Tert-butyl 4-[5,6-dichloro-1-[[4-(1,4-diazepan-1-ylmethyl)phenyl]methyl]benzimidazol-2-yl]piperidine-1-carboxylate | 614753-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Tert-butyl 4-[5,6-dichloro-1-[[4-(1,4-diazepan-1-ylmethyl)phenyl]methyl]benzimidazol-2-yl]piperidine-1-carboxylate
• 英文别名: tert-butyl 4-[5,6-dichloro-1-[[4-(1,4-diazepan-1-ylmethyl)phenyl]methyl]benzimidazol-2-yl]piperidine-1-carboxylate
• CAS: 614753-17-2
• 化学式: C₃₀H₃₉Cl₂N₅O₂
• 分子量: 572.578
• InChiKey: FCLXMUKGYFAUHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Tert-butyl 4-[5,6-dichloro-1-[[4-(1,4-diazepan-1-ylmethyl)phenyl]methyl]benzimidazol-2-yl]piperidine-1-carboxylate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.5h， 生成 5,6-Dichloro-1-[[4-(1,4-diazepan-1-ylmethyl)phenyl]methyl]-2-(4-piperidyl)benzimidazole
  参考文献：
  名称：

  2-Piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities

  摘要：

  A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles arc effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly entercococci, and represent a new class of potential antibacterial agents. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00661-9
• 作为产物：
  描述：

  4,5-二氯邻苯二胺 在 4-二甲氨基吡啶 、 sodium hydroxide 、 potassium carbonate 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 Tert-butyl 4-[5,6-dichloro-1-[[4-(1,4-diazepan-1-ylmethyl)phenyl]methyl]benzimidazol-2-yl]piperidine-1-carboxylate
  参考文献：
  名称：

  2-Piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities

  摘要：

  A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles arc effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly entercococci, and represent a new class of potential antibacterial agents. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00661-9

文献信息

• 2-Piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities
  作者：Yun He、Baogen Wu、Jun Yang、Dale Robinson、Lisa Risen、Ray Ranken、Lawrence Blyn、Suzie Sheng、Eric E Swayze

  DOI：10.1016/s0960-894x(03)00661-9

  日期：2003.10

  A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles arc effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly entercococci, and represent a new class of potential antibacterial agents. (C) 2003 Elsevier Ltd. All rights reserved.