(2-Bromomethyl-1-methyl-cyclopropyl)-benzene | 762273-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Bromomethyl-1-methyl-cyclopropyl)-benzene
• 英文别名: [2-(Bromomethyl)-1-methylcyclopropyl]benzene；[2-(bromomethyl)-1-methylcyclopropyl]benzene
• CAS: 762273-26-7
• 化学式: C₁₁H₁₃Br
• 分子量: 225.128
• InChiKey: CVDWDXUSTOICIT-UHFFFAOYSA-N

物化性质

• 沸点：
  267.6±9.0 °C(Predicted)
• 密度：
  1.323±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (2-Bromomethyl-1-methyl-cyclopropyl)-benzene 在 sodium azide 作用下， 以47%的产率得到(2-Azidomethyl-1-methyl-cyclopropyl)-benzene
  参考文献：
  名称：

  Access to functionalized cyclopropylcarbinyl compounds from homoallylic ethers via zirconocene intermediates

  摘要：

  Cyclopropylcarbinylzirconium complexes were generated from homoallylic ethers and zirconocene (CP2ZrCl2/2n-BuLi). They underwent further in situ transformations that is, bromination-substitution, transmetallation-functionalization and insertion reactions to afford various cyclopropylcarbinyl derivatives. In contrast, ring-opening products could be selectively obtained by treating the zirconium complex with MeLi, prior to functionalization. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.06.122
• 作为产物：
  描述：

  1-(2-甲氧基戊-4-烯-2-基)苯 在 正丁基锂 、 二氯二茂锆 、 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 为溶剂， 生成 (2-Bromomethyl-1-methyl-cyclopropyl)-benzene
  参考文献：
  名称：

  Access to functionalized cyclopropylcarbinyl compounds from homoallylic ethers via zirconocene intermediates

  摘要：

  Cyclopropylcarbinylzirconium complexes were generated from homoallylic ethers and zirconocene (CP2ZrCl2/2n-BuLi). They underwent further in situ transformations that is, bromination-substitution, transmetallation-functionalization and insertion reactions to afford various cyclopropylcarbinyl derivatives. In contrast, ring-opening products could be selectively obtained by treating the zirconium complex with MeLi, prior to functionalization. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.06.122

文献信息

• Access to functionalized cyclopropylcarbinyl compounds from homoallylic ethers via zirconocene intermediates
  作者：Jean-Luc Vasse、Jan Szymoniak

  DOI：10.1016/j.tetlet.2004.06.122

  日期：2004.8

  Cyclopropylcarbinylzirconium complexes were generated from homoallylic ethers and zirconocene (CP2ZrCl2/2n-BuLi). They underwent further in situ transformations that is, bromination-substitution, transmetallation-functionalization and insertion reactions to afford various cyclopropylcarbinyl derivatives. In contrast, ring-opening products could be selectively obtained by treating the zirconium complex with MeLi, prior to functionalization. (C) 2004 Elsevier Ltd. All rights reserved.