1,5-萘二甲酸 | 7315-96-0

• 物质功能分类: 化学试剂 - 有机试剂 - 多环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1,5-萘二甲酸
• 英文名称: naphthalene-1,5-dicarboxylic acid
• 英文别名: 1,5-naphthalenedicarboxylic acid；1,5-Naphthalindicarbonsaeure；1,5-Dicarboxy-naphthalin
• CAS: 7315-96-0
• 化学式: C₁₂H₈O₄
• 分子量: 216.193
• InChiKey: DFFZOPXDTCDZDP-UHFFFAOYSA-N

物化性质

• 熔点：
  390 °C (decomp)
• 沸点：
  511.6±23.0 °C(Predicted)
• 密度：
  1.454±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  1,5-萘二甲酸 在 氨 、 sodium 作用下， 以 乙醇 为溶剂， 生成 1,4,5,8-Tetrahydro-1,5-dicarboxy-naphthalin
  参考文献：
  名称：

  HEPTALENIUM ION

  摘要：

  DOI：

  10.1021/ja01483a037
• 作为产物：
  描述：

  萘-1,5-二腈 在 硫酸 作用下， 生成 1,5-萘二甲酸
  参考文献：
  名称：

  Cyclic Acetylenes. X. A Transannular Hypochromism Observed in a Cyclic Diacetylene Containing a Naphthalene Nucleus

  摘要：

  通过1,5-双(丙炔氧甲基)萘(X)与环状二聚体(XIb)和环状三聚体(XIc)的氧化耦合反应，合成了一种环状二炔(XIa)。研究发现，XIb和XIc的电子光谱与萘的吸收最大位置和强度几乎相同。另一方面，在环状单体(XIa)的光谱中观察到了明显的吸收强度下降。对XIa的Dreiding模型的检查表明，两种构象(A和B)能够保持二炔单元和萘核之间的最大距离。基于分子模型，估计了两个发色团之间的距离和核短轴与桥链之间的角度，分别为A的2.26 Å和21°，B的2.12 Å和38°。利用这些数据，根据Tinoco和Rhodes的理论计算了二炔发色团对萘核吸收的减色效应，结果与观察值相当一致。相反，使用观察到的减色效应计算两个发色团之间的距离和角度也给出了合理值。因此，观察到的环状二炔(XIa)的减色效应归因于二炔单元和萘发色团之间的色散力相互作用。

  DOI：

  10.1246/bcsj.40.363

文献信息

• Highly Selective and Efficient Conversion of Alkyl Aryl and Alkyl Cyclopropyl Ketones to Aromatic and Cyclopropane Carboxylic Acids by Aerobic Catalytic Oxidation: A Free-radical Redox Chain Mechanism.
  作者：Francesco Minisci、Francesco Recupero、Francesca Fontana、Hans-René Bjørsvik、Lucia Liguori

  DOI：10.1055/s-2002-22706

  日期：——

  An efficient and convenient method has been developed for the oxidation of aryl alkyl and cyclopropyl alkyl ketones to aromatic and cyclopropane carboxylic acids by molecular oxygen at atmospheric pressure, catalysed by Mn(NO 3 ) 2 in combination with Co(NO 3 ) 2 or Cu(NO 3 ) 2 . This simple, cheap and highly selective process has a general character for the synthesis of carboxylic acids and it is

  已开发出一种在常压下通过分子氧在 Mn(NO 3 ) 2 与 Co(NO 3 ) 2 或 Cu 的组合催化下将芳基烷基和环丙基烷基酮氧化成芳香族和环丙烷羧酸的高效便捷方法。 （否 3） 2．这种简单、廉价和高选择性的方法具有合成羧酸的通用特性，特别适合工业应用。
• Cyclic Acetylenes. X. A Transannular Hypochromism Observed in a Cyclic Diacetylene Containing a Naphthalene Nucleus
  作者：Takashi Ando、Masazumi Nakagawa

  DOI：10.1246/bcsj.40.363

  日期：1967.2

  A cyclic diacetylene (XIa) has been synthesized by the oxidative coupling of 1, 5-bis(propargyloxymethyl)naphthalene (X) with a cyclic dimer (XIb) and a cyclic trimer (XIc). The electronic spectra of XIb and XIc have been found to be almost identical with that of naphthalene with respect to the location of the absorption maxima and the intensities. On the other hand, a marked decrease in the absorption intensities has been observed in the spectrum of the cyclic monomer (XIa). An inspection of the Dreiding model of XIa indicates that the two conformations (A and B) can retain the maximum distance between the dyine unit and the naphthalene nucleus. On the basis of the molecular model, the distance between the two chromophores and the angle between the short axis of the nucleus and the bridging chain have been estimated to be 2.26 Å, 21° for A and 2.12 Åand 38° for B. Employing these data, the hypochromic effect exerted by the diyne chromophore on the absorption of the naphthalene nucleus has been calculated according to the theory of Tinoco and Rhodes, resulting in a fairly good agreement with the observed values. Inversely, the calculation of the distance and the angle between the two chromophoric groups using the observed hypochromic effect has also given reasonable values. Therefore, the hypochromism observed in the cyclic diacetylene (XIa) has been attributed to the operation of dispersion-force interaction between diyne unit and the naphthalene chromophore.

