cis-6-amino-cyclohex-3-enecarboxylic acid ethyl ester hydrochloride | 859176-88-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-6-amino-cyclohex-3-enecarboxylic acid ethyl ester hydrochloride
• 英文别名: Ethyl 6-aminocyclohex-3-ene-1-carboxylate
• CAS: 859176-88-8
• 化学式: C₉H₁₅NO₂
• mdl: MFCD20542843
• 分子量: 169.224
• InChiKey: PTXUIEXYXGXMEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-6-amino-cyclohex-3-enecarboxylic acid ethyl ester hydrochloride 在 水 作用下， 以 异丙醚 为溶剂， 生成 (1R,2S) ethyl 2-amino-1-cyclohex-4-enecarboxylate 、 cis-2-aminocyclohex-4-enecarboxylic acid
  参考文献：
  名称：

  Efficient synthesis of 3,4- and 4,5-dihydroxy-2-amino-cyclohexanecarboxylic acid enantiomers

  摘要：

  An efficient method for the synthesis of (1S,2R,4R,5S)- and (1R,2R,4R,5S)-2-amino-4,5-dihydroxycyclohexanecarboxylic acids (-)-6 and (-)-9 and (1R,2R,3S,4R)- and (1S,2R,3S,4R)-2-amino-3,4-dihydroxycyclohexanecarboxylic acids (-)-15 and (-)-18 was developed by using the OsO4-catalyzed oxidation of Boc-protected (1S,2R)-2-aminocyclohex-4-enecarboxylic acid (+)-2 and (1R,2S)-2-aminocyclohex-3-ene-carboxylic acid (+)-11. Good yields were obtained. The stereochemistry of the synthesized compounds was proven by NMR spectroscopy. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.09.001

文献信息

• INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE
  申请人：Hurley Timothy Brian

  公开号：US20090325948A1

  公开（公告）日：2009-12-31

  The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these compounds for treating bacterial disease, such as bacterial infection.

  本发明涉及选择性和/或有效抑制UPPS的化合物。除了抑制UPPS的化合物外，本发明还提供包含这些化合物的药物组合物以及使用这些化合物治疗细菌性疾病，如细菌感染的方法。
• 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
  申请人：Tran Chinh V.

  公开号：US20090111798A1

  公开（公告）日：2009-04-30

  The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

  本发明涉及5,6-二氢-1H-吡啶-2-酮化合物和含有这些化合物的药物组合物，用于治疗丙型肝炎病毒感染。
• WO2008/73982
  申请人：——

  公开号：——

  公开（公告）日：——
• FULOP, FERENC;BERNATH, GABOR;CSIRINYI, GYORGY, ORG. PREP. AND PROCED. INT., 20,(1988) N 1-2, 73-82
  作者：FULOP, FERENC、BERNATH, GABOR、CSIRINYI, GYORGY

  DOI：——

  日期：——
• US7582626B2
  申请人：——

  公开号：US7582626B2

  公开（公告）日：2009-09-01