p-Nitro-d-amphetamine hydrochloride | 54422-92-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Nitro-d-amphetamine hydrochloride
• 英文别名: p-nitroamphetamine hydrochloride；1-methyl-2-(4-nitro-phenyl)-ethylamine; hydrochloride；1-Methyl-2-(4-nitro-phenyl)-aethylamin; Hydrochlorid；alpha-Methyl-p-nitrophenethylamine hydrochloride；1-(4-nitrophenyl)propan-2-amine;hydrochloride
• CAS: 54422-92-3
• 化学式: C₉H₁₂N₂O₂*ClH
• 分子量: 216.667
• InChiKey: HSTFPFCLQRUECF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.91
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-Nitro-d-amphetamine hydrochloride 生成 3-[1-methyl-2-(4-nitro-phenyl)-ethyl]-5-(3-phenyl-ureido)-[1,2,3]oxadiazolium betaine
  参考文献：
  名称：

  Electrophilic substitution in a number of N-exo-carbamoyl derivatives of sydnoneimines

  摘要：

  DOI：

  10.1007/bf00471291
• 作为产物：
  描述：

  硫酸苯丙胺 在 sodium hydroxide 、 ethereal hydrochloric acid 、 硝酸 作用下， 以 硫酸 、 丙酮 为溶剂， 以3.5g (60%)的产率得到p-Nitro-d-amphetamine hydrochloride
  参考文献：
  名称：

  CROSSTALK INHIBITORS AND THEIR USES

  摘要：

  公开号：

  EP0585310B1

文献信息

• Amphetamine derivatives and protein and polypeptide amphetamine
  申请人：Biosite Diagnostics Incorporated

  公开号：US05470997A1

  公开（公告）日：1995-11-28

  The present invention is directed to novel amphetamine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to amphetamine and amphetamine metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.

  本发明涉及一种新型苯丙胺衍生物，用于与抗原（蛋白质或多肽）共价结合，以制备针对苯丙胺及其代谢产物的抗体或受体。所得的新型抗原可用于使用标准方法制备抗体或受体。一旦生成，这些抗体或受体以及与蛋白质、多肽或标记物共价结合的新型衍生物可在免疫分析过程中使用。
• Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
  申请人：American Home Products Corporation

  公开号：US20020025973A1

  公开（公告）日：2002-02-28

  This invention provides compounds of Formula I having the structure 1 wherein, 2 R 1 , R 2 , and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type 11 diabetes.

  这项发明提供了具有结构1的Formula I化合物，其中，2R1、R2和X如前文所定义，或其药学上可接受的盐，这些化合物在治疗或抑制与胰岛素抵抗或高血糖相关的代谢紊乱（通常与肥胖或葡萄糖不耐症相关）、动脉粥样硬化、胃肠道紊乱、神经遗传性炎症、青光眼、眼压升高和频繁排尿方面具有用处；尤其在治疗或抑制2型糖尿病方面特别有用。
• Fluorescence polarization immunoassay for amphetamine/methamphetamine
  申请人：ABBOTT LABORATORIES

  公开号：EP0279213A1

  公开（公告）日：1988-08-24

  This disclosure related to a method and reagents for determining amphetamine and methamphetamine in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as β-hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4.0 to about 7.5 without adjustment to an alkaline pH.

  本公开涉及一种测定生物液体（如尿液）中苯丙胺和甲基苯丙胺的方法和试剂。 特别是，本公开涉及一种荧光偏振免疫测定程序，用于在一次测定中确定苯丙胺和甲基苯丙胺的存在，还涉及在此类程序中用作试剂的一类新型示踪化合物。 所述程序包括对生物样品进行预处理，以消除交叉反应物，如β-羟苯乙胺，方法是仅将样品与pH值为约4.0至约7.5的高碘酸盐水溶液预孵育，而不将pH值调整为碱性。
• DUTERTE, D.;MORIER, E.;LE, PONCIN-LAFITTE, M.;RAPIN, J. R.;RIPS, R., J. LABELLED COMPOUNDS AND RADIOPHARM., 1983, 20, N 1, 149-155
  作者：DUTERTE, D.、MORIER, E.、LE, PONCIN-LAFITTE, M.、RAPIN, J. R.、RIPS, R.

  DOI：——

  日期：——
• OLOVYANISHNIKOVA Z. A.; BRYANTSEV B. I.; SLYUSARENKO I. S.; YASHUNSKIJ V.+, XIMIYA GETEROTSIKL. SOEDIN. <KGSS-AQ>, 1975, HO 9, 1198-1203
  作者：OLOVYANISHNIKOVA Z. A.、 BRYANTSEV B. I.、 SLYUSARENKO I. S.、 YASHUNSKIJ V.+

  DOI：——

  日期：——