3,5-二氯-2-甲基-苯甲酸 | 101567-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二氯-2-甲基-苯甲酸
• 英文名称: 3,5-dichloro-2-methyl-benzoic acid
• 英文别名: 3,5-Dichlor-2-methyl-benzoesaeure；3.5-Dichlor-o-toluylsaeure；3,5-Dichloro-2-methylbenzoic acid
• CAS: 101567-48-0
• 化学式: C₈H₆Cl₂O₂
• 分子量: 205.04
• InChiKey: MHJGSEXAJKXRKK-UHFFFAOYSA-N

物化性质

• 熔点：
  183.5-184.5 °C
• 沸点：
  320.4±37.0 °C(Predicted)
• 密度：
  1.442±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-二氯-2-甲基-苯甲酸 在 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 作用下， 以 四氯化碳 、 丙酮 为溶剂， 生成 Benzoic acid, 2-(bromomethyl)-3,5-dichloro-, methyl ester
  参考文献：
  名称：

  Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors

  摘要：

  Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active cathepsin D inhibitor was identified by high throughput screening. Subsequent optimization led to the discovery of a new class of small molecule inhibitors of this enzyme, culminating with the sulfonamide 13 (IC50 = 250 nM), (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00433-3
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 、 溶剂黄146 作用下， 生成 3,5-二氯-2-甲基-苯甲酸
  参考文献：
  名称：

  Vegetation mapping of a tropical freshwater swamp in the Northern Territory, Australia: A comparison of aerial photography, Landsat TM and SPOT satellite imagery

  摘要：

  The tropical wetland environments of northern Australia have ecological, social, cultural and economic values. Additionally, these areas are relatively pristine compared to the many other wetland environments in Australia, and around the world, that have been extensively altered by humans. However, as the remote northern coastline of Australia becomes more populated, environmental problems are beginning to emerge that highlight the need to manage the tropical wetland environments. Lack of information is currently considered to be a major factor restricting the effective management of many ecosystems and for the expansive wetlands of the Northern Territory, this is especially the case, as these areas are generally remote and inaccessible. Remote sensing is therefore an attractive technique for obtaining relevant information on variables such as land cover and vegetation status. In the current study, Landsat TM, SPOT (XS and PANT) and large-scale, true-colour aerial photography were evaluated for mapping the vegetation of a tropical freshwater swamp in Australia's Top End. Extensive ground truth data were obtained, using a helicopter survey method. Fourteen cover types were delineated from 1:15 000 air photos (enlarged to 1:5000 in an image processing system) using manual interpretation techniques, with 89% accuracy. This level of detail could not be extracted from any of the satellite image data sets, with only three broad land-cover types identified with accuracy above 80%. The Landsat TM and SPOT XS data provided similar results although superior accuracy was obtained from Landsat, where the additional spectral information appeared to compensate in part for the coarser spatial resolution. Two different classification algorithms produced similar results.

  DOI：

  10.1080/01431160119174

文献信息

• LAMINATE AND METHOD FOR FORMATION THEREOF, INSULATING FILM, SEMICONDUCTOR DEVICE, AND COMPOSITION FOR FORMING FILM
  申请人：JSR Corporation

  公开号：EP1679184A1

  公开（公告）日：2006-07-12

  A laminate having a low relative dielectric constant and exhibiting excellent adhesion, a method of forming the laminate, an insulating film, a semiconductor device, and a film-forming composition are provided. A laminate according to the invention includes: a first silica-based film; a second silica-based film; and an organic film, wherein the second silica-based film includes a monovalent organic group containing a carbon-carbon double bond or a carbon-carbon triple bond. A method of forming a laminate according to the invention includes: forming a first coating for a first silica-based film on a substrate; forming a second coating for a second silica-based film on the first coating, the second coating including a monovalent organic group containing a carbon-carbon double bond or a carbon-carbon triple bond; forming a third coating for an organic film on the second coating; and curing a multilayer film including the first to third coatings.

  本发明提供了一种具有低相对介电常数并表现出优异附着力的层压板、一种形成该层压板的方法、一种绝缘膜、一种半导体器件和一种成膜组合物。 根据本发明的层压板包括：第一硅基薄膜；第二硅基薄膜；以及有机薄膜，其中第二硅基薄膜包括含有碳碳双键或碳碳三键的一价有机基团。 根据本发明形成层压板的方法包括：在基底上形成第一硅基薄膜的第一涂层；在第一涂层上形成第二硅基薄膜的第二涂层，第二涂层包括含有碳碳双键或碳碳三键的一价有机基团；在第二涂层上形成有机薄膜的第三涂层；以及固化包括第一至第三涂层的多层薄膜。
• Insulating film and method of forming the same
  申请人：Shiota Atsushi

  公开号：US20060210812A1

  公开（公告）日：2006-09-21

  A method of forming an insulating film includes: forming a polysiloxane insulating film on a substrate; forming a polycarbosilane insulating film on the polysiloxane insulating film; and forming an organic insulating film on the polycarbosilane insulating film. The polysiloxane insulating film is formed by hydrolysis and condensation of a silane compound, and the polycarbosilane insulating film is formed by applying a solution, obtained by dissolving a polycarbosilane compound in a solvent, to the polysiloxane insulating film, and heating the resulting coating,

  一种形成绝缘膜的方法包括：在基材上形成聚硅氧烷绝缘膜；在聚硅氧烷绝缘膜上形成聚碳硅烷绝缘膜；以及在聚碳硅烷绝缘膜上形成有机绝缘膜。聚硅氧烷绝缘膜是通过硅烷化合物的水解和缩合形成的，而聚碳硅烷绝缘膜则是通过将聚碳硅烷化合物溶解在溶剂中得到的溶液涂覆在聚硅氧烷绝缘膜上，并加热所形成的涂层而形成的、
• Crossley, Journal of the Chemical Society, 1904, vol. 85, p. 277
  作者：Crossley

  DOI：——

  日期：——
• Rearrangement of 4-Methyl-4-trichloromethyl-2,5-cyclohexadienols^1,2
  作者：Melvin S. Newman、John Eberwein、Louis L. Wood

  DOI：10.1021/ja01533a030

  日期：1959.12
• Polyphenylene co-polymers
  申请人：MISSISSIPPI POLYMER TECHNOLOGIES, INC.

  公开号：EP0773249B1

  公开（公告）日：2002-10-02