2,6-dibromobenzoyl chloride | 59870-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dibromobenzoyl chloride
• CAS: 59870-37-0
• 化学式: C₇H₃Br₂ClO
• 分子量: 298.361
• InChiKey: JSWZDJLKJUQFRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-dibromobenzoyl chloride 在 ammonium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2,6-dibromobenzamide
  参考文献：
  名称：

  铱催化配体控制的远程对位选择性 C-H 活化和扭曲芳族酰胺的硼化

  摘要：

  报道了芳族酰胺的高度对位选择性 C-H 硼基化。对位硼化通过扭曲的芳香酰胺和新设计的配体框架（defa）之间前所未有的底物-配体扭曲进行，这与标准的硼化配体不同。使用这种 defa 配体开发了一种新型催化系统，该配体对一系列芳族酰胺表现出优异的对位选择性。

  DOI：

  10.1002/anie.202203539
• 作为产物：
  描述：

  2,6-dibromobenzamide 在 五氯化磷 、 硫酸 、 sodium nitrite 作用下， 反应 0.17h， 生成 2,6-dibromobenzoyl chloride
  参考文献：
  名称：

  Blackhall, Alexander; Brydon, Donald L.; Javaid, Khalid, Journal of Chemical Research, Miniprint, 1984, # 12, p. 3485 - 3497

  摘要：

  DOI：

文献信息

• Insecticidal 2-phenyl-4-benzoyl-1,2,4-oxadiazolidine-3,5-diones
  申请人：Velsicol Chemical Corporation

  公开号：US03959478A1

  公开（公告）日：1976-05-25

  This invention discloses chemical compounds having the following structural formula ##SPC1## Wherein X is chlorine or fluorine; n is an integer from 1 to 3; and Y is chlorine, bromine or fluorine. The compounds of the above description are useful as insecticides.

  这项发明揭示了具有以下结构式的化合物##SPC1## 其中X是氯或氟；n是1到3之间的整数；Y是氯、溴或氟。上述描述的化合物可用作杀虫剂。
• Noncovalent Interactions in Ir-Catalyzed C–H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters
  作者：Md Emdadul Hoque、Ranjana Bisht、Chabush Haldar、Buddhadeb Chattopadhyay

  DOI：10.1021/jacs.7b04490

  日期：2017.6.14

  An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented

  描述了一种用于芳族酯的对位选择性硼化的有效策略。为了获得高的对位选择性，已经开发了一种新的催化体系，该体系改变了联吡啶的核心结构。有人提出，L型配体对于通过非共价相互作用识别酯羰基的氧原子的功能至关重要，这为超选择性C–H活化/硼化提供了空前的控制因素。
• Synthesis and Biological Evaluation of Analogues of a Novel Inhibitor of β-Amyloid Secretion
  作者：Enakshi Chakrabarti、Subrata Ghosh、Sushabhan Sadhukhan、Lawrence Sayre、Gregory P. Tochtrop、Jonathan D. Smith

  DOI：10.1021/jm100308g

  日期：2010.7.22

  A drug library of 17200 compounds was screened to select small molecules that inhibit the secretion of amyloid beta peptide (Am, the major component of Alzheimer disease senile plaques, from a human neuronal cell line. Twenty-nine hits were validated that decreased A beta secretion by >40% at 10 mu M, for a 0.17% hit rate. A lead hit was selected for further study based on its activity and low cytotoxicity, and it was found to inhibit A beta secretion through activation of the alpha-secretase pathway. Twenty-four commercially available and 53 synthesized analogues were analyzed for activity. Selected analogues were evaluated for biological stability by incubation with hepatoma cells and for transcellular permeability using Caco-2 cell monolayers. The analogue with the best permeability was evaluated in 2-month old amyloid precursor protein transgenic mice and found to acutely reduce cerebral A beta levels by 40% after a single iv administration.
• WO2007/144327
  申请人：——

  公开号：——

  公开（公告）日：——
• Sudborough, Journal of the Chemical Society, 1895, vol. 67, p. 602
  作者：Sudborough

  DOI：——

  日期：——