N,N'-(2,2'-(2,2'-(biphenyl-2,2'-diylbis(oxy))bis(ethane-2,1-diyl))bis(sulfanediyl)bis(ethane-2,1-diyl))bis(2-(thiophen-2-yl)acetamide) | 1417914-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-(2,2'-(2,2'-(biphenyl-2,2'-diylbis(oxy))bis(ethane-2,1-diyl))bis(sulfanediyl)bis(ethane-2,1-diyl))bis(2-(thiophen-2-yl)acetamide)
• 英文别名: 2-thiophen-2-yl-N-[2-[2-[2-[2-[2-[2-[(2-thiophen-2-ylacetyl)amino]ethylsulfanyl]ethoxy]phenyl]phenoxy]ethylsulfanyl]ethyl]acetamide
• CAS: 1417914-64-7
• 化学式: C₃₂H₃₆N₂O₄S₄
• 分子量: 640.913
• InChiKey: RDWOFVJZQVEWJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  42
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  184
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,2'-二羟基联苯 在 lithium aluminium tetrahydride 、 sodium methylate 、 potassium carbonate 、 三乙胺 、 potassium iodide 、 lithium bromide 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 24.0h， 生成 N,N'-(2,2'-(2,2'-(biphenyl-2,2'-diylbis(oxy))bis(ethane-2,1-diyl))bis(sulfanediyl)bis(ethane-2,1-diyl))bis(2-(thiophen-2-yl)acetamide)
  参考文献：
  名称：

  Synthesis and biological evaluation of diamide derivatives of (S)-BINOL and biphenyl as potential anti-inflammatory/anti-arthritic agents

  摘要：

  A series of (S)-BINOL and biphenyl based diamides have been synthesized and characterized from analytic and spectral data. Anti-arthritic activity was studied by inhibition of protein denaturation method (Bovine serum albumin). All the diamides exhibit excellent anti-arthritic activity. Anti-inflammatory activity of the diamides synthesized was investigated using human red blood cells membrane stabilization method, and some of the diamides exhibit good anti-inflammatory activity.

  DOI：

  10.1007/s00044-012-0410-6