(3-bromo-4-fluorophenyl)(phenyl)methanone | 13294-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-bromo-4-fluorophenyl)(phenyl)methanone
• 英文别名: 3-bromo-4-fluorobenzophenone；4-Benzoyl-2-brom-1-fluor-benzol；(3-Bromo-4-fluorophenyl)-phenylmethanone
• CAS: 13294-41-2
• 化学式: C₁₃H₈BrFO
• 分子量: 279.108
• InChiKey: VWOZIQBAVAZRRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3-bromo-4-fluorophenyl)(phenyl)methanone 在 正丁基锂 、 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 反应 28.0h， 生成 5-乙酰基-2-氟苯硼酸
  参考文献：
  名称：

  CN116425782

  摘要：

  公开号：
• 作为产物：
  描述：

  3-溴-4-氟苯甲醇 在 N-溴代丁二酰亚胺(NBS) 、 三氟化硼乙醚 、 水 作用下， 以 氯仿 为溶剂， 反应 5.0h， 生成 (3-bromo-4-fluorophenyl)(phenyl)methanone
  参考文献：
  名称：

  Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 CH oxidation

  摘要：

  Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on O-18-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.06.047

文献信息

• [EN] PYRROLOPYRIDONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF<br/>[FR] COMPOSÉ DE PYRROLOPYRIDONE, PROCÉDÉ DE PRÉPARATION CORRESPONDANT, COMPOSITION ET UTILISATION ASSOCIÉES<br/>[ZH] 一种吡咯并吡啶酮类化合物、其制备方法、其组合物和用途
  申请人：SHANGHAI INST MATERIA MEDICA CAS

  公开号：WO2020253711A1

  公开（公告）日：2020-12-24

  一种吡咯并吡啶酮类化合物或其药学上可接受的盐，以及它们的制备方法和用途。所述吡咯并吡啶酮类化合物具有I所示的结构。该化合物具有BRD4和HDAC双靶抑制活性的特点和/或具有靶向泛素化降解BRD4蛋白功能的特点，可应用于与该靶点相关的抗肿瘤等相关疾病。
• POLY(ARYLENE ETHER) COMPOSITIONS AND METHODS OF MANUFACTURE THEREOF
  申请人：AlliedSignal Inc.

  公开号：EP1068255A2

  公开（公告）日：2001-01-17
• [EN] POLY(ARYLENE ETHER) COMPOSITIONS AND METHODS OF MANUFACTURE THEREOF<br/>[FR] COMPOSITIONS DE POLY(ARYLENE ETHER) ET LEURS PROCEDES DE FABRICATION
  申请人：——

  公开号：WO1999029761A2

  公开（公告）日：1999-06-17

  [EN] Dielectric compositions encompassing one or more poly(arylene ether) polymers are provided. The dielectric compositions have repetitive structural unit (I) where n=0 to 1; m=0 to 1-n; and Y1, Y2, Ar1 and Ar2 are each a divalent arylene radical, Y1 and Y2 derived from biphenol compounds, Ar1 derived from difluoroarylethynes and Ar2 derived from difluoroaryl compounds. Where both Y1 and Y2 are derived from fluorene bisphenol, n=0.1 to 1. Such poly(arylene ether) polymers are employed with a variety of microelectronic devices, for example, integrated circuits and multichip modules.
  [FR] L'invention concerne des compositions diélectriques comprenant un ou plusieurs polymères de poly(arylène éther). Ces compositions diélectriques renferment le motif de structure répété (I) dans lequel n est égal à 0 ou 1; m est égal à 0 ou 1; et Y1, Y2; Ar1 et Ar2 sont chacun un radical arylène divalent, Y1 et Y2 sont des dérivés de composés bisphénol, Ar1 est un dérivé de difluoroaryléthynes et Ar2 est un dérivé de composés difluoroaryle. Lorsqu'à la fois Y1 et Y2 sont dérivés de fluorène bisphénol, n est compris entre 0,1 et 1. De tels polymères de poly(arylène éther) sont employés dans divers dispositifs microélectroniques, tels que les circuits intégrés et les boîtiers multipuces.
• [EN] POLY(ARYLENE ETHER) HOMOPOLYMER COMPOSITIONS AND METHODS OF MANUFACTURE THEREOF<br/>[FR] COMPOSITIONS A BASE DE POLY(ARYLENE ETHER) HOMOPOLYMERE ET PROCEDES DE FABRICATION
  申请人：ALLIED SIGNAL INC

  公开号：WO2000031163A2

  公开（公告）日：2000-06-02

  Dielectric compositions encompassing one or more poly(arylene ether) polymers are provided. The dielectric compositions have the repetitive structural unit formula (I) where n=l to 200, Y and Ar are each a divalent arylene radical, Y derived from bisphenol compounds of general formula HO-Y-OH, Ar derived from difluoro diarylacetylenes and/or ethynylated benzophenones of general formula F-Ar-F and Z is optionally hydrogen, a methyl group or derived from a monofluoro-benzophenone derivative of general formula Z-F. Such poly(arylene ether) polymers are employed with a variety of microelectronic devices, for example, integrated circuits and multichip modules.
• Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 CH oxidation
  作者：Chao He、Xiaohui Zhang、Ruofeng Huang、Jing Pan、Jiaqiang Li、Xuege Ling、Yan Xiong、Xiangming Zhu

  DOI：10.1016/j.tetlet.2014.06.047

  日期：2014.8

  Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on O-18-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases. (C) 2014 Elsevier Ltd. All rights reserved.