2-肼基-5-苯基-1,3,4-恶二唑 | 35220-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-肼基-5-苯基-1,3,4-恶二唑
• 英文名称: 2-Hydrazino-5-phenyl-1,3,4-oxadiazole
• 英文别名: 2-Hydrazinyl-5-phenyl-1,3,4-oxadiazole；(5-phenyl-1,3,4-oxadiazol-2-yl)hydrazine
• CAS: 35220-12-3
• 化学式: C₈H₈N₄O
• mdl: MFCD06660926
• 分子量: 176.178
• InChiKey: BUWXFCDANCWLLE-UHFFFAOYSA-N

物化性质

• 沸点：
  287.6±23.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-肼基-5-苯基-1,3,4-恶二唑 在 吡啶 作用下， 反应 23.0h， 生成 diethyl [2-[C-methyl-N-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]carbonimidoyl]phenyl] phosphate
  参考文献：
  名称：

  新型有机磷化合物的合成、结构和真菌毒性

  摘要：

  摘要 通过 O,O-二乙基氯磷酸酯与衍生自 5-(苯基/取代苯基)-2-肼基-1,3,4-恶二唑和水杨醛/2-的席夫碱反应合成了一系列具有生物活性的有机磷化合物。羟基苯乙酮。这些化合物已在分析和光谱（IR、1H、13C NMR）数据的基础上进行了表征。已经评估了这些衍生物对镰状炭疽菌、尖孢镰刀菌和浅色弯孢霉的杀真菌活性。所有化合物均表现出中等至显着的抗真菌活性。图形概要

  DOI：

  10.1080/10426507.2012.681408
• 作为产物：
  描述：

  5-苯基-2-氨基-1,3,4-噁二唑 在 盐酸 、 溶剂黄146 、 锌 、 sodium nitrite 作用下， 反应 2.0h， 生成 2-肼基-5-苯基-1,3,4-恶二唑
  参考文献：
  名称：

  Singh, H.; Srivastava, V.K.; Shukla, S.N., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1994, vol. 33, # 4, p. 350 - 353

  摘要：

  DOI：

文献信息

• A New Route to Synthesis of 3,6-Diaryl-1,2,4-triazolo[3,4-<i>b</i>]1,3,4-oxadiazoles
  作者：Zao-Zao Qiu、Chao-Feng Dai、Shu-Jun Chao、Peng-Fei Xu、Zi-Yi Zhang

  DOI：10.1002/jccs.200400195

  日期：2004.12

  4-triazoles and 1,3,4-oxadiazole derivatives have been reported to possess diverse biological activities.In addition to above biological activity, we coupled these two rings together to get 1,2,4-triazolo[3,4-b] 1,3,4-oxadiazole derivatives. This ring system was first reported in 1961[1] and synthesized in 1971.……

  据报道，各种1,2,4-三唑和1,3,4-恶二唑衍生物具有多种生物活性。除上述生物活性外，我们将这两个环偶联在一起得到1,2,4-三唑[3 ,4-b] 1,3,4-恶二唑衍生物。该环系于1961年首次报道[1]，于1971年合成……
• Sahu, J. K.; Dehuri, S. N.; Naik, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 2, p. 117 - 120
  作者：Sahu, J. K.、Dehuri, S. N.、Naik, S.、Nayak, A.

  DOI：——

  日期：——
• Dehuri, S. N.; Pradhan, P. C.; Nayak, A., Journal of the Indian Chemical Society, 1983, vol. 60, p. 475 - 478
  作者：Dehuri, S. N.、Pradhan, P. C.、Nayak, A.

  DOI：——

  日期：——
• Nizamuddin; Alauddin, Shafqat; Gupta, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 6, p. 1314 - 1318
  作者：Nizamuddin、Alauddin, Shafqat、Gupta、Srivastav, Manoj Kumar

  DOI：——

  日期：——
• Synthesis and spectral characterization of Zn(II) microsphere series for antimicrobial application
  作者：Ajay K. Singh、Sarvesh K. Pandey、O.P. Pandey、S.K. Sengupta

  DOI：10.1016/j.molstruc.2014.06.009

  日期：2014.9

  Microsphere series have been synthesized by reacting zinc(II) acetate dihydrate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole/oxadiazole/triazole with salicylaldehyde. Elemental analysis suggests that the complexes have 1:2 and 1:1 stoichiometry of the type [Zn(L)(2)(H2O)(2)] and [Zn(L')(2)(H2O)(2)]; LH = Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thia/oxadiazole with salicylaldehyde; L'H-2 = Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole and salicylaldehyde and were characterized by elemental analyses, IR, H-1 NMR and C-13 NMR spectral data. Scanning electron microscopy (SEM) showed that synthesized materials have microsphere like structure and there EDX analysis comparably matches with elemental analysis. For the antimicrobial application Schiff bases and their zinc(II) complexes were screened for four bacteria e.g. Bacillus subtilis, Pseudomonas aeruginosa, Salmonella typhi, Streptococcus pyogenes and four fungi e.g. Cyrtomium falcatum, Aspergillus niger, Fusarium oxysporium and Curvularia pallescence by the reported method. Schiff base and Zn(II) compounds showed significant antimicrobial activities. However, activities increase upon chelation. Thermal analysis (TGA) data of compound (10) showed its stability up to 300 degrees C. (C) 2014 Elsevier B.V. All rights reserved.