6-Iod-2'-desoxy-uridin | 889872-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Iod-2'-desoxy-uridin
• 英文别名: 6-Iododeoxyuridine；1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-iodopyrimidine-2,4-dione
• CAS: 889872-67-7
• 化学式: C₉H₁₁IN₂O₅
• 分子量: 354.101
• InChiKey: RLBBASVCQAPPMF-CPDSJTNBSA-N

物化性质

• 密度：
  2.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-Iod-2'-desoxy-uridin 、 1-芘硼酸 在 四(三苯基膦)钯 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 20.0h， 以79%的产率得到5-(1-pyrenyl)-2'-deoxyuridine
  参考文献：
  名称：

  Electron Injection into DNA: Synthesis and Spectroscopic Properties of Pyrenyl-Modified Oligonucleotides

  摘要：

  The nucleoside 5-(1-pyrenyl)-2'-deoxyuridine (1) was prepared by a Suzuki-Miyaura cross-coupling reaction and subsequently used as a DNA building block in order to prepare a range of modified oligonucleotides using phosphoramidite chemistry. The DNA duplexes contain a pyrenyl group covalently attached to the nucleobase uracil. Upon excitation at 340 nm an intramolecular electron transfer from the pyrenyl group to the uracil moiety takes place which represents an injection of an excess electron into the DNA base stack. Based on the results obtained by steady-state fluorescence and time-resolved pump-probe laser spectroscopy it was possible to show that base-to-base electron transfer can occur from the Py-dU group only to adjacent thymines.

  DOI：

  10.1002/1521-3765(20021104)8:21<4877::aid-chem4877>3.0.co;2-p

文献信息

• Pyrimidine Derivatives As Anticancer Agents
  申请人：Kotra Lakshmi P.

  公开号：US20100056468A1

  公开（公告）日：2010-03-04

  The present invention includes methods of treating or preventing cancer by administering an effective amount of 6-substituted pyrimidine derivatives of the Formula I to a subject need thereof:

  本发明涉及通过向需要该治疗的受体施用公式I的6-取代嘧啶衍生物的有效量来治疗或预防癌症的方法：
• [EN] PYRIMIDINE DERIVATIVES AS ANTICANCER AGENTS<br/>[FR] DÉRIVÉS DE PYRIMIDINE COMME AGENTS ANTI-CANCER
  申请人：UNIV HEALTH NETWORK

  公开号：WO2008083465A1

  公开（公告）日：2008-07-17

  [EN] The present invention includes methods of treating or preventing cancer by administering an effective amount of 6-substituted pyrimidine derivatives of the Formula I to a subject need thereof:
  [FR] La présente invention comprend des procédés de traitement ou de prévention du cancer par administration d'une quantité efficace de dérivés de pyrimidine substitués en position 6, représentés par la Formule I, chez un sujet en ayant besoin.