2-methyl-2-phenoxypropan-1-amine | 274686-25-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-methyl-2-phenoxypropan-1-amine
• 英文别名: β-phenoxy-isobutylamine；β-Phenoxy-isobutylamin
• CAS: 274686-25-8
• 化学式: C₁₀H₁₅NO
• mdl: MFCD11577413
• 分子量: 165.235
• InChiKey: XGVNLHVCMYHEFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-aziridine; picrate 、 苯酚 生成 2-methyl-2-phenoxypropan-1-amine
  参考文献：
  名称：

  Reactions of Ethylenimines. VI. Picrates

  摘要：

  DOI：

  10.1021/ja01624a049

文献信息

• [EN] SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS<br/>[FR] BENZIMIDAZOLE CARBOXAMIDES SUBSTITUÉS ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES MÉDICAUX
  申请人：BIAL BIOTECH INVEST INC

  公开号：WO2021055591A1

  公开（公告）日：2021-03-25

  The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

  这项发明提供了替代苯并咪唑羧酰胺及相关化合物，含有这些化合物的组合物，医疗工具包，以及使用这些化合物和组合物治疗患者的医疗疾病的方法，例如癌症、溶酶体贮积症、神经退行性疾病、炎症性疾病。
• Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4
  申请人：MERCK PATENT GMBH

  公开号：US20150361079A1

  公开（公告）日：2015-12-17

  The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.

  本发明涉及新型螺环喹唑啉衍生物，作为调节代谢型谷氨酸受体亚型4（mGluR4）的正向变构调节剂和/或改变谷氨酸水平或谷氨酸信号传导的药物。
• Process for the arylation of olefins
  申请人：——

  公开号：US20030050500A1

  公开（公告）日：2003-03-13

  The present invention encompasses a process for preparing arylolefins by reacting one or more arylamines with one or more organic nitrites, in the presence of one or more olefins which bear at least one hydrogen atom on the double bond and in the presence of acid and in the presence of palladium or one or more palladium compounds.

  本发明涵盖了一种制备芳基烯烃的方法，该方法通过在酸和钯或一种或多种钯化合物的存在下，将一种或多种芳基胺与一种或多种有机亚硝酸盐反应，同时存在至少一个双键上带有至少一个氢原子的烯烃。
• Substituted cyclohexyl carboxylic acid compounds
  申请人：SEIKAGAKU CORPORATION

  公开号：EP1616859A1

  公开（公告）日：2006-01-18

  Cyclic carboxylic acid derivatives represented by the general formula (II); wherein R1 is an amide group substituted with substituted or unsubstituted alkyl groups, substituted alkoxy groups, phenoxy group, 1-naphthyloxy group, 2-naphthyloxy group, substituted or unsubtituted alkenyl groups, substituted or unsubstituted amino groups, substituted or unsubstituted aromatic hydrocarbon groups or substituted or unsubstituted heterocyclic groups and A represents a saturated cyclic alkyl with 5 to 7 carbon atoms. The cyclic carboxylic acid derivatives of formula (II) are useful for the synthesis of cyclic amide derivatives useful as cathepsin K inhibitors.

  由通式 (II) 代表的环状羧酸衍生物； 其中 R1 是被取代或未取代的烷基、取代的烷氧基、苯氧基、1-萘氧基、2-萘氧基、取代或未取代的烯基、取代或未取代的氨基、取代或未取代的芳香烃基或取代或未取代的杂环基取代的酰胺基，A 代表具有 5 至 7 个碳原子的饱和环状烷基。 式（II）的环状羧酸衍生物可用于合成作为胰蛋白酶 K 抑制剂的环状酰胺衍生物。
• Hydroxycarboxylic acid derivatives
  申请人：SEIKAGAKU CORPORATION

  公开号：EP1616867A1

  公开（公告）日：2006-01-18

  Hydroxycarboxylic acid derivatives represented by the general formula (V); wherein: R1 represents a substituted C1-C12 alkyl group; a substituted C2-C6 alkenyl group; a substituted amino group; a substituted C1-C6 alkoxy group; a substituted C1-C6 alkylthio group; a substituted carbamoyl group; a substituted sulfonamide group; or a substituted amide group; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; the ring A represents a saturated cyclic alkyl group with 5 to 7 carbon atoms; The hydroxycarboxylic acid derivatives of formula (V) are useful for the synthesis of cyclic amide derivatives useful as cathepsin K inhibitors.

  通式 (V) 所代表的羟基羧酸衍生物； 其中 R1 代表取代的 C1-C12 烷基；取代的 C2-C6 烯基；取代的氨基；取代的 C1-C6 烷氧基；取代的 C1-C6 烷硫基；取代的氨基甲酰基；取代的磺酰胺基；或取代的酰胺基； R2 代表氢原子、取代或未取代的烷基、取代或未取代的芳烃基或取代或未取代的杂环基； 环 A 代表具有 5 至 7 个碳原子的饱和环状烷基； 式（V）的羟基羧酸衍生物可用于合成可用作 cathepsin K 抑制剂的环酰胺衍生物。