N-(2-benzyl-8-hydroxy-5,6-dihydrobenzo[f]quinoxalin-3-yl)-2-(4-hydroxyphenyl)acetamide | 132063-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-benzyl-8-hydroxy-5,6-dihydrobenzo[f]quinoxalin-3-yl)-2-(4-hydroxyphenyl)acetamide
• CAS: 132063-60-6
• 化学式: C₂₇H₂₃N₃O₃
• 分子量: 437.498
• InChiKey: BXJZXXNWLVLLFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  95.3
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(4-羟基苯基)乙酰氯 生成 N-(2-benzyl-8-hydroxy-5,6-dihydrobenzo[f]quinoxalin-3-yl)-2-(4-hydroxyphenyl)acetamide
  参考文献：
  名称：

  TERANISHI, KATSUNORI;GOTO, TOSHIO, BULL. CHEM. SOC. JAP., 63,(1990) N1, C. 3132-3140

  摘要：

  DOI：

文献信息

• Synthesis and Chemiluminescence of Coelenterazine (<i>Oplophorus</i>Luciferin) Analogues
  作者：Katsunori Teranishi、Toshio Goto

  DOI：10.1246/bcsj.63.3132

  日期：1990.11

  In the case of chemiluminescence of coelenterazine, effects of conformation rigidity of and hydrogen bonding with the emitter, coelenteramide, on the chemiluminescence efficiency have been examined with several coelenterazine analogues synthesized. Conformational rigidity has a light enhancing effect, whereas decreasing light yield was observed by hydrogen-bond formation with the emitter.

  就腔肠素的化学发光而言，我们利用合成的几种腔肠素类似物研究了发光体腔肠酰胺的构象刚性和氢键对化学发光效率的影响。构象刚性具有增光作用，而与发射体形成氢键则会降低光产率。
• FLUORESCENT PROTEIN
  申请人：Chisso Corporation

  公开号：EP1666488B1

  公开（公告）日：2010-11-17
• Fluorescent Proteins
  申请人：Inouye Satoshi

  公开号：US20110070656A1

  公开（公告）日：2011-03-24

  A fluorescent protein (bFP) having chemiluminescence activity is a complex composed of the apoprotein of a calcium-binding photoprotein, coelenteramid or an analog thereof, and calcium ions or divalent or trivalent ions that can be substituted for the calcium ions. In the complex, the ratio of the number of molecules of the apoprotein to that of the coelenteramid is 1:1 and the ratio of the number of molecules of the apoprotein to that of the divalent or trivalent ions is 1:1 to 1:4. The fluorescent protein is used as a marker because it catalyzes luminescence of coelenterazine and has fluorescence capability. Removal of calcium ions etc. from this fluorescent protein (bFP) having luminescence activity provides a novel fluorescent protein (gFP). Mixing this gFP with the coelenterazine provides a calcium-binding photoprotein, which emit light instantaneously, enabling use as a marker.