1,4-Bis(6,6-dipropionylhexyloxy)benzene | 66619-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,4-Bis(6,6-dipropionylhexyloxy)benzene
• 英文别名: 4-[5-[4-(7-oxo-6-propanoylnonoxy)phenoxy]pentyl]heptane-3,5-dione
• CAS: 66619-83-8
• 化学式: C₃₀H₄₆O₆
• 分子量: 502.692
• InChiKey: ZHMUEOZXOKOLOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  36
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对苯二酚 、 4-(5-Bromopentyl)-3,5-heptanedione 在 potassium carbonate 、 potassium iodide 作用下， 以 丁酮 为溶剂， 生成 1,4-Bis(6,6-dipropionylhexyloxy)benzene
  参考文献：
  名称：

  Antiviral activity of some .beta.-diketones. 3. Aryl bis(.beta.-diketones). Antiherpetic activity

  摘要：

  A series of bis(beta-diketones) was synthesized and tested in vitro for antiviral actitity against herpes simplex type 2. Two parameters which were studied in an effort to optimize activity were the nature of the aryl group and the length of the alkyl bridge. One of the more active compounds, 4,4'-[(1,4-phenylenedioxy)bis(6,1-hexanediyl)]-bis[3,5-heptanedione] (6), was evaluated more extensively and found to inhibit the cytopathic effect in tissue culture of herpes simplex virus type 1 as well as type 2. Compound 6 was evaluated in vivo topically against herpes simplex type 1 in experimentally induced skin infections in guinea pigs. A topical treatment with 2% of 6 in a vanishing cream base, administered 24 h postinfection applied five times daily for 4 days, significantly reduced the number and size of herpetic vesicles.

  DOI：

  10.1021/jm00205a019

文献信息

• Arylenedioxy-bis-diketones
  申请人：Sterling Drug Inc.

  公开号：US04096280A1

  公开（公告）日：1978-06-20

  Phenylenedioxy-bis-dikeones having the formula ##STR1## useful as antiviral agents, are prepared by etherification of dihydric phenols and alkylation of beta-dikeones.

  具有以下公式的苯二酚基二酮 ##STR1## 作为抗病毒剂是有用的，它们是通过二元醇醚化和β-二酮烷基化制备的。
• DIANA G. D.; CARABATEAS P. M.; SALVADOR U. J.; WILLIAMS G. L.; ZALAY E. S+, J. MED. CHEM., 1978, 21, NO 7, 689-692
  作者：DIANA G. D.、 CARABATEAS P. M.、 SALVADOR U. J.、 WILLIAMS G. L.、 ZALAY E. S+

  DOI：——

  日期：——
• US4096280A
  申请人：——

  公开号：US4096280A

  公开（公告）日：1978-06-20
• Antiviral activity of some .beta.-diketones. 3. Aryl bis(.beta.-diketones). Antiherpetic activity
  作者：Guy D. Diana、Philip M. Carabateas、U. Joseph Salvador、Gordon L. Williams、Ethel S. Zalay、Francis Pancic、B. A. Steinberg、Joseph C. Collins

  DOI：10.1021/jm00205a019

  日期：1978.7

  A series of bis(beta-diketones) was synthesized and tested in vitro for antiviral actitity against herpes simplex type 2. Two parameters which were studied in an effort to optimize activity were the nature of the aryl group and the length of the alkyl bridge. One of the more active compounds, 4,4'-[(1,4-phenylenedioxy)bis(6,1-hexanediyl)]-bis[3,5-heptanedione] (6), was evaluated more extensively and found to inhibit the cytopathic effect in tissue culture of herpes simplex virus type 1 as well as type 2. Compound 6 was evaluated in vivo topically against herpes simplex type 1 in experimentally induced skin infections in guinea pigs. A topical treatment with 2% of 6 in a vanishing cream base, administered 24 h postinfection applied five times daily for 4 days, significantly reduced the number and size of herpetic vesicles.