N-benzyl-N-cyclopropyl(4-methoxyphenyl)amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-cyclopropyl(4-methoxyphenyl)amine
• 英文别名: N-benzyl-N-cyclopropyl-4-methoxyaniline
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: ATSZWPRTVSLVIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.86
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.47
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  1-chlorocyclopropyl phenyl sulfoxide 、 N-lithio N-benzyl-p-anisidine 在 异丙基氯化镁 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 生成 N-benzyl-N-cyclopropyl(4-methoxyphenyl)amine
  参考文献：
  名称：

  Reaction of magnesium cyclopropylidene with N-lithio arylamines: a method for generation of α-amino-substituted cyclopropylmagnesiums and a study for their reactivity with electrophiles

  摘要：

  Magnesium cyclopropylidene was generated from 1-chlorocyclopropyl phenyl sulfoxide with i-PrMgCl in THF at -78 degrees C in high yield by a sulfoxide-magnesium exchange reaction. The generated magnesium cyclopropylidene was found to be reactive with N-lithio arylamines to give alpha-ammo-substituted cyclopropylmagnesiums. The reaction of the a-amino-substituted cyclopropylmagnesiums with several electrophiles was examined and a new method for a synthesis of cyclopropane amino acid derivatives was realized. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.080

文献信息

• Reaction of magnesium cyclopropylidene with N-lithio arylamines: a method for generation of α-amino-substituted cyclopropylmagnesiums and a study for their reactivity with electrophiles
  作者：Tsuyoshi Satoh、Mariko Miura、Ken Sakai、Yoshimi Yokoyama

  DOI：10.1016/j.tet.2006.01.080

  日期：2006.4

  Magnesium cyclopropylidene was generated from 1-chlorocyclopropyl phenyl sulfoxide with i-PrMgCl in THF at -78 degrees C in high yield by a sulfoxide-magnesium exchange reaction. The generated magnesium cyclopropylidene was found to be reactive with N-lithio arylamines to give alpha-ammo-substituted cyclopropylmagnesiums. The reaction of the a-amino-substituted cyclopropylmagnesiums with several electrophiles was examined and a new method for a synthesis of cyclopropane amino acid derivatives was realized. (c) 2006 Elsevier Ltd. All rights reserved.