香豆素 在 吡啶 、 碘 作用下， 以69%的产率得到3-isothiocyanato-benzopyran-2-one
  参考文献：
  名称：

  由氨基香豆素简便合成异硫氰酸香豆素酯

  摘要：

  描述了使用二硫化碳、碘和吡啶将氨基香豆素一锅法转化为相应的异硫氰酸香豆素酯。在该反应中，吡啶作为溶剂和催化剂产生异硫氰酸香豆素酯。优异的收率、短的反应时间和温和的反应条件使该方法成为一锅法制备异硫氰酸香豆素酯的有用合成方法。

  DOI：

  10.1080/00397910902916080

文献信息

• Assay method employing fluorescent cell incorporative dye
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0176252B1

  公开（公告）日：1991-04-24
• MEANS AND METHODS FOR SINGLE MOLECULE PEPTIDE SEQUENCING
  申请人：VIB VZW

  公开号：EP3688152A1

  公开（公告）日：2020-08-05
• SYSTEMS AND METHODS FOR HOME TRANSDERMAL ASSESSMENT OF GASTROINTESTINAL FUNCTION
  申请人：MediBeacon Inc.

  公开号：US20220022820A1

  公开（公告）日：2022-01-27

  Disclosed herein is a non-transitory computer-readable media having computer-executable instructions thereon. When executed by the processor of a mobile computing device, the computer-executable instructions cause the processor to wirelessly communicatively couple the mobile computing device to a GI sensor (optionally by displaying instructions on a pairing screen), display a sensor placement screen that instructs the user to place the GI sensor on a body of a patient, prompts the user to administer a GI agent into the body of the patient; transmit a signal from the mobile computing device to the GI sensor to cause the GI sensor to initiate collection of light absorbance data for calculating GI function of the patient; receive light absorbance data from the GI sensor, and store the received light absorbance data.
• US4748129A
  申请人：——

  公开号：US4748129A

  公开（公告）日：1988-05-31
• [EN] MEANS AND METHODS FOR SINGLE MOLECULE PEPTIDE SEQUENCING<br/>[FR] MOYENS ET PROCÉDÉS DE SÉQUENÇAGE DES PEPTIDES D'UNE SEULE MOLÉCULE
  申请人：VIB VZW

  公开号：WO2019063827A1

  公开（公告）日：2019-04-04

  The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses means and methods for single molecule protein sequencing and/or amino acid identification using cleavage inducing agent. Said cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the kinetics of said reaction.