Thienopyridones as AMPK activators for the treatment of diabetes and obesity
申请人:Iyengar R. Rajesh
公开号:US20050038068A1
公开(公告)日:2005-02-17
The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties
作者:Claire Sablayrolles、Jean Claude Milhavet、Eliane Rechenq、Jean Pierre Chapat、Gerard H. Cros、Maurice Boucard、Jean J. Serrano、John H. McNeill
DOI:10.1021/jm00368a018
日期:1984.2
A series of imidazo[1,2-alpha]pyrazine derivatives was synthesized by condensation of alpha-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospasticactivities. On isolated atria, 5-bromoimidazo-[1,2-alpha]pyrazine showed positive chronotropic and inotropic
Total Synthesis of the <i>Aspidosperma</i> Alkaloid (±)-Subincanadine F via a Titanium-Mediated Intramolecular Nucleophilic Acyl Substitution Strategy
作者:Xiayun Cheng、Chelsea M. Duhaime、Stephen P. Waters
DOI:10.1021/jo1015823
日期:2010.10.15
The total synthesis of the bridge-fused Aspidosperma indole alkaloid (±)-subincanadine F has been accomplished in seven steps. The synthetic utility of a titanium-mediated intramolecular nucleophilic acyl substitution (INAS) reaction for the construction of the bridge-fused ringsystem was demonstrated.
[EN] PYRAZOLYL PYRROLINONES AND THEIR USE AS HERBICIDES<br/>[FR] PYRAZOLYLE PYRROLINONES ET LEUR UTILISATION EN TANT QU'HERBICIDES
申请人:SYNGENTA PARTICIPATIONS AG
公开号:WO2015018434A1
公开(公告)日:2015-02-12
The invention relates to pyrrolone compounds of the formula (I) wherein X, Ra, Rb, Rc, R1, R2 and R3 are as defined in the specification. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (I), to herbicidal compositions comprising these compounds and to methods of using these compounds to control plant growth.
A one-pot procedure for ring enlargement of α-chloromethyl<i>N</i>-containing heterocycles
作者:Lianyou Zheng、Jinbao Xiang、Xu Bai
DOI:10.1002/jhet.5570430211
日期:2006.3
A simple one-pot procedure for ringenlargement of α-chloromethyl N-containing heterocycles has been developed. By reaction of chloromethyl tetrahydroisoquinoline and its thieno analog with benzyl or allyl bromide under basic conditions, ring expansion and N-substitution were achieved simultaneously. The key to the transformation was proposed to involve the formation of aziridinium salt and subsequent