2-乙基-己-2-烯酸酰胺 | 98552-26-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-乙基-己-2-烯酸酰胺
• 英文名称: 2-Ethyl-hexen-(2)-saeure-(1)-amid
• 英文别名: 2-ethyl-hex-2-enoic acid amide；2-Aethyl-hex-2-ensaeure-amid；2-Ethylhex-2-enamide
• CAS: 98552-26-2
• 化学式: C₈H₁₅NO
• mdl: MFCD19204536
• 分子量: 141.213
• InChiKey: QJGPWXUNWQAALY-UHFFFAOYSA-N

物化性质

• 熔点：
  67-68 °C(Solv: water (7732-18-5))
• 沸点：
  271.2±13.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-乙基-己-2-烯酸酰胺 在 单过氧邻苯二甲酸 作用下， 生成 奥沙那胺
  参考文献：
  名称：

  Composition of matter

  摘要：

  公开号：

  US02493090A1
• 作为产物：
  描述：

  2-Ethyl-hexen-(2)-saeure-(1)-chlorid 在 氨 作用下， 生成 2-乙基-己-2-烯酸酰胺
  参考文献：
  名称：

  Lott; Christiansen, Journal of the American Pharmaceutical Association (1912), 1934, vol. 23, p. 789

  摘要：

  DOI：

文献信息

• Proteasome inhibitors and methods of using the same
  申请人：Bernadini Raffaella

  公开号：US20050107307A1

  公开（公告）日：2005-05-19

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以通过抑制蛋白酶体活性等方式调节细胞凋亡。这些化合物和组合物可以用于诱导细胞凋亡并治疗癌症等疾病，以及与蛋白酶体活性直接或间接相关的其他疾病。
• Some 2,3-Disubstituted Glycidamides and Related Compounds¹
  作者：KEITH W. WHEELER、M. G. VAN CAMPEN、R. S. SHELTON

  DOI：10.1021/jo01076a040

  日期：1960.6
• [EN] SYNTHESIS OF COMBINATORIAL LIBRARIES OF COMPOUNDS REMINISCENT OF NATURAL PRODUCTS<br/>[FR] SYNTHESE COMBINATOIRE D'ECHANTILLOTHEQUES DE COMPOSES REMINISCENTS DE PRODUITS NATURELS
  申请人：HARVARD COLLEGE

  公开号：WO2000006525A2

  公开（公告）日：2000-02-10

  The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
• Lott; Christiansen, Journal of the American Pharmaceutical Association (1912), 1934, vol. 23, p. 789
  作者：Lott、Christiansen

  DOI：——

  日期：——
• Composition of matter
  申请人：WM S MERRELL CO

  公开号：US02493090A1

  公开（公告）日：1950-01-03