ethyl thiosalicylate | 80282-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl thiosalicylate
• 英文别名: S-ethyl 2-hydroxybenzenecarbothioate
• CAS: 80282-50-4
• 化学式: C₉H₁₀O₂S
• 分子量: 182.243
• InChiKey: QUGBRUUSZSTZHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二氯双十二烷基锡烷 、 ethyl thiosalicylate 以 sodium hydroxide 为溶剂， 生成 dilauryltin bis-[2-(ethoxycarbonyl)phenyl-mercaptide]
  参考文献：
  名称：

  Organotin alkoxycarbonylphenyl mercaptides and the use thereof

  摘要：

  公式I的化合物##STR1##中，其中R为C.sub.8-C.sub.14烷基、苯基、C.sub.7-C.sub.9芳基烷基或R"OOC-CH.sub.2--CH.sub.2，R'为C.sub.2-C.sub.18烷基、C.sub.5-C.sub.12环烷基、苯基、C.sub.7-C.sub.30烷基芳基或C.sub.7-C.sub.18-芳基烷基，R"为C.sub.1-C.sub.14烷基、苯基或C.sub.7-C.sub.9芳基烷基，x为1或2，对含氯热塑性塑料，特别是对PVC，具有热稳定剂作用。

  公开号：

  US05021491A1
• 作为产物：
  描述：

  水杨酸 在 magnesium ethylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 ethyl thiosalicylate
  参考文献：
  名称：

  一种方便的一锅法，以镁离子为催化剂合成硫醇酯

  摘要：

  在催化量的Mg（OEt）2存在下，通过用硫醇处理1-酰基咪唑，可以高收率制备各种硫醇酯（R 1 COSR 2）。还可以通过用羰基-1,1'-二咪唑处理丙二酸单烷基丙二酸镁[R 1 OCOCH（R 3）COOMg12]，然后以高收率制备丙二酸半硫醇酯[R 1 OCOCH（R 3）COSR 2 ] 。硫醇。

  DOI：

  10.1016/s0040-4039(01)81874-8

文献信息

• Condensed imidazole derivatives
  申请人：Eisai Co., Ltd.

  公开号：US20040116328A1

  公开（公告）日：2004-06-17

  The present invention is related to compounds represented by the following formula, or salts or hydrates thereof 1 wherein, T 1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C 1-6 alkyl group which may have one or more substituents, or such; Z 1 and Z 2 each independently represent a nitrogen atom or a group represented by the formula —CR 2 —; R 1 and R 2 independently represent a hydrogen atom, a C 1-6 alkyl group which may have one or more substituents, or a C 1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.

  本发明涉及以下公式所代表的化合物，或其盐或水合物 其中， T 1 代表一个含有一个或两个氮原子的4-至12-成员杂环基团，在环中是单环或双环结构，可能具有一个或多个取代基; X代表一个C 1-6 烷基基团，可能具有一个或多个取代基，或类似物; Z 1 和Z 2 各自独立地代表一个氮原子或由公式—CR 2 —所代表的基团; R 1 和R 2 独立地代表氢原子，一个C 1-6 烷基基团，可能具有一个或多个取代基，或一个C 1-6 烷氧基基团，可能具有一个或多个取代基，或类似物。 这些是表现出优异DPPIV抑制活性的新颖化合物。
• Novel condensed imidazole derivatives
  申请人：Yoshikawa Seiji

  公开号：US20060100199A1

  公开（公告）日：2006-05-11

  The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T 1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C 1-6 alkyl group which may have one or more substituents, or such; Z 1 and Z 2 each independently represent a nitrogen atom or a group represented by the formula —CR 2 —; R 1 and R 2 independently represent a hydrogen atom, a C 1-6 alkyl group which may have one or more substituents, or a C 1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent

  本发明涉及以下式子所表示的化合物、盐或水合物：其中，T1代表一个含有一个或两个氮原子的4-至12元杂环基团，它是一个单环或双环结构，可能有一个或多个取代基；X代表一个C1-6烷基基团，它可能有一个或多个取代基，或者如此；Z1和Z2各自独立地代表一个氮原子或者由公式—CR2—所表示的基团；R1和R2各自独立地代表一个氢原子，一个C1-6烷基基团，它可能有一个或多个取代基，或者一个C1-6烷氧基基团，它可能有一个或多个取代基，或者如此。这些是新颖的化合物，具有优异的性能。
• CONDENSED IMIDAZOLE DERIVATIVES
  申请人：Yoshikawa Seiji

  公开号：US20090018331A1

  公开（公告）日：2009-01-15

  The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T 1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C 1-6 alkyl group which may have one or more substituents, or such; Z 1 and Z 2 each independently represent a nitrogen atom or a group represented by the formula —CR 2 —; R 1 and R 2 independently represent a hydrogen atom, a C 1-6 alkyl group which may have one or more substituents, or a C 1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.

  本发明涉及下式所示的化合物、盐或水合物： 其中， T1表示一个4-到12成员的杂环基团，在环中含有一个或两个氮原子，是单环或双环结构，可以有一个或多个取代基； X表示一个C1-6烷基基团，可以有一个或多个取代基； Z1和Z2各自独立地表示一个氮原子或由公式—CR2—表示的基团； R1和R2各自独立地表示氢原子、一个C1-6烷基基团，可以有一个或多个取代基，或一个C1-6烷氧基基团，可以有一个或多个取代基。 这些是具有出色的DPPIV抑制活性的新型化合物。
• PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF
  申请人：Agilent Technologies, Inc.

  公开号：US20150315227A1

  公开（公告）日：2015-11-05

  Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased resistance to depurination during polynucleotide synthesis. In some instances, the methods and compositions disclosed herein utilize a combination of the phosphorus and amidine nucleobase protecting groups in the synthesis of polynucleotides having a sequence of 200 or more monomeric units in length. Also provided are methods for synthesizing a polynucleotide (e.g., a DNA) using one or more compounds disclosed herein.

  本公开涉及的方面包括使用磷和/或核碱基保护基的组合物，这些组合物用于合成长的多核苷酸。提供了磷保护基，有助于增加逐步耦合产率和/或可以在氧化步骤中去除的磷保护基。提供了酰胺核碱基保护基，用于本主题的组合物和方法，例如在多核苷酸合成过程中提供了增加的去嘌呤作用的抵抗力。在某些情况下，本公开的方法和组合物利用磷和酰胺核碱基保护基的组合合成具有200个或更多单体单位长度序列的多核苷酸。还提供了使用本文所述的一种或多种化合物合成多核苷酸（例如DNA）的方法。
• NOVEL FUSED IMIDAZOLE DERIVATIVE
  申请人：Eisai Co., Ltd.

  公开号：EP1514552A1

  公开（公告）日：2005-03-16

  The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula -CR2-; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.

  本发明涉及下式所代表的化合物或其盐类或水合物 其中 T1 代表环中含有一个或两个氮原子的 4 至 12 元杂环基团，其为单环或双环结构，可具有一个或多个取代基； X 代表可带有一个或多个取代基的 C1-6 烷基，或此类； Z1和Z2各自独立地代表一个氮原子或一个由式-CR2-代表的基团； R1和R2各自独立地代表氢原子、C1-6烷基（可带有一个或多个取代基）或C1-6烷氧基（可带有一个或多个取代基）或此类基团。 这些新型化合物具有优异的 DPPIV 抑制活性。