2-(4-Nitrophenoxy)carbonyloxyethyl prop-2-enoate | 1260541-91-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Nitrophenoxy)carbonyloxyethyl prop-2-enoate
• 英文别名: 2-(4-nitrophenoxy)carbonyloxyethyl prop-2-enoate
• CAS: 1260541-91-0
• 化学式: C₁₂H₁₁NO₇
• 分子量: 281.222
• InChiKey: XHLHNAPVDKALLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(4-Nitrophenoxy)carbonyloxyethyl prop-2-enoate 、 2-氨基-2-脱氧葡萄糖盐酸盐 在 三乙胺 、 对苯二酚 作用下， 以 二甲基亚砜 为溶剂， 反应 3.0h， 以67%的产率得到2-{[(D-glucosamin-2-N-yl)carbonyl]oxy}ethyl acrylate
  参考文献：
  名称：

  Glycopolymers with glucosamine pendant groups: Copolymerization, physico-chemical and interaction properties

  摘要：

  The synthesis of an unprotected glycomonomer, 2-{[(D-glucosamin-2-N-yl)carbonyl]oxy}ethyl acrylate (HEAGI) is firstly described as well as its copolymerization with methyl methacrylate by conventional free radical polymerization in DMSO solutions at 70 degrees C in a wide range of compositions. The reactions have been followed by in situ monitoring proton NMR which allows examining the system copolymerization kinetic as well as the variation of cumulative feed and copolymer compositions as a function of conversion. The monomer reactivity ratios have been calculated using the Mayo-Lewis terminal model and Kelen-Tudos extended equation. The glass transition and thermal stability temperatures have been determined in statistical glycopolymers obtained at high degree of conversions. Finally, the ability of the water-soluble glycopolymers to interact with Con A lectin has been investigated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2010.11.010
• 作为产物：
  描述：

  对硝基苯基氯甲酸酯 、 丙烯酸羟乙酯 以 二氯甲烷 为溶剂， 反应 18.0h， 以79%的产率得到2-(4-Nitrophenoxy)carbonyloxyethyl prop-2-enoate
  参考文献：
  名称：

  可聚合光敏单体、基于其的光敏聚合物及生物材料表面改性方法

  摘要：

  本发明涉及一种可聚合光敏单体、基于其的光敏聚合物及生物材料表面改性方法。本发明通过合成一种可聚合光敏单体，将其与亲水粘附性单体和活性单体进行聚合得到一种新结构的光敏聚合物，以此作为生物材料表面和生物活性分子间的“桥梁”，可以实现将生物活性分子共价负载到材料表面，增强材料的生物相容性。

  公开号：

  CN110835307B

文献信息

• Amphiphilic polymers bearing gluconolactone moieties: Synthesis and long side-chain crystalline behavior
  作者：María L. Cerrada、Vanesa Bordegé、Alexandra Muñoz-Bonilla、Orietta León、Rocío Cuervo-Rodríguez、Manuel Sánchez-Chaves、Marta Fernández-García

  DOI：10.1016/j.carbpol.2013.01.053

  日期：2013.5

  The synthesis and characterization of amphiphilic polymers bearing gluconolactone moieties has been described. In a first step, an unprotected glycomonomer 2-[([4-(d-gluconamid-N-yl)butyl]amino}carbonyl)oxy]ethyl acrylate, HEAG, has been synthesized. Posterior, this glycomonomer has been copolymerized with methyl methacrylate at different compositions and the kinetic behavior has been also studied

  已经描述了带有葡糖酸内酯部分的两亲聚合物的合成和表征。在第一步中，合成了未保护的丙烯酸单体2-[（（（[[4-（d-葡糖酰胺基-N-基）丁基]氨基}羰基）氧基]乙基）糖基单体HEAG。此后，该糖单体已与甲基丙烯酸甲酯以不同的组成进行共聚，并且还通过Kelen-Tüdös扩展方程研究了动力学行为，计算了单体的反应率。另外，已经通过使用常规的和调制的差示扫描量热法和X射线衍射测量法检查了这些具有高糖基单体组成的基于碳水化合物的共聚物的长侧链结晶行为。同时，具有较低HEAG含量的碳水化合物基共聚物的相分离行为已通过其玻璃化转变温度测量来确定。最后，所有这些两亲共聚物的热稳定性已通过热重分析进行了评估。
• 可聚合光敏单体、基于其的光敏聚合物及生物材料表面改性方法
  申请人：江苏百赛飞生物科技有限公司

  公开号：CN110835307B

  公开（公告）日：2023-04-07

  本发明涉及一种可聚合光敏单体、基于其的光敏聚合物及生物材料表面改性方法。本发明通过合成一种可聚合光敏单体，将其与亲水粘附性单体和活性单体进行聚合得到一种新结构的光敏聚合物，以此作为生物材料表面和生物活性分子间的“桥梁”，可以实现将生物活性分子共价负载到材料表面，增强材料的生物相容性。
• Glycopolymers with glucosamine pendant groups: Copolymerization, physico-chemical and interaction properties
  作者：Vanesa Bordegé、Alexandra Muñoz-Bonilla、Orietta León、Manuel Sánchez-Chaves、Rocío Cuervo-Rodríguez、Marta Fernández-García

  DOI：10.1016/j.reactfunctpolym.2010.11.010

  日期：2011.1

  The synthesis of an unprotected glycomonomer, 2-[(D-glucosamin-2-N-yl)carbonyl]oxy}ethyl acrylate (HEAGI) is firstly described as well as its copolymerization with methyl methacrylate by conventional free radical polymerization in DMSO solutions at 70 degrees C in a wide range of compositions. The reactions have been followed by in situ monitoring proton NMR which allows examining the system copolymerization kinetic as well as the variation of cumulative feed and copolymer compositions as a function of conversion. The monomer reactivity ratios have been calculated using the Mayo-Lewis terminal model and Kelen-Tudos extended equation. The glass transition and thermal stability temperatures have been determined in statistical glycopolymers obtained at high degree of conversions. Finally, the ability of the water-soluble glycopolymers to interact with Con A lectin has been investigated. (C) 2010 Elsevier Ltd. All rights reserved.