1-(2-methoxyphenyl)-2-(p-tosyl)-4,5,6,7-tetrahydro-2H-isoindole | 1427329-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(2-methoxyphenyl)-2-(p-tosyl)-4,5,6,7-tetrahydro-2H-isoindole
• CAS: 1427329-74-5
• 化学式: C₂₂H₂₃NO₃S
• 分子量: 381.496
• InChiKey: LQKBULFLAVVNCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.59
• 重原子数：
  27.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  48.3
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-(2-methoxyphenyl)-2-(p-tosyl)-4,5,6,7-tetrahydro-2H-isoindole 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 1-(2-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindole
  参考文献：
  名称：

  Application of In Situ-Generated Rh-Bound Trimethylenemethane Variants to the Synthesis of 3,4-Fused Pyrroles

  摘要：

  Rh-bound trimethylenemethane variants generated from the interaction of a Rh-carbenoid with an allene have been applied to the synthesis of substituted 3,4-fused pyrroles. The pyrrole products are useful starting points for the syntheses of various dipyrromethene ligands. Furthermore, the methodology has been applied to a synthesis of the natural product cycloprodigiosin, which demonstrates antitumor and immunosuppressor activity.

  DOI：

  10.1021/ja401380d
• 作为产物：
  描述：

  1-methoxy-2-(octa-1,2-dien-7-yn-1-yl)benzene 在 噻吩-2-甲酸亚铜(I) 、 辛酸铑 作用下， 以 氯仿 为溶剂， 生成 1-(2-methoxyphenyl)-2-(p-tosyl)-4,5,6,7-tetrahydro-2H-isoindole
  参考文献：
  名称：

  Application of In Situ-Generated Rh-Bound Trimethylenemethane Variants to the Synthesis of 3,4-Fused Pyrroles

  摘要：

  Rh-bound trimethylenemethane variants generated from the interaction of a Rh-carbenoid with an allene have been applied to the synthesis of substituted 3,4-fused pyrroles. The pyrrole products are useful starting points for the syntheses of various dipyrromethene ligands. Furthermore, the methodology has been applied to a synthesis of the natural product cycloprodigiosin, which demonstrates antitumor and immunosuppressor activity.

  DOI：

  10.1021/ja401380d