环丁基三苯基鏻溴化物 | 3666-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 环丁基三苯基鏻溴化物
• 英文名称: cyclobutyl triphenylphosphonium bromide
• 英文别名: cyclobutyltriphenylphosphonium bromide；Cyclobutyltriphenylphosphoniumbromid；cyclobutyl-triphenyl-phosphonium; bromide；Cyclobutyl-triphenyl-phosphonium; Bromid；cyclobutyl triphenyl phosphonium bromide；Cyclobutyl-triphenylphosphoniumbromid；cyclobutyl(triphenyl)phosphanium;bromide
• CAS: 3666-89-5
• 化学式: Br*C₂₂H₂₂P
• 分子量: 397.294
• InChiKey: UFTAXONIWSZBTF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.54
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  环丁基三苯基鏻溴化物 在 sodium hydroxide 作用下， 生成 [环丁基(苯基)磷酰基]苯
  参考文献：
  名称：

  Reactions of phosphorus compounds. XVII. Reactions of cyclopropylmethyl- and certain C4-triphenylphosphonium salts

  摘要：

  DOI：

  10.1021/jo01272a014
• 作为产物：
  描述：

  三苯基膦 在 苯基锂 作用下， 生成 环丁基三苯基鏻溴化物
  参考文献：
  名称：

  Mondon, Justus Liebigs Annalen der Chemie, 1957, vol. 603, p. 115,127

  摘要：

  DOI：

文献信息

• [EN] VITAMIN D ANALOGUES, COMPOSITIONS COMPRISING SAID ANALOGUES AND THEIR USE<br/>[FR] ANALOGUES DE LA VITAMINE D, COMPOSITIONS COMPRENANT LESDITS ANALOGUES ET LEUR UTILISATION
  申请人：LEO PHARMA AS

  公开号：WO2004037781A1

  公开（公告）日：2004-05-06

  Compounds according to formula I: in which formula R1 and R2, which may be the same or different, represent halogen, (C1-C6) hydrocarbyl, optionally substituted with one or two hydroxyl group on one or more fluorine atoms, or, together with the carbon atom to which they are both attached, R1 and R2 form a (C3-C6)carbocyclic ring, or one of R1 and R2 taken together with R3 forms a direct bond, such that a triple bond is constituted, or R1 and R2 represent both hydrogen; R3 when not forming a direct bond with one of R1 and R2 represents hydrogen or (C1-C3)hydrocarbyl; X represents (E)-ethylene, (Z)-ethylene, ethynylene, or a bond; Y and Z independently represent hydrogen or methyl; the bond between C#16 and C#17 is depicted with a dotted line to illustrate that said bond may be either a single bond, in which case the projection of the ring substituents is beta, or a double bond; A represents hydroxyl, fluorine or hydrogen; B represents CH2 or H2; the configuration is the 3-position corresponds to the same configuration as in natural vitamine D3 (normal), or the configuration in the configuration in the 3-position is opposite to that of natural vitamin D3(epi); with the proviso that when X represents (E)-ethylene or (Z)-ethylene, one of R1 and R2 taken together with R3 may not form a direct bond, such that a triple bond is constituted; with the further proviso that when X represents a bond R1 ands R2 are nor hydrogen; with the further proviso that the compound of formula I is not 3(S)-hyroxy-9, 10-secocholesta-5(Z),7(E),10(19),22(E),24-penta-ene; and prodrugs and stereo isomeric forms thereof are provided together with their use in therapy, and their use in the manufacture of medicaments.

  根据公式I：其中公式中的R1和R2，可以相同也可以不同，代表卤素，(C1-C6)烃基，可选地在一个或多个氟原子上用一个或两个羟基取代，或者，与它们都连接的碳原子一起，R1和R2形成一个(C3-C6)碳环，或者R1和R2中的一个与R3一起形成直接键，从而构成三键，或者R1和R2都代表氢；当R3不与R1和R2中的一个形成直接键时，代表氢或(C1-C3)烃基；X代表(E)-乙烯，(Z)-乙烯，乙炔基，或者一个键；Y和Z独立地代表氢或甲基；C#16和C#17之间的键用虚线表示，以说明该键可以是单键，此时环取代基的投影为β，或者是双键；A代表羟基，氟或氢；B代表CH2或H2；3位的构型与天然维生素D3 (正常)中的构型相对应，或者3位的构型与天然维生素D3 (epi)中的构型相反；但是当X代表(E)-乙烯或(Z)-乙烯时，R1和R2中的一个与R3一起不能形成直接键，从而构成三键；进一步的条件是，当X代表一个键时，R1和R2不是氢；进一步的条件是，公式I的化合物不是3(S)-羟基-9,10-去甲胆骨化甾-5(Z),7(E),10(19),22(E),24-五烯；还提供了它们的前药和立体异构体形式，以及它们在治疗中的用途，以及它们在药物制造中的用途。
• Vinyl azides in heterocyclic synthesis. Part 5. Thermal and photochemical decomposition of azidocinnamates containing ortho-cycloalkylidene substituents
  作者：Christopher J. Moody、Graham J. Warrellow

