2-乙酰氨基己酸 | 54896-21-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-乙酰氨基己酸
• 英文名称: N-acetyl-D-norleucine
• 英文别名: N-Acetyl-D-norleucin；D-2-Acetamino-capronsaeure；N-Acetyl-D-norleucine；(2R)-2-acetamidohexanoic acid
• CAS: 54896-21-8
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: JDMCEGLQFSOMQH-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  DL-正亮氨酸 反应 4.0h， 生成 2-乙酰氨基己酸
  参考文献：
  名称：

  l-methionine related l-amino acids by acylase cleavage of their corresponding

  摘要：

  Acylase I from Aspergillus oryzae is an even more useful enzyme than suggested so far. Besides standard amino acids such as L-Met, L-VaI and L-Phe, a number of additional sulfur-and selenium-containing amino acids can be obtained at useful reaction rates and in very high enantiomeric purity by kinetic resolution of the respective N-acety-DL-amino acids. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00400-x

文献信息

• Cobalt Ion Activation of Renal Acylase I
  作者：Robin Marshall、Sanford M. Birnbaum、Jesse P. Greenstein

  DOI：10.1021/ja01599a030

  日期：1956.9
• The Resolution of Amino Acids. II. Isoleucine, Alloisoleucine, Leucine and Norleucine¹
  作者：W. A. Hooper Huffman、A. W. Ingersoll

  DOI：10.1021/ja01151a111

  日期：1951.7
• [EN] METHODS FOR THE SYNTHESIS OF ALKYNE-CONTAINING DICARBA BRIDGES IN PEPTIDES<br/>[FR] PROCÉDÉS DE SYNTHÈSE DE PONTS DICARBA CONTENANT DES ALCYNES DANS DES PEPTIDES
  申请人：UNIV MONASH

  公开号：WO2011146974A1

  公开（公告）日：2011-12-01

  The present invention relates to methods for forming alkyne-containing dicarba bridges in peptides or between amino acids. This involves the use of a pair of complementary alkyne-containing metathesisable groups on the peptide(s) or amino acids, and subjecting the compound(s) to alkyne-metathesis. The alkyne-containing dicarba bridge may also be subjected to selective semi-hydrogenation, either directly or indirectly, to result in the formation of a product which is enriched in either the cis- or trans-alkene isomer.
• l-methionine related l-amino acids by acylase cleavage of their corresponding
  作者：Andreas S. Bommarius、Karlheinz Drauz、Kurt Günther、Günter Knaup、Michael Schwarm

  DOI：10.1016/s0957-4166(97)00400-x

  日期：1997.10

  Acylase I from Aspergillus oryzae is an even more useful enzyme than suggested so far. Besides standard amino acids such as L-Met, L-VaI and L-Phe, a number of additional sulfur-and selenium-containing amino acids can be obtained at useful reaction rates and in very high enantiomeric purity by kinetic resolution of the respective N-acety-DL-amino acids. (C) 1997 Elsevier Science Ltd.