1,3-propyl dithioacetate | 36648-08-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硫代羧酸及其衍生物
• 英文名称: 1,3-propyl dithioacetate
• 英文别名: 1,3-Bis-acetylmercapto-propan；1,3-Bis-acetyl-propan；S,S-Diacetyl-1,3-dimercaptopropan；1,3-S-Diacetylpropan-1,3-dithiol；1,3-S-diacetyl-propane-1,3-dithiol；1,3-bis-acetylsulfanyl-propane；S-(3-acetylsulfanylpropyl) ethanethioate
• CAS: 36648-08-5
• 化学式: C₇H₁₂O₂S₂
• 分子量: 192.303
• InChiKey: QJVWXTVCEXXTOF-UHFFFAOYSA-N

物化性质

• 沸点：
  97-98 °C(Press: 0.5 Torr)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  84.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-propyl dithioacetate 在 磺酰氯 、 乙酸酐 作用下， 反应 1.0h， 以94%的产率得到Propan-(1,3)-disulfinylchlorid
  参考文献：
  名称：

  从硫代乙酸酯轻松合成亚硫酰氯

  摘要：

  烷基和芳基硫代乙酸盐在乙酸酐的存在下被硫酰氯平稳地转化为亚硫酰氯。

  DOI：

  10.1016/s0040-4039(00)95626-0
• 作为产物：
  描述：

  1,3-丙二硫醇 、 乙酰氯 在 吡啶 、 氯仿 作用下， 生成 1,3-propyl dithioacetate
  参考文献：
  名称：

  Mathias, 1942, # 1, p. 136

  摘要：

  DOI：

文献信息

• Cobalt(II) chloride catalysed coupling of thiols and anhydrides: A new and efficient synthesis of thiol esters
  作者：Saeed Ahmad、Javed Iqbal

  DOI：10.1016/s0040-4039(00)83882-4

  日期：1986.1

  Cobalt(II) chloride in acetonitrile catalyses the coupling of anhydrides or acid chlorides with thiols to yield thiol esters in excellent yields.

  乙腈中的氯化钴（II）催化酸酐或酰氯与硫醇的偶联，从而以优异的产率生成硫醇酯。
• Poly-(<i>N,N′</i>-dibromo-<i>N-</i>ethyl-benzene-1,3-disulfonamide) and<i>N,N,N′,N′</i>- Tetrabromobenzene-1,3-disulfonamide as Highly Efficient Catalysts, and (AC₂O/SIO₂) as a Heterogeneous System for the Acetylation of Alcohols, Amines, and Thiols Under Microwave Irradiation
  作者：Hojat Veisi、Ramin Ghorbani-Vaghei、Hosna Eskandari、Saba Hemmati、Ardashir Rezaei、Somaye Hajinazari、Mohammad Raoof Heidari Far、Azam Entezari

  DOI：10.1080/10426507.2010.496277

  日期：2011.1.31

  Abstract Poly-(N,N′-dibromo-N-ethyl-benzene-1,3-disulfonamide) (PBBS) and N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide (TBBDA) are good activators and catalytic reagents for the acetylation of alcohols, amines, and thiols. The presented method has the advantages of mild conditions, chemoselectivity, and good to high yields, and uses noncorrosive, inexpensive, recyclable, and environmentally friendly

  摘要 聚-(N,N'-二溴-N-乙基-苯-1,3-二磺酰胺) (PBBS) 和 N,N,N',N'-四溴苯-1,3-二磺酰胺 (TBBDA) 是良好的活化剂以及用于醇、胺和硫醇乙酰化的催化试剂。该方法具有条件温和、化学选择性好、收率高、使用无腐蚀性、价格低廉、可回收、环保的催化剂等优点。我们还证明，将 SiO2 与微波能量相结合，为合成单取代和双取代乙酸酯、乙酰胺和硫代乙酰胺提供了一种高效、快速、方便且简单的后处理程序。图形概要
• 432. Dithiols. Part XIX. Further studies on the deacetylation of acetylated dithiols
  作者：Peter S. Fitt、L. N. Owen

  DOI：10.1039/jr9570002240

  日期：——
• Hydrophobic Polymer-Supported Catalyst for Organic Reactions in Water:  Acid-Catalyzed Hydrolysis of Thioesters and Transprotection of Thiols
  作者：Shinya Iimura、Kei Manabe、Shū Kobayashi

  DOI：10.1021/ol026906m

  日期：2003.1.1

  A hydrophobic polystyrene-supported sulfonic acid was found to be effective for hydrolysis of thioesters in pure water. It was revealed that the catalyst was much superior to other Bronsted acid catalysts. Transprotection of thiols from thioesters to thioethers has been successfully performed in water using this catalytic system.
• Synthesis of Thiols via Palladium Catalyzed Methanolysis of Thioacetates with Borohydride Exchange Resin
  作者：Jaesung Choi、Nung Min Yoon

  DOI：10.1080/00397919508011812

  日期：1995.9

  Various thiols are prepared quantitatively from the corresponding thioacetates via Pd catalyzed methanolysis with borohydride exchange resin under a mild and neutral conditions. One-pot synthesis of thiols from alkyl halides through the formation of alkyl thioacetates using thioacetate exchange resin followed by methanolysis is also described.