2,2':6',2''-Terpyridine-4'-acetic acid | 1228700-25-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,2':6',2''-Terpyridine-4'-acetic acid
• 英文别名: 2-(2,6-dipyridin-2-ylpyridin-4-yl)acetic acid
• CAS: 1228700-25-1
• 化学式: C₁₇H₁₃N₃O₂
• 分子量: 291.309
• InChiKey: LNUNVIXGIDOXQR-UHFFFAOYSA-N

物化性质

• 沸点：
  505.2±45.0 °C(Predicted)
• 密度：
  1.282±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  76
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2':6',2''-Terpyridine-4'-acetic acid 、 tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 48.25h， 以75%的产率得到Fmoc-aeg(tpy)-OtBu
  参考文献：
  名称：

  Cu^II Cross-Linked Antiparallel Dipeptide Duplexes Using Heterofunctional Ligand-Substituted Aminoethylglycine

  摘要：

  Two artificial dipeptides containing both a pendant monodentate (pyridine (py)) and tridentate (terpyridine (tpy) or phenyl terpyridine (phi-tpy)) ligand on an aminoethylglycine (aeg) backbone have been synthesized. These oligopeptides are fully characterized by one and two-dimensional NMR spectroscopy, mass spectrometry, and elemental analysis. The ligands were chosen because they coordinate Cu2+ to form [Cu(py)(tpy)](2+) complexes; when bound to the dipeptide scaffold, Cu2+ chelation cross-links the strands to form double-stranded duplex structures with an antiparallel arrangement. Using spectrophotometric titrations, we observe coordination of one Cu2+ metal per dipeptide strand. Mass spectrometry, NMR spectroscopy, vapor pressure osmometry, and HPLC confirm that the resulting structures are the dipeptide duplex cross-linked by two metal centers.

  DOI：

  10.1021/ic100252g
• 作为产物：
  描述：

  二氧化碳 、 甲基锂 、 4'-甲基-2,2':6',2''-三联吡啶 在 2,2,6,6-四甲基哌啶 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以40%的产率得到2,2':6',2''-Terpyridine-4'-acetic acid
  参考文献：
  名称：

  Cu^II Cross-Linked Antiparallel Dipeptide Duplexes Using Heterofunctional Ligand-Substituted Aminoethylglycine

  摘要：

  Two artificial dipeptides containing both a pendant monodentate (pyridine (py)) and tridentate (terpyridine (tpy) or phenyl terpyridine (phi-tpy)) ligand on an aminoethylglycine (aeg) backbone have been synthesized. These oligopeptides are fully characterized by one and two-dimensional NMR spectroscopy, mass spectrometry, and elemental analysis. The ligands were chosen because they coordinate Cu2+ to form [Cu(py)(tpy)](2+) complexes; when bound to the dipeptide scaffold, Cu2+ chelation cross-links the strands to form double-stranded duplex structures with an antiparallel arrangement. Using spectrophotometric titrations, we observe coordination of one Cu2+ metal per dipeptide strand. Mass spectrometry, NMR spectroscopy, vapor pressure osmometry, and HPLC confirm that the resulting structures are the dipeptide duplex cross-linked by two metal centers.

  DOI：

  10.1021/ic100252g

文献信息

• RAPID METHOD FOR MEASURING CYTOTOXICITY IN NON-RI SYSTEM
  申请人：Nagasaki University

  公开号：EP3127899A1

  公开（公告）日：2017-02-08

  The present invention aims to provide a novel compound for measuring cellular cytotoxicity or cell proliferation capacity accurately with high reproducibility, conveniently and rapidly, and a measurement method of cellular cytotoxicity or cell proliferation capacity by using the compound. The present invention relates to a compound represented by the formula (I): wherein R1 is a substituent, R2 and R3 are each an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, Y is a substituent, n is an integer of 0 - 3, Z is a single bond, -O-, -S-, -SO-, -SO2-, or -NR4- (R4 is a hydrogen atom or a substituent), and A is an optionally substituted C1-6 alkylene group) or a salt thereof.

  本发明旨在提供一种新型化合物，用于准确、重现性高、方便快捷地测量细胞毒性或细胞增殖能力，以及利用该化合物测量细胞毒性或细胞增殖能力的方法。本发明涉及一种由式（I）表示的化合物： 其中 R1 是取代基，R2 和 R3 分别是任选取代的烃基或任选取代的杂环基，Y 是取代基，n 是 0 - 3 的整数，Z 是单键、-O-、-S-、-SO-、-SO2- 或 -NR4- （R4 是氢原子或取代基），A 是任选取代的 C1-6 亚烷基）或其盐。
• Electrochemical sensors with a chemically attached molecular redox buffer
  申请人：Regents of the University of Minnesota

  公开号：US20180024087A1

  公开（公告）日：2018-01-25

  Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.
• Cu^II Cross-Linked Antiparallel Dipeptide Duplexes Using Heterofunctional Ligand-Substituted Aminoethylglycine
  作者：Matthew B. Coppock、Matthew T. Kapelewski、Hye Won Youm、Lauren A. Levine、James R. Miller、Carl P. Myers、Mary Elizabeth Williams

  DOI：10.1021/ic100252g

  日期：2010.6.7

  Two artificial dipeptides containing both a pendant monodentate (pyridine (py)) and tridentate (terpyridine (tpy) or phenyl terpyridine (phi-tpy)) ligand on an aminoethylglycine (aeg) backbone have been synthesized. These oligopeptides are fully characterized by one and two-dimensional NMR spectroscopy, mass spectrometry, and elemental analysis. The ligands were chosen because they coordinate Cu2+ to form [Cu(py)(tpy)](2+) complexes; when bound to the dipeptide scaffold, Cu2+ chelation cross-links the strands to form double-stranded duplex structures with an antiparallel arrangement. Using spectrophotometric titrations, we observe coordination of one Cu2+ metal per dipeptide strand. Mass spectrometry, NMR spectroscopy, vapor pressure osmometry, and HPLC confirm that the resulting structures are the dipeptide duplex cross-linked by two metal centers.