1,1-dimethylethyl 7-{[4-(acetylamino)-2-fluorophenyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate | 720692-99-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 1,1-dimethylethyl 7-{[4-(acetylamino)-2-fluorophenyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate
• 英文别名: tert-butyl 7-(4-acetamido-2-fluorophenoxy)-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylate
• CAS: 720692-99-9
• 化学式: C₂₃H₂₇FN₂O₄
• 分子量: 414.477
• InChiKey: KQKBFABTIZUAGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4-二氟硝基苯 在 palladium 10% on activated carbon 氢气 、 potassium carbonate 、 三乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 、 乙醇 、 二氯甲烷 为溶剂， 20.0~130.0 ℃ 、101.33 kPa 条件下， 反应 22.0h， 生成 1,1-dimethylethyl 7-{[4-(acetylamino)-2-fluorophenyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate
  参考文献：
  名称：

  [EN] BENZO ' D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  [FR] DERIVES BENZAZEPINE POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES

  摘要：

  本发明涉及公式（I）的苯并哌啶衍生物，其中：R1代表-C3-7环烷基，可选择地被C1-3烷基取代；具有药理活性，其制备方法，含有它们的组合物以及它们在治疗神经和精神疾病中的用途。

  公开号：

  WO2004056369A1

文献信息

• Benzo d!azepine derivatives for the treatment of neurological disorders
  申请人：Bamford James Mark

  公开号：US20060040918A1

  公开（公告）日：2006-02-23

  The present invention relates to benzazepine derivatives of formula (I) wherein: R 1 represents —C 3-7 cycloalkyl optionally substituted by C 1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及式（I）的苯并唑啉衍生物，其中：R1代表- C3-7 环烷基，可选择性地被C1-3烷基取代; 具有药理活性，其制备过程，含有它们的组合物以及它们在治疗神经和精神障碍中的用途。
• BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Bamford James Mark

  公开号：US20070299056A1

  公开（公告）日：2007-12-27

  The present invention relates to benzazepine derivatives of formula (I) wherein: R 1 represents —C 3-7 cycloalkyl optionally substituted by C 1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及式(I)的苯并氮杂环衍生物，其中：R1代表—C3-7环烷基，可选择性地被C1-3烷基取代；具有药理活性，其制备方法，含有它们的组合物以及它们在神经系统和精神障碍治疗中的应用。
• Benzazepine Derivatives For The Treatment of Neurological Disorders
  申请人：Bamford Mark James

  公开号：US20100145040A1

  公开（公告）日：2010-06-10

  The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型苯并氮杂环衍生物，其制备过程，含有它们的组合物以及它们在治疗神经系统和精神障碍方面的应用。
• Benzazepine derivatives for the treatment of neurological disorders
  申请人：Glaxo Group Limited

  公开号：US07799773B2

  公开（公告）日：2010-09-21

  The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型苯并氮杂环衍生物，其制备方法，包含它们的组合物，以及它们在治疗神经系统和精神障碍方面的用途。
• Novel benzazepine derivatives
  申请人：Glaxo Group Limited

  公开号：EP2133340A1

  公开（公告）日：2009-12-16

  The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders. More specifically, the invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein formula (I) is as defined herein.

  本发明涉及具有药理活性的新型苯并氮杂卓衍生物、其制备工艺、含有它们的组合物以及它们在治疗神经和精神疾病中的用途。 更具体地说，本发明涉及式（I）化合物或其药学上可接受的盐： 其中式 (I) 如本文所定义。