2-<<2-(dimethylamino)ethyl>amino>nitrobenzene hydrochloride | 131637-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-<<2-(dimethylamino)ethyl>amino>nitrobenzene hydrochloride
• 英文别名: N-(2-nitrophenyl)-2-(dimethylamino)ethylamine hydrochloride；N,N-dimethyl-N'-(2-nitro-phenyl)-ethylenediamine; hydrochloride；N,N-Dimethyl-N'-(2-nitro-phenyl)-aethylendiamin; Hydrochlorid；N',N'-dimethyl-N-(2-nitrophenyl)ethane-1,2-diamine;hydrochloride
• CAS: 131637-63-3
• 化学式: C₁₀H₁₅N₃O₂*ClH
• 分子量: 245.709
• InChiKey: SJNCXOKQRAXWGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  61.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-<<2-(dimethylamino)ethyl>amino>nitrobenzene hydrochloride 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以7.5 g的产率得到N-(2-aminophenyl)-2-(dimethylamino)ethylamine hydrochloride
  参考文献：
  名称：

  Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor

  摘要：

  A series of [1,2,4]triazolo[4,3-alpha][1,4]benzodiazepines bearing an ethynyl functionality at the 8-position and the isosteric thieno[3,2-f][1,2,4]triazolo[4,3-alpha][1,4]diazepines were prepared and evaluated as antagonists of platelet activating factor. The effects of substitution were explored in in vitro and in vivo test systems designed to measured PAF-antagonistic activity. Results are discussed and compared with previously published data. Many of the compounds had activity superior to WEB 2086, compound 1. In general, the thieno analogues exhibited better oral activity than the corresponding benzodiazepines. The duration of activity upon oral administration was modulated by the substitution on the acetylenic side chain. Compounds 71 and 81 were selected for further pharmacological evaluation as a result of their good oral potency and exceptionally long duration of action.

  DOI：

  10.1021/jm00107a048
• 作为产物：
  描述：

  硝基氯苯 、 N,N-二甲基乙二胺 、 盐酸 生成 2-<<2-(dimethylamino)ethyl>amino>nitrobenzene hydrochloride
  参考文献：
  名称：

  LUMMA W. C. JR.; HARTMAN R. D.; SAARI W. S.; ENGELHARDT E. L.; LOTTI V. J+, J. MED. CHEM., 1981, 24, NO 1, 93-101

  摘要：

  DOI：

文献信息

• Piperazinylquinoxalines with central serotoninmimetic activity
  作者：William C. Lumma、Richard D. Hartman、Walfred S. Saari、Edward L. Engelhardt、Victor J. Lotti、Clement A. Stone

  DOI：10.1021/jm00133a019

  日期：1981.1

  Regioselective syntheses of substituted 2-chloroquinoxalines and derived 2-(1-piperazinyl)quinoxalines are described. Selectivity in regards to serotonin reuptake blocking and serotoninmimetic activities of the piperazinylquinoxalines is reported. In general, introduction of a 6-substituent into the piperazinylquinoxaline enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted and 3-hydroxypiperazinylquinoxalines had primarily serotoninmimetic activity.
• WALSER, ARMIN;FLYNN, THOMAS;MASON, CARL;CROWLEY, HERMAN;MARESCA, CATHERIN+, J. MED. CHEM., 34,(1991) N, C. 1209-1221
  作者：WALSER, ARMIN、FLYNN, THOMAS、MASON, CARL、CROWLEY, HERMAN、MARESCA, CATHERIN+

  DOI：——

  日期：——