ethyl 2-methyl-3-butanoate | 141527-58-4

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物
• 英文名称: ethyl 2-methyl-3-butanoate
• 英文别名: ethyl 2-methyl-3-(tris(trimethylsilyl)silyl)butanoate；ethyl (2R,3R)-2-methyl-3-tris(trimethylsilyl)silylbutanoate
• CAS: 141527-58-4
• 化学式: C₁₆H₄₀O₂Si₄
• 分子量: 376.834
• InChiKey: JQZPOYYSPHVBOD-LSDHHAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.27
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  惕各酸乙酯 、 三(三甲基硅基)硅烷 在 偶氮二异丁腈 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 ethyl 2-methyl-3-butanoate 、 ethyl 2-methyl-3-butanoate
  参考文献：
  名称：

  Tris(trimethylsilyl)silane: an efficient hydrosilylating agent of alkenes and alkynes

  摘要：

  Tris(trimethylsilyl)silane adds across the double bond of a variety of mono-, di-, and trisubstituted olefins under free-radical conditions in good yields. The reaction, which proceeds via a free-radical chain mechanism, is highly regioselective (anti-Markovnikov). Addition to prochiral olefins bearing an ester group is highly stereoselective. The factors that control the stereochemistry have been discussed terms of preferred conformations of the intermediate carbon-centered radicals and are thought to be of steric origin.

  DOI：

  10.1021/jo00040a048

文献信息

• Tris(trimethylsilyl)silane: an efficient hydrosilylating agent of alkenes and alkynes
  作者：B. Kopping、C. Chatgilialoglu、M. Zehnder、B. Giese

  DOI：10.1021/jo00040a048

  日期：1992.7

  Tris(trimethylsilyl)silane adds across the double bond of a variety of mono-, di-, and trisubstituted olefins under free-radical conditions in good yields. The reaction, which proceeds via a free-radical chain mechanism, is highly regioselective (anti-Markovnikov). Addition to prochiral olefins bearing an ester group is highly stereoselective. The factors that control the stereochemistry have been discussed terms of preferred conformations of the intermediate carbon-centered radicals and are thought to be of steric origin.