乙基对甲苯基碳酸酯 | 22719-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 乙基对甲苯基碳酸酯
• 英文名称: Ethyl-(4-methylphenyl)-carbonat
• 英文别名: O-Ethoxycarbonyl-p-kresol；(4-Tolyl)-ethyl-carbonat；Ethyl p-methylphenylcarbonat；4-methylphenyl ethyl carbonate；carbonic acid ethyl ester-p-tolyl ester；Kohlensaeure-aethylester-p-tolylester；Aethyl-p-tolyl-carbonat；ethyl p-tolyl carbonate；ethyl (4-methylphenyl) carbonate
• CAS: 22719-81-9
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: SMZZUTOGLVAUKB-UHFFFAOYSA-N

物化性质

• LogP：
  2.465 (est)
• 保留指数：
  1304

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2920909090

反应信息

• 作为反应物：
  描述：

  乙基对甲苯基碳酸酯 在 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 乙腈 为溶剂， 反应 13.0h， 生成
  参考文献：
  名称：

  Synthesis, Antifungal Activity, and Molecular Docking Studies of Novel Triazole Derivatives

  摘要：

  为了满足对新型抗真菌剂的迫切需求，这些药物具有改善的活性和更广的谱系，设计、合成并评估了一系列3/4-[[N-烷基-2-(2,4-二氟苯)-2-羟基-3-(1H-1,2,4-三唑)]丙胺基]苯乙基碳酸酯作为抗真菌剂。MIC80值表明，所有化合物在几乎所有测试的真菌病原体上仅表现出适度甚至没有抗真菌活性。此外，最具活性的化合物在CACYP51药物结合位点的相互作用也通过对接研究得到了探索。

  DOI：

  10.2174/1573406411309030009
• 作为产物：
  描述：

  p-tolyl methoxyformate 以 氘代乙腈 为溶剂， 反应 40.0h， 生成 乙基对甲苯基碳酸酯
  参考文献：
  名称：

  On the reactivity of imidazole carbamates and ureas and their use as esterification and amidation reagents

  摘要：

  The optimization, substrate scope, and mechanism of esterification and amidation of carboxylic acids mediated by imidazole-based reagents are discussed. The innate reactivity of carbonylimidazole reagents with a range of nucleophiles is also explored. New reagents developed for the synthesis of alpha,beta-unsaturated esters are described, as are reagents for the preparation of tertiary amides directly from carboxylic acids. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.057

文献信息

• Method for Producing Diaryl Carbonate
  申请人：Nishiyama Budianto

  公开号：US20120316357A1

  公开（公告）日：2012-12-13

  The present invention provides a method for continuously producing a diaryl carbonate stably for a long time with high productivity. The method for producing a diaryl carbonate according to the present invention comprises a step (1) of obtaining an alkylaryl carbonate; a step (2) of obtaining a reaction product from the alkylaryl carbonate; a step (3) of separating the diaryl carbonate and a high boiling component from the reaction product; and a step (4) of recycling the high boiling component into the steps (1) and/or (2), wherein the high boiling component recycled in the step (4) includes a particular compound, and the particular compound satisfies a particular condition.

  本发明提供了一种稳定长时间高产量连续生产二芳基碳酸酯的方法。根据本发明的生产二芳基碳酸酯的方法包括以下步骤：（1）获得烷基芳基碳酸酯；（2）从烷基芳基碳酸酯获得反应产物；（3）从反应产物中分离出二芳基碳酸酯和高沸点组分；（4）将高沸点组分回收到步骤（1）和/或（2）中，其中在步骤（4）中回收的高沸点组分包括特定化合物，且该特定化合物符合特定条件。
• Process For The Preparation Of Diaryl Carbonates Or Arylalkyl Carbonates From Dialkyl Carbonates
  申请人：Dux Andre

  公开号：US20080293960A1

  公开（公告）日：2008-11-27

  The invention provides a process for the preparation of diaryl carbonates and/or alkylaryl carbonates from dialkyl carbonates and aromatic hydroxy compounds using one or more intermediate condensers for improving heat integration.