  DOI：10.1039/p19870000913

  日期：——

  ortho-cycloalkylidene azidocinnamates (2b–e) in boiling toluene gives the indeno[1,2-b]tetrahydroazirines (8), derived by intramolecular ene reaction involving the CN bond of the intermediate 2H-azirines (11), as the major product. The intramolecular ene reaction is a highly favourable process, and also occurs at ca. 40 °C when the azirines (11) are formed by irradiation of the azides (2), although photochemical

  在沸腾的甲苯中加热邻-亚环烷基叠氮吲哚酸酯（2b - e），得到茚并[1,2- b ]四氢叠氮化物（8），其是通过分子内烯反应涉及中间体2 H-叠氮基的C N键（11）制得的，作为主要产品。分子内烯反应是非常有利的过程，并且也发生在约200℃ 。当通过叠氮化物（2）的辐照形成叠氮化物（11）时，温度为40°C），尽管叠氮基的光化学开环确实存在竞争。仅当通过环亚烷基双键的环氧化消除了这种分子内烯反应的可能性时，才能以任何程度形成亚乙烯基衍生的产物，环氧叠氮化物（7）以高收率得到4-取代的吲哚（14）。
• 1,2-Hydrogen migration and alkene formation in the photoexcited states of alkylphenyldiazomethanes
  作者：Sol Celebi、Soccoro Leyva、David A. Modarelli、Matthew S. Platz

  DOI：10.1021/ja00072a014

  日期：1993.9

  Laser flash photolysis of alkylphenyldiazomethanes in the presence of pyridine produces easily detected ylides. The data indicate that photolysis of alkylphenyldiazomethanes leads to both carbene formation and direct formation of rearrangement products which do not derive from relaxed carbene intermediates

  在吡啶存在下，烷基苯基重氮甲烷的激光闪光光解产生易于检测的叶立德。数据表明，烷基苯基重氮甲烷的光解导致卡宾的形成和重排产物的直接形成，这些产物不是来自松弛的卡宾中间体
• Reactions of bicyclobutylidene and 1,3-bis(trimethylene)propadiene
  作者：Lim Keow Bee、John W. Everett、Peter J. Garratt

  DOI：10.1016/0040-4020(77)80330-x

  日期：——

  A number of reactions of bicyclobutylidene (1) and 1,3-bis(trimethylene)propadiene (2), directed towards the preparation of compounds in which conjugated and steric effects of the cyclobutane ring could be evaluated, are described. Trispiro[3.0.3.0.2.0] undecane (4) was prepared from 1, and 1-cyclobutylidenespiro[3.2]hexane (8b) from 2. Thermolysis of 8b gave 9-methylenedispiro[3.0.3.1]nonane (14)

  描述了针对化合物的制备的联环丁烯（1）和1,3-双（三亚甲基）丙二烯（2）的许多反应，其中可以评估环丁烷环的共轭和空间效应。Trispiro [3.0.3.0.2.0]十一烷（4）从1制备，和1- cyclobutylidenespiro [3.2]己烷（8B从2.热分解）8b中，得到9- methylenedispiro [3.0.3.1]壬烷（14）。氧化1与单线态氧，得到“烯”产品17，并且经由bromohydroperoxide企图两步转化成二恶丁环19也给17。氧化2与过氧酸反应得到的产物可能来自氧化烯或双环氧乙烷。环丁烷环似乎没有提供任何空间保护以允许分离二氧杂环丁烷或氧化烯。描述了针对双环丁烯基的合成的三种不成功的路线（24），并且报道了双环丁烯-2,4'-二酮（39）和-2,2'-二酮（40）的合成。
• Liquid Crystal Compound Containing Cyclobutyl Group and Difluoromethyleneoxy Linking Group, and Preparation Method and Use Thereof
  申请人：ShijiaZhuang Chengzhi Yonghua Display Materials Co., Ltd.

  公开号：US20150284632A1

  公开（公告）日：2015-10-08

  A liquid crystal compound containing cyclobutyl and a linking group difluoromethyleneoxy, and a preparation method and use thereof are disclosed. The compound is as shown in Formula I. The liquid crystal compound containing cyclobutyl as a terminal group and difluoromethyleneoxy (—CF 2 O—) as a linking group in the molecular structure of Formula I according to the present invention, has not only a high dielectric anisotropy, but also importantly an extremely fast response speed and a high clearing point, which are of great significance for the formulation of a liquid crystal mixture.

  本发明公开了一种含有环丁基和连接基二氟甲氧基的液晶化合物，以及其制备方法和用途。该化合物如公式I所示。根据本发明，液晶化合物在分子结构中含有环丁基作为末端基和二氟甲氧基（-CF2O-）作为连接基，不仅具有高介电各向异性，而且非常快速的响应速度和高清晰点，这对于液晶混合物的配方具有重要意义。