3-isopropyl-2-aminothiophenol | 1009797-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-isopropyl-2-aminothiophenol
• 英文别名: 2-Amino-3-isopropylbenzenethiol；2-amino-3-propan-2-ylbenzenethiol
• CAS: 1009797-92-5
• 化学式: C₉H₁₃NS
• 分子量: 167.275
• InChiKey: CQLNRYKXOCNRPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-isopropyl-2-aminothiophenol 、 2,6-二硝基氯苯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以38%的产率得到1-nitro-9-propan-2-yl-10H-phenothiazine
  参考文献：
  名称：

  一些新型吩噻嗪及其砜类和呋喃核糖苷的合成及生物活性

  摘要：

  本通讯描述了通过 Smiles 重排使 2-氨基苯硫醇 1 和邻卤硝基苯 2 反应合成取代的 10H-吩噻嗪。这些合成的吩噻嗪用作基础，通过用糖处理制备呋喃核苷。β-D-ribofuranosyl-1-acetate-2,3,5-tribenzoate。砜也可以通过在冰醋酸中用 H2O2 回流氧化 10H-吩噻嗪来合成。所有合成的化合物均已通过 IR、1 H NMR、13 C NMR 质谱和元素分析进行​​表征，并筛选了抗氧化和抗微生物活性。

  DOI：

  10.1080/10426500701544557

文献信息

• Synthesis and Antimicrobial Activities of Novel Biologically Active Heterocycles: 10H-Phenothiazines, Their Ribofuranosides, and Sulfone Derivatives
  作者：Yogesh Dixit、Rahul Dixit、Naveen Gautam、D. C. Gautam

  DOI：10.1080/15257770903362206

  日期：2009.12.7

  This article deals with the synthesis and antimicrobial activity of a series of novel substituted 10H-phenothiazines, their ribofuranosides, and sulfone derivatives. 10H-Phenothiazines were prepared by Smiles rearrangement. These prepared phenothiazines were used as the base to prepare ribofuranosides by treatment with sugar (1-O-acetyl-2,3,5-tri-O-benzoylribofuranose). Sulfone derivatives were prepared

  本文讨论了一系列新型取代的10H-吩噻嗪，它们的呋喃核糖苷和砜衍生物的合成和抑菌活性。通过Smiles重排制备10 H-吩噻嗪。这些制备的吩噻嗪用作碱，通过用糖（1-O-乙酰基-2,3,5-三-O-苯甲酰基核呋喃糖）处理来制备呋喃核糖苷。通过氧化10H-吩噻嗪制备砜衍生物。通过元素分析和光谱数据确定了合成化合物的结构。
• AROMATIC DIAMINE, AN INTERMEDIATE THEREFOR, A METHOD FOR PRODUCING THE AROMATIC DIAMINE, AND A METHOD FOR PRODUCING THE INTERMEDIATE THEREFOR
  申请人：SEIKA CORPORATION

  公开号：US20180079732A1

  公开（公告）日：2018-03-22

  A novel asymmetric diamine, diamino-2-(benzothiazole-2-yl)diphenyl ether, derivatives therefor, and an intermediate for the compound such as aminonitro-2-(benzothiazole-2-yl)diphenyl ether, dinitro-2-(benzothiazole-2-yl)diphenyl ether, and derivatives from these. Additionally, another novel asymmetric diamine, diamino-2-(benzoxazole-2-yl)diphenyl ether, derivatives therefor, and intermediate for the compound such as aminonitro-2-(benzoxazole-2-yl)diphenyl ether, dinitro-2-(benzoxazole-2-yl)diphenyl ether, and derivatives from these, and methods for preparing them.

  一种新型的不对称二胺，二氨基-2-(苯并噻唑-2-基)二苯醚，以及其衍生物，以及该化合物的中间体，如氨基硝基-2-(苯并噻唑-2-基)二苯醚，二硝基-2-(苯并噻唑-2-基)二苯醚，以及从中得到的衍生物。此外，另一种新型的不对称二胺，二氨基-2-(苯并噁唑-2-基)二苯醚，以及其衍生物，以及该化合物的中间体，如氨基硝基-2-(苯并噁唑-2-基)二苯醚，二硝基-2-(苯并噁唑-2-基)二苯醚，以及从中得到的衍生物，以及其制备方法。
• An Efficient Synthesis and Antimicrobial Studies of Bioactive 4H-1,4-Benzothiazine and Their Sulfone Derivatives
  作者：Naveen Gautam、Yogesh Dixit、Rahul Dixit、Sudesh Kumar Gupta、Dinesh Chand Gautam

  DOI：10.1080/10426507.2012.740703

  日期：2013.8.1

  4H-1,4-benzothiazines were prepared by condensation followed by oxidative cyclization of substituted 2-aminobenzenethiols with -diketones in dimethylsulfoxide. On refluxing with 30% hydrogen peroxide in glacial acetic acid, 4H-1,4-benzothiazines yielded 4H-1,4-benzothiazine-1,1-dioxides. Structural evaluation has been done by spectral and elemental analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activity and all these have shown moderate to high activity against the test microbes. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text, figures and tables.
• US9957241B2
  申请人：——

  公开号：US9957241B2

  公开（公告）日：2018-05-01
• Synthesis and Biological Activities of Some New Phenothiazines, Their Sulfones, and Ribofuranosides
  作者：Rahul Dixit、Yogesh Dixit、D. C. Gautam、Naveen Gautam

  DOI：10.1080/10426500701544557

  日期：2007.12.24

  communication describes the synthesis of substituted 10H-phenothiazines by reaction of 2-aminobenzenethiol 1 and o-halonitrobenzene 2 via Smiles rearrangement. These synthesized phenothiazines are used as base to prepare ribofuranosides by treatment with sugar viz. β -D-ribofuranosyl-1-acetate-2,3,5-tribenzoate. Sulfones are also synthesized by oxidation of 10H-phenothiazines refluxing with H2O2 in glacial

  本通讯描述了通过 Smiles 重排使 2-氨基苯硫醇 1 和邻卤硝基苯 2 反应合成取代的 10H-吩噻嗪。这些合成的吩噻嗪用作基础，通过用糖处理制备呋喃核苷。β-D-ribofuranosyl-1-acetate-2,3,5-tribenzoate。砜也可以通过在冰醋酸中用 H2O2 回流氧化 10H-吩噻嗪来合成。所有合成的化合物均已通过 IR、1 H NMR、13 C NMR 质谱和元素分析进行​​表征，并筛选了抗氧化和抗微生物活性。