methyl (2S,5S,6S)-6-(4-bromophenyl)-5-methylpiperidine-2-carboxylate | 916914-95-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S,5S,6S)-6-(4-bromophenyl)-5-methylpiperidine-2-carboxylate
• CAS: 916914-95-9
• 化学式: C₁₄H₁₈BrNO₂
• 分子量: 312.206
• InChiKey: JIYFJSRBYUOTKB-XDTLVQLUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl (2S,5S,6S)-6-(4-bromophenyl)-5-methylpiperidine-2-carboxylate 在 4-甲基苯磺酸吡啶 、 magnesium triflate 作用下， 以 乙腈 、 苯 为溶剂， 反应 27.0h， 生成 (3S,6S,7S,9aS)-3-(azidomethyl)-6-(4-bromophenyl)-7-methyl-hexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one
  参考文献：
  名称：

  Stereochemical and Skeletal Diversity Employing Pipecolate Ester Scaffolds

  摘要：

  [GRAPHICS]The stereocontrolled synthesis of pyridooxazinones by Mg(OTf)(2)-promoted epoxide ring-opening with use of chiral pipecolates as nucleophiles is described. Pyridooxazinone products derived from azido-epoxides can be further rearranged to seven-membered pyridodiazepinones by azide reduction. The sequence of functional group interconversions generates diversity through topological and stereochemical variation.

  DOI：

  10.1021/ol070321g
• 作为产物：
  描述：

  (2S,5S,6S)-6-(4-Bromo-phenyl)-5-methyl-1-(2,2,2-trifluoro-acetyl)-piperidine-2-carboxylic acid methyl ester 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.67h， 以675 mg的产率得到methyl (2S,5S,6S)-6-(4-bromophenyl)-5-methylpiperidine-2-carboxylate
  参考文献：
  名称：

  Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets

  摘要：

  A convergent approach to highly functionalized diketopiperazines (DKPs) using enantioenriched pipecolic acids is described. Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well-defined building blocks. A resin "catch and release" strategy was devised to convert annulation products to pipecolic acid monomers. Complex diketopiperazines were efficiently assembled utilizing one-pot cyclodimerization of pipecolic acids. Massively parallel screening of the complex DKPs against a panel of molecular targets identified novel ligands for a number of G-protein-coupled receptors (GPCRs).

  DOI：

  10.1021/jo061758p

文献信息

• Stereochemical and Skeletal Diversity Employing Pipecolate Ester Scaffolds
  作者：Yu Chen、John A. Porco,、James S. Panek

  DOI：10.1021/ol070321g

  日期：2007.4.1

  [GRAPHICS]The stereocontrolled synthesis of pyridooxazinones by Mg(OTf)(2)-promoted epoxide ring-opening with use of chiral pipecolates as nucleophiles is described. Pyridooxazinone products derived from azido-epoxides can be further rearranged to seven-membered pyridodiazepinones by azide reduction. The sequence of functional group interconversions generates diversity through topological and stereochemical variation.
• Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets
  作者：Sivaraman Dandapani、Ping Lan、Aaron B. Beeler、Scott Beischel、Athier Abbas、Bryan L. Roth、John A. Porco,、James S. Panek

  DOI：10.1021/jo061758p

  日期：2006.11.1

  A convergent approach to highly functionalized diketopiperazines (DKPs) using enantioenriched pipecolic acids is described. Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well-defined building blocks. A resin "catch and release" strategy was devised to convert annulation products to pipecolic acid monomers. Complex diketopiperazines were efficiently assembled utilizing one-pot cyclodimerization of pipecolic acids. Massively parallel screening of the complex DKPs against a panel of molecular targets identified novel ligands for a number of G-protein-coupled receptors (GPCRs).