3-bromo-N-[4-chloro-2-[[(cyclopropylmethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide | 882401-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-bromo-N-[4-chloro-2-[[(cyclopropylmethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
• 英文别名: 3-bromo-N-[4-chloro-2-[[(cyclopropylmethyl)amino]carbonyl]-6-methyl-phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide；3-bromo-N-[4-chloro-2-[[(cyclopropylmethyl)amino]-carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide；5-bromo-N-[4-chloro-2-(cyclopropylmethylcarbamoyl)-6-methylphenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide
• CAS: 882401-50-5
• 化学式: C₂₁H₁₈BrCl₂N₅O₂
• 分子量: 523.216
• InChiKey: IHDORFGEPXUWJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  88.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 在 3-甲基吡啶 、 甲基磺酰氯 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 反应 4.0h， 生成 3-bromo-N-[4-chloro-2-[[(cyclopropylmethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
  参考文献：
  名称：

  Anthranilamide insecticides

  摘要：

  本公开涉及用于合成化合物的中间体化合物，其中所述化合物具有Formula 1的所有几何和立体异构体、N-氧化物和盐，其中J是苯基，可选地从R5中独立选择一个到四个取代基取代；或J是从J-1到J-8组成的羰基环；R4是C4-C12烷基环烷基、C5-C12烯基环烷基、C5-C12炔基环烷基、C4-C12环烷基烷基、C5-C12环烷基烯基、C5-C12环烷基炔基、C4-C12环烯基烷基或C4-C12烷基环烯基；每个可选地从CH3和卤素中选择一个到六个取代基取代；或者R4是C3-C5环氧烷基烷基、C3-C5硫代环氧烷基烷基、C4-C6环氧烷基烷基、C4-C6硫代环氧烷基烷基、3-环氧烷基或3-硫代环氧烷基，每个可选地从C1-C3烷基、C1-C3卤代烷基、卤素、CN、C2-C4烷氧羰基和C2-C4卤代烷氧羰基中选择一个到五个取代基；或者R4是C3-C5氮代环丙烷基、C4-C6氮代环氧烷基或3-氮代环氧烷基，每个具有连接到氮原子的R10，并可选地在碳原子上用一个到五个取代基独立选择从C1-C3烷基、C1-C3卤代烷基、卤素、CN、C2-C4烷氧羰基和C2-C4卤代烷氧羰基；以及R1a、R1b、R2、R3和R5如本公开所定义。

  公开号：

  EP2564706A1

文献信息

• LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES
  申请人：Gutsche Oliver

  公开号：US20100055084A1

  公开（公告）日：2010-03-04

  Disclosed are suspension concentrate compositions comprising by weight based on the total weight of the composition, (a) from about 0.1 to about 50% of one or more carboxamide arthropodicides that are solid at room temperature; (b) from 0 to about 50% of one or more biologically active agents other than the carboxamide arthropodicides; (c) from about 20 to about 70% of water; (d) from about 10 to about 70% of one or more water-immiscible liquid compounds; and (e) from about 1 to about 55% of a surfactant component having a dispersing property. This invention also relates to a method for controlling an arthropod pest comprising diluting said suspension concentrate composition with water, optionally adding an adjuvant to form a diluted composition, and contacting the arthropod pest or its environment with an effective amount of said diluted composition.

  本发明涉及悬浮浓缩物组成物，其按总组成物重量计含有以下成分：(a)约0.1至约50%的一种或多种在室温下为固体的羧酰胺类节肢动物杀虫剂；(b)0至约50%的一种或多种除羧酰胺类节肢动物杀虫剂之外的生物活性剂；(c)约20至约70%的水；(d)约10至约70%的一种或多种不溶于水的液态化合物；以及(e)约1至约55%具有分散性质的表面活性剂成分。本发明还涉及一种控制节肢动物害虫的方法，包括将所述悬浮浓缩物组成物稀释于水中，可选地添加辅助剂以形成稀释后的组成物，并用所述稀释后的组成物与节肢动物害虫或其环境接触，以达到有效量的控制作用。
• Liquid Formulations of Carboxamide Arthropodicides
  申请人：Gutsche Oliver Walter

  公开号：US20080305093A1

  公开（公告）日：2008-12-11

  Disclosed are suspension concentrate compositions comprising by weight based on the total weight of the composition, about 0.1 to about 40% of at least one carboxamide arthropodicide; 0 to about 20% of at least one other biologically active agent; about 30 to about 95% of at least one water-immiscible liquid carrier; about 2 to about 50% of at least one emulsifier; about 0.01 to about 10% of a silica thickener; about 0.1 to about 10% of at least one protic solvent selected from water, a C 1 -C 12 alkanol and a C 2 -C 3 glycol; and about 0.001 to about 5% of at least one water-soluble carboxylic acid. This invention also relates to a method for controlling an arthropod pest comprising diluting said suspension concentrate composition with water, and optionally adding an adjuvant to form a diluted composition, and contacting the arthropod pest or its environment with an effective amount of said diluted composition.

  本发明涉及悬浮浓缩物组合物，其包括以下重量百分比，基于组合物的总重量：约0.1至约40％的至少一种羧酰胺类节肢动物杀虫剂；0至约20％的至少一种其他生物活性剂；约30至约95％的至少一种不溶于水的液体载体；约2至约50％的至少一种乳化剂；约0.01至约10％的二氧化硅增稠剂；约0.1至约10％的至少一种质子溶剂，所述质子溶剂选自水，C1-C12烷基醇和C2-C3二元醇；以及约0.001至约5％的至少一种水溶性羧酸。本发明还涉及一种控制节肢动物害虫的方法，包括将悬浮浓缩物组合物与水稀释，并可选地添加一种助剂以形成稀释后的组合物，并使用所述稀释后的组合物的有效量与节肢动物害虫或其环境接触。
• SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES
  申请人：Gutsche Oliver Walter

  公开号：US20110059846A1

  公开（公告）日：2011-03-10

  Disclosed is a solid arthropodicide composition comprising by weight (a) from 0.3 to 100% of a particulate component comprising particles of a solid carrier infiltrated with a mixture comprising (i) one or more carboxamide arthropodicides and (ii) a surfactant constituent; (b) from 0 to 50% of a surfactant component having dispersing and wetting properties; and (c) from 0 to 99.7% of one or more additional formulating ingredients. Also disclosed is a propagule contacted with a biologically effective amount of said composition.

  本发明公开了一种固体节肢动物杀虫剂组合物，其包括以下重量百分比的成分：（a）0.3至100％的颗粒组分，该颗粒组分包括被混合物浸渍的固体载体颗粒，所述混合物包括（i）一种或多种羧酰胺类节肢动物杀虫剂和（ii）一种表面活性剂成分；（b）具有分散和润湿性能的表面活性剂组分，其含量为0至50％；以及（c）0至99.7％的一种或多种额外的配方成分。本发明还公开了一种接触到所述组合物生物有效量的繁殖体。
• ANTHRANILAMIDE INSECTICIDES
  申请人：E.I. DUPONT DE NEMOURS AND COMPANY

  公开号：EP1812421A2

  公开（公告）日：2007-08-01
• METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS
  申请人：Annan Issac Billy

  公开号：US20090076092A1

  公开（公告）日：2009-03-19

  Disclosed is a method for disrupting reproductive performance of an adult arthropod pest comprising contacting the adult arthropod pest or its environment with a sub-lethal, reproduction-disruptive amount of a carboxamide arthropodicide, its N-oxide, or a salt thereof.