2-acetylpyridine 4-(3-fluorophenyl)-3-thiosemicarbazone | 70618-03-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-acetylpyridine 4-(3-fluorophenyl)-3-thiosemicarbazone
• 英文别名: 1-(3-Fluorophenyl)-3-(1-pyridin-2-ylethylideneamino)thiourea
• CAS: 70618-03-0
• 化学式: C₁₄H₁₃FN₄S
• 分子量: 288.348
• InChiKey: VCKFVZSNSWYSKQ-UHFFFAOYSA-N

物化性质

• 熔点：
  159-160 °C(Solv: acetonitrile (75-05-8))
• 沸点：
  412.4±51.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-乙酰基吡啶 、 4-(3-氟苯基)-3-氨基硫脲 以 乙醇 为溶剂， 生成 2-acetylpyridine 4-(3-fluorophenyl)-3-thiosemicarbazone
  参考文献：
  名称：

  2-Acetyl-and 2-propionylpyridine thiosemicarbazones

  摘要：

  本发明涉及各种2-乙酰基和2-丙酰基吡啶硫代缩氨脲，它们在4-氮原子上被取代。这些化合物在治疗淋病方面有用，此外，许多化合物还可用于治疗疟疾或细菌感染。还公开了几种用于制备硫代缩氨脲的合成方法。

  公开号：

  US04317776A1

文献信息

• Transition metal complexes of the selenium analogs of 2-acetyl- and
  申请人：The United States of America as represented by the Secretary of the Army

  公开号：US04657903A1

  公开（公告）日：1987-04-14

  This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones and their selenium analogs.

  本发明涉及新颖的2-乙酰基和-丙酰基吡啶硫代半卡巴踪的过渡金属配合物及其硒类似物。这些化合物作为抗疟疾和抗白血病药物具有用途。还公开了几种用于制备硫代半卡巴踪及其硒类似物的合成方法。
• 2-acetyl- and 2-propionylpyridine selenosemicarbazones
  申请人：——

  公开号：US04665173A1

  公开（公告）日：1987-05-12

  This invention relates to novel 2-acetyl- and 2-propionylpyridine selenosemicarbazones. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the selenosemicarbazones.

  本发明涉及新颖的2-乙酰基和2-丙酰基吡啶硒半卡巴脒。这些化合物作为抗疟疾和抗白血病药物具有应用价值。同时还披露了几种用于制备这些硒半卡巴脒的合成方法。
• Heterocyclic and aromatic thiosemicarbazones useful in the treatment of
  申请人：The United States of America as represented by the Secretary of the Army

  公开号：US05281597A1

  公开（公告）日：1994-01-25

  This invention is directed to heterocyclic and aromatic thiosemicarbazones seful in the treatment of filariasis and in an animal, including humans.

  本发明涉及用于治疗丝虫病以及包括人类在内的动物的杂环和芳香硫代半卡巴脒。
• 2-acetylpyridine thiosemicarbazones as antiviral agents
  申请人：The United States of America as represented by the Secretary of the Army

  公开号：US04596798A1

  公开（公告）日：1986-06-24

  This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

  本发明涉及用于治疗病毒感染的各种4-氮原子取代的2-乙酰基吡啶硫代半卡巴宗的使用。还公开了几种用于制备这些硫代半卡巴宗的合成程序。
• 2-acetylpyridine thiosemicarbazone compositions as anitviral agents
  申请人：The United States of America as represented by the Secretary of the Army

  公开号：US04777166A1

  公开（公告）日：1988-10-11

  This invention relates to various compositions, comprising a 2-acetylprid thiosemicarbazone and a diol, which are useful in the treatment of viral infections.

  本发明涉及各种组合物，包含2-乙酰吡啶硫代半卡巴脒和二醇，这些组合物在治疗病毒感染方面具有用途。