  该发明提供了一种从二烷基碳酸酯和芳香族羟基化合物制备二芳基碳酸酯和/或烷基芳基碳酸酯的过程，使用一个或多个中间冷凝器以改善热集成。
• Novel carbapenem derivatives
  申请人：——

  公开号：US20030149016A1

  公开（公告）日：2003-08-07

  Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the, carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant- Pseudomonas aeruginosa , PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof: 1

  本发明公开了一种新型碳青霉烯衍生物，其在碳青霉烯环上的2位上具有取代咪唑[5,1-b]噻唑基团，对β-内酰胺酶产生的细菌、MRSA、耐药性假单胞菌、PRSP、肠球菌和流感病毒具有高抗菌活性，并对DHP-1具有高稳定性。根据本发明，提供了由式(I)表示的化合物，或其在碳青霉烯环上的3位处的药理学上可接受的盐或酯：1。
• Method for producing an aromatic carbonate
  申请人：Miyake Nobuhisa

  公开号：US20070055042A1

  公开（公告）日：2007-03-08

  A method for producing an aromatic carbonate, comprising: (1) performing a reaction between an organometal compound and carbon dioxide to obtain a reaction mixture containing a dialkyl carbonate formed by the reaction, (2) separating the dialkyl carbonate from the reaction mixture to obtain a residual liquid, (3) reacting the residual liquid with an alcohol to form at least one organometal compound and form water and removing the water from the organometal compound, and (4) reacting the dialkyl carbonate separated in step (2) with an aromatic hydroxy compound to obtain an aromatic carbonate.

  一种生产芳香族碳酸酯的方法，包括：（1）在有机金属化合物和二氧化碳之间进行反应，以获得反应混合物，其中包含通过反应形成的二烷基碳酸酯，（2）从反应混合物中分离出二烷基碳酸酯以获得残留液，（3）将残留液与醇反应，形成至少一种有机金属化合物并形成水，并从有机金属化合物中除去水，（4）将在步骤（2）中分离的二烷基碳酸酯与芳香族羟基化合物反应，以获得芳香族碳酸酯。
• NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND TRIFLUOROMETHYLBENZENE COMPOUND
  申请人：ABE Koji

  公开号：US20140038060A1

  公开（公告）日：2014-02-06

  The present invention is to provide a nonaqueous electrolytic solution capable of enhancing electrochemical characteristics in a broad temperature range, an energy storage device using the nonaqueous electrolytic solution, and a specific trifluoromethylbenzene compound. There are provided a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, which comprises at least one halogenoalkylbenzene compound represented by the following general formula (I), an energy storage device using the nonaqueous electrolytic solution, and a specific trifluoromethylbenzene compound. (In the formula, Y 1 represents an alkoxycarbonyl group having from 2 to 8 carbon atoms, an alkenyloxycarbonyl group having from 3 to 9 carbon atoms, an alkynyloxycarbonyl group having from 4 to 9 carbon atoms, an aryloxycarbonyl group having from 7 to 12 carbon atoms, an alkanesulfonyl group having from 1 to 6 carbon atoms, or an arylsulfonyl group having from 6 to 12 carbon atoms; R X represents a halogenoalkyl group having from 1 to 4 carbon atoms; n indicates an integer of from 1 to 5. However, when Y 1 is an alkoxycarbonyl group having from 2 to 12 carbon atoms or an aryloxycarbonyl group having from 6 to 12 carbon atoms, the number of carbon atom of R X is 1. In the substituent represented by Y 1 , at least one hydrogen atom may be substituted with a halogen atom.)

  本发明旨在提供一种非水电解质溶液，能够增强广泛温度范围内的电化学特性，使用非水电解质溶液的储能装置以及一种特定的三氟甲基苯化合物。提供了一种电解质盐在非水溶剂中溶解的非水电解质溶液，其中包括至少一种由下述通式（I）表示的卤代烷基苯化合物，使用非水电解质溶液的储能装置以及一种特定的三氟甲基苯化合物。（在公式中，Y1表示具有2至8个碳原子的烷氧羰基基团，具有3至9个碳原子的烯烃氧羰基基团，具有4至9个碳原子的炔烃氧羰基基团，具有7至12个碳原子的芳基氧羰基基团，具有1至6个碳原子的烷基磺酰基团或具有6至12个碳原子的芳基磺酰基团；RX表示具有1至4个碳原子的卤代烷基团；n表示1至5的整数。但是，当Y1是具有2至12个碳原子的烷氧羰基基团或具有6至12个碳原子的芳基氧羰基基团时，RX的碳原子数为1。在Y1所表示的取代基中，至少有一个氢原子可以被卤素原子取代。）