Isobutyramide, N-(1,1,3,3-tetramethylbutyl)- | 6632-19-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Isobutyramide, N-(1,1,3,3-tetramethylbutyl)-
• 英文别名: 2-methyl-N-(2,4,4-trimethylpentan-2-yl)propanamide
• CAS: 6632-19-5
• 化学式: C₁₂H₂₅NO
• mdl: MFCD20355728
• 分子量: 199.337
• InChiKey: ZRWQTKBBQBIAHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.916
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  叔辛胺 、 异丁酰氯 生成 Isobutyramide, N-(1,1,3,3-tetramethylbutyl)-
  参考文献：
  名称：

  GB1476351

  摘要：

  公开号：

文献信息

• [EN] IMMUNOMODULATOR COMPOUNDS<br/>[FR] COMPOSÉS IMMUNOMODULATEURS
  申请人：CHEMOCENTRYX INC

  公开号：WO2019023575A1

  公开（公告）日：2019-01-31

  Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  提供了作为免疫调节剂有用的化合物。这些化合物具有以下的化学式（I），包括其立体异构体和药用盐，其中Z、L、R1a、R1b、R1c、R1d、R2a、R2b、R2c、R3、R4、R5、R6a、R6b、m和n的定义如本文所述。还公开了与这些化合物的制备和使用相关的方法，以及包含这些化合物的药物组合物。
• Pyrrolidine Compounds Which Modulate The CB2 Receptor
  申请人：Berry Angela

  公开号：US20120142677A1

  公开（公告）日：2012-06-07

  Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. (I)

  本发明揭示了调节CB2受体的化合物。本发明的化合物结合并激动CB2受体，并且可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。 (I)
• EP2738190B1
  申请人：——

  公开号：EP2738190B1

  公开（公告）日：2017-08-09
• EZH2 INHIBITORS AND USES THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20190135796A1

  公开（公告）日：2019-05-09

  The present disclosure provides compounds of any one of Formulae (I), (II), and (III). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1 (EZH1) and enhancer of zeste homolog 2 (EZH2)) and are useful in treating and/or preventing a broad range of diseases (e.g., proliferative diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
• US4136164A
  申请人：——

  公开号：US4136164A

  公开（公告）日：1979-01-23