硫代氨基亚胺酸乙酯单(磷酸二乙酯)盐 | 21704-46-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 异硫脲类
• 中文名称: 硫代氨基亚胺酸乙酯单(磷酸二乙酯)盐
• 中文别名: S-乙基硫脲磷酸二乙酯
• 英文名称: S-ethylisothiouronium diethylphosphate
• 英文别名: [Amino(ethylsulfanyl)methylidene]azanium;diethyl phosphate
• CAS: 21704-46-1
• 化学式: C₃H₈N₂S*C₄H₁₁O₄P
• 分子量: 258.279
• InChiKey: CSYSULGPHGCBQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Pharmaceutical compositions for headache, migraine, nausea and emesis
  申请人：MEDITOR PHARMACEUTICALS LTD.

  公开号：US20040006044A1

  公开（公告）日：2004-01-08

  S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

  S-烷基硫代氨基膦酸二乙酯盐等类似物被用于治疗头痛，特别是偏头痛，以及预防或治疗恶心和呕吐。本发明的组合物还有效预防或缓解与偏头痛或其他医疗状况如化疗或放疗相关的呕吐，以及偏头痛的其他症状，包括畏声症和畏光症。
• AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
  申请人：LICHTER Jay

  公开号：US20090306225A1

  公开（公告）日：2009-12-10

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或耳压调节剂组合物和配方直接应用于耳媒介和/或耳内靶区，或通过灌注进入耳媒介和/或耳内结构，局部给患有耳部疾病的个体进行治疗。
• Auris Formulations for Treating Otic Diseases and Conditions
  申请人：Otonomy, Inc.

  公开号：US20160228357A1

  公开（公告）日：2016-08-11

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文介绍了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过直接将免疫调节剂和/或耳压调节剂组合物和配方局部应用于患有耳部疾病的个体的耳媒体和/或耳内靶区，或通过灌注到耳媒体和/或耳内结构中。
• Auris formulations for treating otic diseases and conditions
  申请人：Otonomy, Inc.

  公开号：US10272034B2

  公开（公告）日：2019-04-30

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或免疫调节压力调节剂组合物和制剂直接施用到耳道介质和/或耳道间质目标区域，或通过灌注到耳道介质和/或耳道间质结构中，对耳道疾病患者进行局部给药。
• Triglyceride otic formulations and uses thereof
  申请人：Otonomy, Inc.

  公开号：US10821185B2

  公开（公告）日：2020-11-03

  Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.

  本文公开了用于治疗耳部疾病和病症的甘油三酯制剂、组合物和方法。 此类甘油三酯制剂和组合物源自中链甘油三酯，可向外耳、中耳和/或内耳输送多种治疗剂。