(S)-2-hydroxynonanoic acid | 70267-28-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-2-hydroxynonanoic acid
• 英文别名: (2S)-2-hydroxynonanoic acid
• CAS: 70267-28-6
• 化学式: C₉H₁₈O₃
• 分子量: 174.24
• InChiKey: BTJFTHOOADNOOS-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-2-hydroxynonanoic acid 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 16.0h， 以84%的产率得到(S)-nonane-1,2-diol
  参考文献：
  名称：

  Convenient synthesis of (±)- and (S)-antipode of (4E,7S)-7-methoxytetradec-4-enoic acid, the antimicrobial principle of marine cyanophyte

  摘要：

  The (+/-)- and S-isomers of title compound I were prepared via a short and efficient route. The key features of the synthesis were the use of easily accessible materials, operationally simple reaction protocol and highly enantioselective lipase catalyzed esterification for the generation of the required chiron. Copyright (C) 1996 Published by Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00339-4
• 作为产物：
  描述：

  2-hydroxy-nonanenitrile 在 盐酸 作用下， 反应 6.0h， 生成 (S)-2-hydroxynonanoic acid
  参考文献：
  名称：

  Convenient synthesis of (±)- and (S)-antipode of (4E,7S)-7-methoxytetradec-4-enoic acid, the antimicrobial principle of marine cyanophyte

  摘要：

  The (+/-)- and S-isomers of title compound I were prepared via a short and efficient route. The key features of the synthesis were the use of easily accessible materials, operationally simple reaction protocol and highly enantioselective lipase catalyzed esterification for the generation of the required chiron. Copyright (C) 1996 Published by Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00339-4

文献信息

• Hydroxamic acid derivatives and pharmaceutical compositions thereof
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0575844B1

  公开（公告）日：1998-01-21
• Convenient synthesis of (±)- and (S)-antipode of (4E,7S)-7-methoxytetradec-4-enoic acid, the antimicrobial principle of marine cyanophyte
  作者：S. Sankaranarayanan、Anubha Sharma、Subrata Chattopadhyay

  DOI：10.1016/0957-4166(96)00339-4

  日期：1996.9

  The (+/-)- and S-isomers of title compound I were prepared via a short and efficient route. The key features of the synthesis were the use of easily accessible materials, operationally simple reaction protocol and highly enantioselective lipase catalyzed esterification for the generation of the required chiron. Copyright (C) 1996 Published by Elsevier Science Ltd