尿酸氧化酶

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （3'->5'）-二核苷酸和类似物
• 中文名称: 尿酸氧化酶
• 中文别名: 环拉酸；尿酸酶；尿酸氧化酶；尿酸酶(猪肝)；尿酸酶(牛肾)
• 英文名称: azanium;[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] phosphate
• 化学式: C18H26N5O14P
• 分子量: 567.4
• InChiKey: VPXDHZMLJOJKOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  258
• 氢给体数：
  7
• 氢受体数：
  14

ADMET

毒理性

• 在妊娠和哺乳期间的影响

母乳喂养期间使用总结：目前没有关于母乳喂养期间使用拉布立酶的临床信息。由于它是一种大分子蛋白质，分子量约为34,000 Da，母乳中的含量可能非常低，而且由于它可能被婴儿的胃肠道破坏，因此吸收的可能性不大。然而，制造商建议在拉布立酶治疗期间及最后一剂后的2周内停止母乳喂养。 ◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。 ◉ 对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。

◉ Summary of Use during Lactation:No information is available on the clinical use of rasburicase during breastfeeding. Because it is a large protein molecule with a molecular weight of about 34,000 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. However, the manufacturer recommends that breastfeeding be discontinued during rasburicase therapy and for 2 weeks after the final dose. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)

反应信息

• 作为反应物：
  描述：

  4-氨基安替比林 、 尿酸氧化酶 在 水 作用下， 以 磷酸肌酸 为溶剂， 反应 0.08h， 生成 尿酸
  参考文献：
  名称：

  Peroxidase catalyzed enzyme assay by sample PRG-treatment

  摘要：

  本发明公开了一种在含有还原物质的样品中测定分析物的方法。通过使用样品中不参与另一种酶促氧化还原反应的组分，通过酶促氧化还原反应生成的过氧化氢与还原物质反应分解还原物质后，再分解剩余的过氧化氢，然后将分析物进行酶促氧化还原反应形成过氧化氢，最终通过已知方法测定过氧化氢的含量。

  公开号：

  US05246836A1

文献信息

• Reagent and method for the analytic determination of hydrogen peroxide
  申请人：Millipore Corporation

  公开号：US04247631A1

  公开（公告）日：1981-01-27

  A 3-aminobenzoic acid or a 3-aminobenzenesulfonic acid, when reacted with a 4-aminoantipyrine in aqueous medium in the presence of hydrogen peroxide forms a novel colored dye which is believed to be a charge-transfer complex of free radicals formed from the 3-aminoaromatic acid and the 4-aminoantipyrine. The dye and the process by which it is produced are useful in analytical procedures for hydrogen peroxide, as well as in enzymatic analyses involving the formation of hydrogen peroxide.

  一种3-氨基苯甲酸或3-氨基苯磺酸，在水介质中与4-氨基安替比林在过氧化氢存在下反应，形成一种新的有色染料，该染料被认为是由3-氨基芳香酸和4-氨基安替比林形成的自由基的电荷转移复合物。该染料及其生产过程在氢过氧化物的分析程序以及涉及氢过氧化物形成的酶分析中是有用的。
• Determination of hydrogen peroxide
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：US04251629A1

  公开（公告）日：1981-02-17

  Colorimetrical determination of hydrogen peroxide in clinical examinations, food additives analyses and general analyses can be carried out accurately, rapidly and economically by using a composition for producing color producing reagents comprising 4-aminoantipyrine, a N-substituted-3-alkylaniline and a hydrogen peroxide activating agent such as peroxidase, said composition forming a coloring material having excellent sensitivity and color stability in contact with hydrogen peroxide.

  通过使用用于产生染色试剂的组合物，包括4-氨基苯甲酰肼，一种N-取代-3-烷基苯胺和一种过氧化氢活化剂（如过氧化物酶），可以准确、快速、经济地测定临床检查、食品添加剂分析和一般分析中的过氧化氢。该组合物与过氧化氢接触时形成具有良好灵敏度和颜色稳定性的染色材料。
• Clinical analytical system
  申请人：——

  公开号：US04264560A1

  公开（公告）日：1981-04-28

  An arrangement for chemical analysis of a small quantity of sample wherein a specimen of a small size is passed through a porous distribution first medium onto a reagent-containing second medium is disclosed. The reagent-containing second medium is a thin, flat, liquid-impervious medium. A reagent is encapsulated upon the second medium as a flat, liquid-phase surface. The first and second mediums are so arranged and disposed that when firmly pressed together, the encapsulated liquid reagent will be liberated and the specimen will be distributed through the first medium onto the liquid-phase liberated reagent where the subsequent reaction of the liquid-phase reagent and the specimen can then be identified by reading means.

  本发明公开了一种化学分析小样品的方法，其中将小尺寸的样品经过多孔分配第一介质传递到含有试剂的第二介质中。试剂含有的第二介质是一种薄的、平坦的、不透水的介质。试剂被封装在第二介质上，形成一个平坦的液相表面。第一和第二介质被安排和布置，当它们被紧密压在一起时，封装的液体试剂将被释放，样品将被分布到液相释放的试剂上，然后可以通过读取手段识别液相试剂和样品的后续反应。
• 4-Aminoantipyrine dye for the analytic determination of hydrogen peroxide
  申请人：Millipore Corporation

  公开号：US04321397A1

  公开（公告）日：1982-03-23

  A 3-aminobenzoic acid or a 3-aminobenzenesulfonic acid, when reacted with a 4-aminoantipyrine in aqueous medium in the presence of hydrogen peroxide forms a novel colored dye which is believed to be a charge-transfer complex of free radicals formed from the 3-aminoaromatic acid and the 4-aminoantipyrine. The dye and the process by which it is produced are useful in analytical procedures for hydrogen peroxide, as well as in enzymatic analyses involving the formation of hydrogen peroxide.

  当3-氨基苯甲酸或3-氨基苯磺酸在水介质中与4-氨基安替比林在过氧化氢存在下反应时，形成一种新的彩色染料，据信是由3-氨基芳香酸和4-氨基安替比林形成的自由基电荷转移复合物。该染料及其生产过程在氢过氧化物的分析程序以及涉及氢过氧化物形成的酶分析中是有用的。
• Peroxidase catalyzed enzyme assay by sample PRG-treatment
  申请人：Kyowa Medex Co., Ltd.

  公开号：US05246836A1

  公开（公告）日：1993-09-21

  A method for determination of an analyte in a sample containing reducing substances is disclosed. After the decomposition of the reducing substances by reaction with hydrogen peroxide formed by enzymatic Redox reaction using a component in the sample which does not participate in another enzymatic Redox reaction using the analyte, the remaining hydrogen peroxide is decomposed, and then the analyte is subjected to enzymatic Redox reaction to form hydrogen peroxide which is then determined by a known method.

  本发明公开了一种在含有还原物质的样品中测定分析物的方法。通过使用样品中不参与另一种酶促氧化还原反应的组分，通过酶促氧化还原反应生成的过氧化氢与还原物质反应分解还原物质后，再分解剩余的过氧化氢，然后将分析物进行酶促氧化还原反应形成过氧化氢，最终通过已知方法测定过氧化氢的含量。