d,l-cis-piperidine-2,3-dicarboxylic acid,diethyl ester | 99319-04-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: d,l-cis-piperidine-2,3-dicarboxylic acid,diethyl ester
• 英文别名: diethyl piperidine-2,3-(cis)-dicarboxylate；piperidine-2,3-dicarboxylic acid diethyl ester；Piperidin-2,3-dicarbonsaeure-diaethylester；d,l-cis-piperidine-2,3-dicarboxylic acid, diethyl ester；Diethyl 2,3-piperidinedicarboxylate；diethyl piperidine-2,3-dicarboxylate
• CAS: 99319-04-7
• 化学式: C₁₁H₁₉NO₄
• 分子量: 229.276
• InChiKey: FKJCYDJJFIKYIK-UHFFFAOYSA-N

物化性质

• 沸点：
  119-121 °C(Press: 3 Torr)
• 密度：
  1.0933 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  d,l-cis-piperidine-2,3-dicarboxylic acid,diethyl ester 在 sodium 、 potassium carbonate 、 甲苯 、 4-溴丁腈 作用下， 生成 9-oxo-octahydro-quinolizin-1-carboxylic acid methyl ester
  参考文献：
  名称：

  Clemo et al., Journal of the Chemical Society, 1931, p. 3190,3197

  摘要：

  DOI：
• 作为产物：
  描述：

  吡啶-2,3-二羧酸二乙酯 在 nickel kieselguhr-catalyst 、 甲基环己烷 作用下， 150.0 ℃ 、29.42 MPa 条件下， 生成 d,l-cis-piperidine-2,3-dicarboxylic acid,diethyl ester
  参考文献：
  名称：

  Hydrogenation of Derivatives of Pyridine

  摘要：

  DOI：

  10.1021/ja01326a063

文献信息

• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines
  申请人：Merck & Co., Inc.

  公开号：US05494919A1

  公开（公告）日：1996-02-27

  The present invention is directed to certain piperidine, pyrrolidine, and hexahydro-1H-azepine compounds of the general structural formula: ##STR1## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.5, A, W, X, Y, and n axe as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which s are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

  本发明涉及某些哌啶、吡咯啉和六氢-1H-氮杂环烃化合物，其一般结构式如下：其中R.sub.1、R.sub.3、R.sub.4、R.sub.5、A、W、X、Y和n如本文所定义。这些化合物促进人类和动物体内生长激素的释放。这种特性可用于促进食用动物的生长，使可食肉制品的生产更加高效，在人类中，可用于治疗生长激素分泌不足所导致的生理或医学状况，如生长激素缺乏儿童的矮小身材，并治疗通过生长激素的合成效应改善的医学状况。还公开了含有这些化合物作为活性成分的促生长激素释放组合物。
• AROMATIC POLYESTER
  申请人：Muroran Institute of Technology

  公开号：EP2479203A1

  公开（公告）日：2012-07-25

  The present invention provides an aromatic polyester which is substantially free from the occurrence of coloration and retains significantly high transparency even after being thermally processed at high temperature and which has high flowability. The aromatic polyester contains a polyhydric phenol residue and a residue of any one of aromatic polycarboxylic acid, halide thereof, and anhydride thereof, and terminals of the aromatic polyester have a structure represented by the formula -C(O)-R. The aromatic polyester has an end-capping rate of 90% or higher and a weight average molecular weight (Mw) ranging from 3,000 to 1,000,000.

  本发明提供了一种芳香族聚酯，该聚酯基本上不会发生着色，即使在高温热加工后仍能保持明显的高透明度，并且具有高流动性。芳香族聚酯含有多羟基苯酚残留物和芳香族多羧酸、其卤化物和其酸酐中任意一种的残留物，芳香族聚酯的端基具有式 -C(O)-R 所代表的结构。芳香族聚酯的端盖率为 90% 或更高，重量平均分子量（Mw）为 3,000 至 1,000,000 之间。
• Besthorn, Chemische Berichte, 1895, vol. 28, p. 3153
  作者：Besthorn

  DOI：——

  日期：——
• US8129493B2
  申请人：——

  公开号：US8129493B2

  公开（公告）日：2012-03-06