(3-carboxy-cyclopentyl)-acetic acid | 6786-01-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3-carboxy-cyclopentyl)-acetic acid
• 英文别名: Cyclopentan-carbonsaeure-(1)-essigsaeure-(3)；(3-Carboxy-cyclopentyl)-essigsaeure；3-Carboxy-cyclopentyl-essigsaeure；3-Carboxycyclopentanessigsaeure；(1S,3S)-3-carboxy-cyclopentaneacetic acid；3-(carboxymethyl)cyclopentane-1-carboxylic acid
• CAS: 6786-01-2
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: XCWAHKNNDFNCCV-UHFFFAOYSA-N

物化性质

• 熔点：
  85 °C
• 沸点：
  390.6±15.0 °C(Predicted)
• 密度：
  1.293±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3-carboxy-cyclopentyl)-acetic acid 在 五氯化磷 作用下， 生成 (3-phenylcarbamoyl-cyclopentyl)-acetic acid anilide
  参考文献：
  名称：

  Hintikka; Komppa, Chemisches Zentralblatt, 1918, vol. 89, # II, p. 370

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 (3-carboxy-cyclopentyl)-acetic acid
  参考文献：
  名称：

  Hintikka; Komppa, Chemisches Zentralblatt, 1918, vol. 89, # II, p. 370

  摘要：

  DOI：

文献信息

• AQUEOUS INKJET INK COMPOSITION
  申请人：JETBEST Corporation

  公开号：EP3202863A1

  公开（公告）日：2017-08-09

  An aqueous inkjet ink composition is disclosed and includes a dye based polymeric dispersant, an aqueous organic solvent, at least one additive and water for application of inkjet printing specific patterns on various texture products. The dye based polymeric dispersant is present in an amount of from 2 to 30 percent by weight of the total weight of the inkjet ink composition, the aqueous organic solvent is 15 to 65 percent by weigh, and the at least one additive less than 2 percent by weigh. The dye based polymeric dispersant, the aqueous organic solvent and the at least one additive are dissolved or dispersed in water like distilled or de-ionized water. The present invention has features of good stability and not easily clogging at printerhead nozzles without a great deal of industrial waste water and a tedious and complex post treatment of water cleaning, thereby scaling down the manufacturing apparatus for digital fabric and increasing its popularity.

  本发明公开了一种水性喷墨墨水组合物，其中包括一种染料基聚合物分散剂、一种水性有机溶剂、至少一种添加剂和水，用于在各种纹理产品上喷墨打印特定图案。染料基聚合物分散剂的用量为喷墨墨水组合物总重量的 2%至 30%（按重量计），水性有机溶剂的用量为 15%至 65%（按重量计），至少一种添加剂的用量小于 2%（按重量计）。染料基聚合物分散剂、水性有机溶剂和至少一种添加剂溶解或分散在蒸馏水或去离子水等水中。本发明具有稳定性好、不易堵塞打印头喷嘴等特点，不需要大量的工业废水和繁琐复杂的水清洗后处理，从而简化了数码织物的生产设备，提高了数码织物的普及率。
• COMPOSITIONS, METHODS, AND ARTICLES RELATING TO IN-SITU CROSSLINKING OF POLYAMIDES DURING ADDITIVE MANUFACTURING
  申请人：Xerox Corporation

  公开号：EP4006080A1

  公开（公告）日：2022-06-01

  Particles may be produced that comprise an unsaturated polyamide and an initiator. Said particles may be used in additive manufacturing methods that comprise: depositing the particles optionally in combination with other thermoplastic polymer particles upon a surface; and once deposited, heating at least a portion of the particles to promote consolidation thereof and crosslinking of the unsaturated polyamide, thereby forming a consolidated body comprising a crosslinked polyamide.

  可生产由不饱和聚酰胺和引发剂组成的颗粒。所述颗粒可用于增材制造方法，该方法包括：将颗粒（可选择与其他热塑性聚合物颗粒一起）沉积在表面上；沉积后，加热至少一部分颗粒，以促进其固结和不饱和聚酰胺的交联，从而形成由交联聚酰胺组成的固结体。
• Cycloalkyl-linked diheterocycle derivatives
  申请人：PFIZER INC.

  公开号：US10125130B2

  公开（公告）日：2018-11-13

  The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

  本发明涉及式 (I) 的化合物 或其药学上可接受的盐，其中 A、L、D、R1-R15、w、x、y 和 z 在本文中定义。本发明的新型环烷基连环二杂环衍生物可用于治疗哺乳动物的异常细胞生长，如癌症。本发明还涉及含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗哺乳动物异常细胞生长的方法。
• The OxyArm™ — a new minimal contact oxygen delivery system for mouth or nose breathing
  作者：Elizabeth Ling、Lee McDonald、Tim R. J. Dinesen、Donald DuVall

  DOI：10.1007/bf03020531

  日期：2002.3

  Purpose: To describe the development and performance of a new minimal contact oxygen (O-2) delivery system for both nasal and oral breathing, with capnographic capabilities,Methods: The development and design challenges of the OxyArm(TM) (OA) prototype are described, The innovative design utilizes a headset with a semi-rigid boom and an O-2 diffuser. The OA was compared to the Venturi mask in eight healthy adults after informed consent. Inspired O-2 fractions were measured in the hypopharynx using continuous gas sampling at low to high O-2 flow rates. Mean data were compared using two-tailed paired t tests with significance set at 0.05,Results: The measured inspired 0 2 concentration was higher in the OA at 2 (26.3 +/- 2.5 vs 23.3 +/- 0.5, P <0.01) and 6 L.min(-1) (33.5 +/- 33 vs 28.8 +/- 1.2, P <0.01) flow rates, At 12 L.min(-1), the O-2 concentration was less in the OA (39.2 +/- 6.3 vs 46.0 +/- 2.7, P <0.02). All subjects found both systems comfortable for the short duration of the study.Conclusions: The OA delivered predictable concentrations of O-2 over low to medium flow rates. This system is comfortable, easy to use, non-obtrusive, odorless, and latex-free. The ability to monitor capnography makes this device ideal for monitored anesthesia care or in other settings (intensive care) where monitoring of respiration is warranted, This device does not contact the face and thus may be ideal for pediatric patients and those on long-term home O-2 therapy, Further clinical trials in these areas are warranted.
• CYCLOALKYL-LINKED DIHETEROCYCLE DERIVATIVES
  申请人：Pfizer Inc.

  公开号：EP3137460B1

  公开（公告）日：2019-10-23