3-benzyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine | 62717-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 3-benzyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
• 英文别名: 3-benzyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
• CAS: 62717-64-0
• 化学式: C₂₃H₂₃NO₂
• 分子量: 345.441
• InChiKey: JPMFSMDSBJSCSH-UHFFFAOYSA-N

物化性质

• 沸点：
  532.4±50.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-benzyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 生成 7-acetamido-3-benzyl-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  参考文献：
  名称：

  HOLDEN, K. G.;KAISER, C.;WEINSTOCK, J.

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓 、 溴甲苯 生成 3-benzyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  参考文献：
  名称：

  HOLDEN, K. G.;KAISER, C.;WEINSTOCK, J.

  摘要：

  DOI：

文献信息

• 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
  申请人：SmithKline Corporation

  公开号：US04284556A1

  公开（公告）日：1981-08-18

  A group of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have amino, hydroxy substituents at the 7,8-positions of the benzazepine nucleus is disclosed. Novel intermediates and routes of synthesis used for preparing them are also described. The end products have pharmacodynamic activity.

  一组1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶的结构，在苯并哌啶核的7,8-位置具有氨基、羟基取代基。还披露了用于制备它们的新型中间体和合成路线。最终产物具有药效活性。
• Pharmaceutical compositions and method of producing anti-Parkinsonism
  申请人：SmithKline Corporation

  公开号：US04052506A1

  公开（公告）日：1977-10-04

  Pharmaceutical compositions and method of producing anti-Parkinsonism activity by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal.

  药物组合物和通过内服对动物施加一种苯并二氮杂环衍生物的无毒有效量来产生抗帕金森症活性的制备方法。
• Process useful for preparing 7,8-acetamido,
  申请人：SmithKline Beckman Corporation

  公开号：US04382029A1

  公开（公告）日：1983-05-03

  A chemical process is described for preparing 7,8-acetamido, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines which involves reacting a 7,8-quinone derivative of a 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine with a benzyl or benzhydrylamine followed by hydrolysis of the resulting imine and reaction with acetic anhydride or acetyl chloride.

  描述了一种化学过程，用于制备7,8-乙酰胺基，羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶，其中涉及将1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶的7,8-醌衍生物与苄基或苯甲基胺反应，随后水解所得亚胺并与乙酸酐或乙酰氯反应。
• Intermediates for preparing 7,8-amino,
  申请人：SmithKline Corporation

  公开号：US04327023A1

  公开（公告）日：1982-04-27

  A group of new chemical compounds are described which are intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. The intermediates are distinguished in structure by a benzyloxy substituent at either the 7 or 8-position.

  描述了一组新的化合物，它们是制备7,8-氨基，羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶的中间体。这些中间体在结构上以7位或8位的苄氧基取代物为特征。
• 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, process for their preparation and pharmaceutical compositions containing them
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0033632A2

  公开（公告）日：1981-08-12

  A group of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benz- azepines having structures with amino, hydroxy substituents at the 7,8-positions of the benzazepine nucleus is disclosed. Also described are pharmacodynamic pharmaceutical compositions containing them and processes for their preparation.

  本研究公开了一组 1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓，其结构在苯并氮杂卓核的 7、8 位上具有氨基和羟基取代基。还描述了含有它们的药效学药物组合物及其制备工艺。