  通过1,5-双(丙炔氧甲基)萘(X)与环状二聚体(XIb)和环状三聚体(XIc)的氧化耦合反应，合成了一种环状二炔(XIa)。研究发现，XIb和XIc的电子光谱与萘的吸收最大位置和强度几乎相同。另一方面，在环状单体(XIa)的光谱中观察到了明显的吸收强度下降。对XIa的Dreiding模型的检查表明，两种构象(A和B)能够保持二炔单元和萘核之间的最大距离。基于分子模型，估计了两个发色团之间的距离和核短轴与桥链之间的角度，分别为A的2.26 Å和21°，B的2.12 Å和38°。利用这些数据，根据Tinoco和Rhodes的理论计算了二炔发色团对萘核吸收的减色效应，结果与观察值相当一致。相反，使用观察到的减色效应计算两个发色团之间的距离和角度也给出了合理值。因此，观察到的环状二炔(XIa)的减色效应归因于二炔单元和萘发色团之间的色散力相互作用。
• Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists
  作者：Matthew D. Morin、Ying Wang、Brian T. Jones、Yuto Mifune、Lijing Su、Hexin Shi、Eva Marie Y. Moresco、Hong Zhang、Bruce Beutler、Dale L. Boger

  DOI：10.1021/jacs.8b09223

  日期：2018.10.31

  from treated human THP-1 myeloid cells differentiated along the macrophage line led to the discovery of the diprovocims. Unique to these efforts and of special interest, the screening leads for this new class of activators of an immune response came from a compound library designed to promote cell-surface receptor dimerization. Subsequent comprehensive structure-activity relationship studies improved the

  使用近 100000 种化合物进行的筛选和用于刺激免疫反应的替代功能测定法测量了 TNF-α 从沿巨噬细胞系分化的处理过的人 THP-1 骨髓细胞中的释放，导致发现了双源蛋白。这些努力的独特之处和特别令人感兴趣的是，这类新型免疫反应激活剂的筛选线索来自旨在促进细胞表面受体二聚化的化合物库。随后的综合构效关系研究将效力提高了 800 倍于筛选先导物的效力，提供了 diprovocim-1 和 diprovocim-2。diprovocims 通过用 TLR1（TLR1/TLR2 激动剂）诱导细胞表面 toll 样受体 (TLR)-2 二聚化和活化而起作用，与任何已知的天然或合成 TLR 激动剂没有结构相似性，并且易于制备和合成修饰，并且选定的成员在人类和鼠类系统中都很活跃。最有效的 diprovocim (3, diprovocim-1) 在人 THP-1 细胞中以极低的浓度 (EC50 =
• NOVEL TETRACARBOXYLIC DIANHYDRIDE, POLYIMIDE RESIN AND METHOD FOR PRODUCING THE SAME, PHOTOSENSITIVE RESIN COMPOSITIONS, PATTERNING PROCESS, METHOD FOR FORMING CURED FILM, INTERLAYER INSULATING FILM, SURFACE PROTECTIVE FILM, AND ELECTRONIC PARTS
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20190169211A1

  公开（公告）日：2019-06-06

  The present invention has been made in view of the circumstances herein. An object of the present invention is to provide: a tetracarboxylic dianhydride which can lead to a polyimide usable as a base resin of a photosensitive resin composition capable of forming a fine pattern and obtaining high resolution without impairing excellent characteristics such as mechanical strength and adhesiveness; a polyimide resin obtained by using the tetracarboxylic dianhydride; and a method for producing the polyimide resin. The tetracarboxylic dianhydride is shown by the following general formula (1).

  本发明是基于本文中的情况而作出的。本发明的目的是提供：一种四羧酸二酐，可导致聚酰亚胺，作为感光树脂组合物的基树脂，能够形成细微图案并获得高分辨率，同时不损害优异的特性，如机械强度和粘附性；通过使用该四羧酸二酐获得的聚酰亚胺树脂；以及生产该聚酰亚胺树脂的方法。该四羧酸二酐由以下通用式（1）所示。
• THIOGLUCOSE SPIROKETAL DERIVATIVE AND USE THEREOF AS THERAPEUTIC AGENT FOR DIABETES
  申请人：Sato Tsutomu

  公开号：US20100093744A1

  公开（公告）日：2010-04-15

  The present invention provides a compound represented by Formula (II): wherein R 1 , R 2 , R 3 , and R 4 are each independently selected from a hydrogen atom, an optionally substituted C 1 -C 6 alkyl group, an optionally substituted C 7 -C 14 aralkyl group and —C(═O)Rx; Rx is an optionally substituted C 1 -C 6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C 1 -C 6 alkoxy group or —NReRf; Ar 1 is an optionally substituted aromatic carbocyclic ring, or an optionally substituted aromatic heterocyclic ring which may form a condensed ring; Q is —(CH 2 ) m -(L) p - or -(L) p -(CH 2 ) m —; m is an integer selected from 0 to 2, n is an integer selected from 1 and 2, and p is an integer selected from 0 and 1; L is —O—, —S— or —NR 5 —; A is an optionally substituted aryl group or an optionally substituted heteroaryl group; and a prodrug thereof and a pharmaceutically acceptable salt thereof, and a pharmaceutical agent or a pharmaceutical composition, which comprises the compound.

  本发明提供了一种由Formula (II)表示的化合物：其中R1、R2、R3和R4分别独立地选自氢原子、可选取代的C1-C6烷基、可选取代的C7-C14芳基烷基和—C(═O)Rx；Rx是可选取代的C1-C6烷基、可选取代的芳基、可选取代的杂环芳基、可选取代的C1-C6甲氧基或—NReRf；Ar1是可选取代的芳香环碳环或可选取代的芳香杂环环，可能形成一个融合环；Q是—(CH2)m-(L)p-或-(L)p-(CH2)m—；m是选自0到2的整数，n是选自1和2的整数，p是选自0和1的整数；L是—O—、—S—或—NR5—；A是可选取代的芳基或可选取代的杂环芳基；以及其前体藥物和其藥學上可接受的鹽，以及包含该化合物的藥物代理或藥物组合物。