1-[2-[(3,5-Ditert-butyl-4-hydroxyphenyl)methylamino]ethyl]-3-hydroxy-2-methylpyridin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-[(3,5-Ditert-butyl-4-hydroxyphenyl)methylamino]ethyl]-3-hydroxy-2-methylpyridin-4-one
• 化学式: C₂₃H₃₄N₂O₃
• 分子量: 386.535
• InChiKey: RWGPIPUFHDTADL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  72.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-二叔丁基-4-羟基苯甲醛 在 palladium on activated charcoal 氢气 、 sodium cyanoborohydride 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 1-[2-[(3,5-Ditert-butyl-4-hydroxyphenyl)methylamino]ethyl]-3-hydroxy-2-methylpyridin-4-one
  参考文献：
  名称：

  Prodrug and covalent linker strategies for the solubilization of dual-Action antioxidants/Iron chelators

  摘要：

  Water soluble prodrugs of hybrid free radical scavenger/iron chelating molecules, based on 3,5-disubstituted-4-hydroxyphenyl derivatives and 3-hydroxy-2-methyl-4(1H)-pyridinone (deferiprone), have been prepared. Related hybrid molecules containing a covalent poly(ethylene)glycol or an amine linker were also synthesized. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00698-4

文献信息

• Prodrug and covalent linker strategies for the solubilization of dual-Action antioxidants/Iron chelators
  作者：David Bebbington、Claire E Dawson、Suneel Gaur、John Spencer

  DOI：10.1016/s0960-894x(02)00698-4

  日期：2002.11

  Water soluble prodrugs of hybrid free radical scavenger/iron chelating molecules, based on 3,5-disubstituted-4-hydroxyphenyl derivatives and 3-hydroxy-2-methyl-4(1H)-pyridinone (deferiprone), have been prepared. Related hybrid molecules containing a covalent poly(ethylene)glycol or an amine linker were also synthesized. (C) 2002 Elsevier Science Ltd. All rights reserved.