diethylaminoethylthiuronium dihydrochloride | 5445-68-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 异硫脲类
• 英文名称: diethylaminoethylthiuronium dihydrochloride
• 英文别名: S-(2-diethylamino-ethyl)-isothiourea; dihydrochloride；S-(2-Diaethylamino-aethyl)-isothioharnstoff; Dihydrochlorid；Pseudourea, 2-(2-diethylaminoethyl)-2-thio-, hydrochloride；[amino-[2-(diethylamino)ethylsulfanyl]methylidene]azanium;chloride
• CAS: 5445-68-1
• 化学式: C₇H₁₉N₃S*2Cl
• 分子量: 248.22
• InChiKey: HQPKXVDUSOJXEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.38
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diethylaminoethylthiuronium dihydrochloride 在 sodium hydroxide 、 氯化亚砜 、 氯仿 作用下， 生成 2-(diethylamino)ethyl 2-chloropropyl sulfide
  参考文献：
  名称：

  Sulfur-containing Amines. IV¹

  摘要：

  DOI：

  10.1021/ja01195a015
• 作为产物：
  描述：

  2-二乙氨基氯乙烷盐酸盐 、 硫脲 在 乙醇 作用下， 生成 diethylaminoethylthiuronium dihydrochloride
  参考文献：
  名称：

  P REHOSPITAL U SE OF C ONTINUOUS P OSITIVE A IRWAY P RESSURE (CPAP) FOR P RESUMED P ULMONARY E DEMA : A P RELIMINARY C ASE S ERIES

  摘要：

  Objective: To describe the prehospital use of a continuous positive airway pressure (CPAP) system for the treatment of acute respiratory failure presumed to be due to cardiogenic pulmonary edema. Methods: Prospective case-series analysis. Paramedics administered CPAP via face mask at 10 cm H2O to patients believed to be in cardiogenic pulmonary edema and in imminent need of endotracheal intubation (ETI). Data from run sheets and hospital records were analyzed for treatment intervals, vital signs, complications, admitting diagnoses, need for ETI, and mortality. Results: Nineteen patients received prehospital CPAP therapy. Mean duration of therapy was 15.5 minutes. Pre- and post-therapy pulse oximetry was available for 15 patients and demonstrated an increase from a mean of 83.3% to a mean of 95.4%. None of the patients were intubated in the field. Two patients who did not tolerate the CPAP mask required ETI upon arrival in the emergency department (ED); an additional five patients required ETI within 24 hours. There was one death in the series and two additional adverse events (one aspiration pneumonia, one pneumothorax); none of these were attributable to the use of CPAP. The diagnosis of cardiogenic pulmonary edema was corroborated by the ED or in-hospital physician in 13 patients (68%). Paramedics reported no technical difficulties with the CPAP system. Conclusion: For patients with acute respiratory failure and presumed pulmonary edema, the prehospital use of CPAP is feasible and may avert the need for ETI. Future controlled studies are needed to assess the utility and cost-effectiveness of prehospital CPAP systems.

  DOI：

  10.1080/10903120190940119

文献信息

• 一类嘧啶衍生物及其制备抗肿瘤药物的应用
  申请人：陕西师范大学

  公开号：CN113956240B

  公开（公告）日：2023-02-14

  本发明公开了一类嘧啶衍生物及其制备抗肿瘤药物的应用，该衍生物的结构通式为：式中R为二乙氨基、吡咯烷基、4‑甲基哌嗪基等中任意一种；X1为氮、硫或氧原子；X2为氢、氟、氯、溴原子或甲氧基。本发明公开的嘧啶衍生物对人皮肤鳞状癌A431细胞、人结肠癌SW480细胞、人非小细胞肺癌A549细胞和人肺癌NCI‑H1975细胞的增殖均具有明显的抑制作用，可用于制备抗肿瘤药物。
• Vinyl Sulfides. II. Aminoalkyl Vinyl Sulfides
  作者：H. J. SCHNEIDER、J. J. BAGNELL、G. C. MURDOCH

  DOI：10.1021/jo01065a072

  日期：1961.6
• Mndshojan; Arojan, Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1959, vol. 12, p. 63,69
  作者：Mndshojan、Arojan

  DOI：——

  日期：——
• Sibirskaya, V. V.; Vorob'ev-Desyatovskii, N. V.; Kukushkin, Yu. N., Russian Journal of Inorganic Chemistry, 1980, vol. 25, p. 1374 - 1376
  作者：Sibirskaya, V. V.、Vorob'ev-Desyatovskii, N. V.、Kukushkin, Yu. N.、Postnikova, E. S.

  DOI：——

  日期：——
• Mndshojan; Kaldrikjan, Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1959, vol. 12, p. 55
  作者：Mndshojan、Kaldrikjan

  DOI：——

  日期：——