2'-deoxycytidyl-(3'->5'){2'-deoxyguanosine-3'-[phosphoro-(2''-O-hydroxyethyl)quinoxaline]} | 148896-41-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （3'->5'）-二核苷酸和类似物
• 英文名称: 2'-deoxycytidyl-(3'->5'){2'-deoxyguanosine-3'-[phosphoro-(2''-O-hydroxyethyl)quinoxaline]}
• CAS: 148896-41-7
• 化学式: C₂₉H₃₄N₁₀O₁₃P₂
• 分子量: 792.596
• InChiKey: DZQBHDOCTLZLIK-ILWPDHKNSA-N

物化性质

• 密度：
  1.97±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  54.0
• 可旋转键数：
  14.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  326.49
• 氢给体数：
  6.0
• 氢受体数：
  20.0

反应信息

• 作为反应物：
  描述：

  2'-deoxycytidyl-(3'->5'){2'-deoxyguanosine-3'-[phosphoro-(2''-O-hydroxyethyl)quinoxaline]} 在 亚精胺 、 乙二胺四乙酸 、 polynucleotide kinase 、 <γ-32P>ATP 、 三羟甲基氨基甲烷盐酸盐 、 magnesium chloride 作用下， 反应 0.5h， 生成
  参考文献：
  名称：

  On the chemistry of RNA degradation by Fe·bleomycin

  摘要：

  The chemistry of RNA degradation by Fe bleomycin was studied using two RNA substrates that are modified efficiently at a small number of sites by the antitumor antibiotic. Cleavage of a tRNA(His) precursor transcript by Fe(II).BLM A(2) was shown to require O-2; cleavage was also observed when the same substrate was treated with Fe(III).BLM A(2) + H2O2. Consistent with earlier observations made for DNA, the extent of tRNA(His) precursor cleavage was greater for Fe(II).BLM A(5), than for Fe(II).BLM A(2); the least cleavage was obtained using Fe(II).BLM demethyl A(2). By the use of a P-32 end labeled tRNA precursor transcript that was also H-3 labeled within the uracil moieties, it was shown that release of uracil was nearly stoichiometric with tRNA strand scission by Fe(II).BLM A(2). Nonetheless, treatment of the tRNA(His) with hydrazine following BLM-mediated cleavage indicated formation of a new product that must have derived from a BLM-induced lesion. Also employed far characterization of BLM cleavage of RNA were the octanucleotides CGCTAGCG, C-3-ribo-CGCTAGCG and C-3-ara-CGCTAGCG. Analysis of the products of cleavage indicates that Fe . BLM is capable of mediating cleavage by abstraction of a H atom either from C-4'H or C-1'H of the chimeric oligonucleotides. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00038-2
• 作为产物：
  描述：

  5'-(4,4'-dimethoxytrityl)-N²-isobutyryl-2'-deoxyguanosine-3'-[H-phosphono-(2''-O-hydroxyethyl)quinoxaline] 在 吡啶 、 ammonium hydroxide 、 碘 、 溶剂黄146 、 三氟乙酸 、 三甲基乙酸 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 16.17h， 生成 2'-deoxycytidyl-(3'->5'){2'-deoxyguanosine-3'-[phosphoro-(2''-O-hydroxyethyl)quinoxaline]}
  参考文献：
  名称：

  On the chemistry of RNA degradation by Fe·bleomycin

  摘要：

  The chemistry of RNA degradation by Fe bleomycin was studied using two RNA substrates that are modified efficiently at a small number of sites by the antitumor antibiotic. Cleavage of a tRNA(His) precursor transcript by Fe(II).BLM A(2) was shown to require O-2; cleavage was also observed when the same substrate was treated with Fe(III).BLM A(2) + H2O2. Consistent with earlier observations made for DNA, the extent of tRNA(His) precursor cleavage was greater for Fe(II).BLM A(5), than for Fe(II).BLM A(2); the least cleavage was obtained using Fe(II).BLM demethyl A(2). By the use of a P-32 end labeled tRNA precursor transcript that was also H-3 labeled within the uracil moieties, it was shown that release of uracil was nearly stoichiometric with tRNA strand scission by Fe(II).BLM A(2). Nonetheless, treatment of the tRNA(His) with hydrazine following BLM-mediated cleavage indicated formation of a new product that must have derived from a BLM-induced lesion. Also employed far characterization of BLM cleavage of RNA were the octanucleotides CGCTAGCG, C-3-ribo-CGCTAGCG and C-3-ara-CGCTAGCG. Analysis of the products of cleavage indicates that Fe . BLM is capable of mediating cleavage by abstraction of a H atom either from C-4'H or C-1'H of the chimeric oligonucleotides. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00038-2